Lack of association between FOXO1 polymorphisms and bacteremia.

Jing Yu, Xiong Wang, Yaowu Zhu, Yanjun Lu, Ziyong Sun

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Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 authors at 2 institutions in 1 country.

Jing YuDepartment of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China.

Xiong WangDepartment of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China.

Yaowu ZhuDepartment of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China.

Yanjun LuDepartment of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China.

Ziyong SunDepartment of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China.

Huazhong University of Science and Technology · CNTongji Hospital · CN

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6 · The paper itself

Abstract

unlabelledIncreasing evidence suggests that FOXO1, one critical gene related to the human immune system, probable is closely to the human infection. In the present study we aimed to investigate genetic association of FOXO1 with bacteremia in Han Chinese. 188 patients with bacteremia diagnosed with blood culture and 250 healthy blood donors without signs of infection were studied, two tagging SNPs of FOXO1 (rs9532571, rs3751436) were selected and genotyped using predesigned TaqMan allelic discrimination assays. The results showed that the allele frequency of rs9532571 and rs3751436 in FOXO1 was not associated with an increased risk of bacteremia (P=0.762, OR=1.05, 95% CI 0.77-1.43; P=0.059, OR=1.34, 95% CI 0.99-1.81 respectively), the genotype distribution of these two SNPs was also not significantly different between bacteremia patients and control groups (P=0.9; P=0.16). Haplotypes in this block were not significantly associated with bacteremia risk.

conclusionthe association between FOXO1 genetic polymorphism and bacteremia has not been observed in the study, maybe a larger sample population and more SNPs in the FOXO1 need to reveal the role in bacteremia in the future.

Indexed as

associationBacteremiaFOXO1SNP

Identifiers

PMID26629162

PMCPMC4659050

OpenAlexW2193747845

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.