ArticleInternational journal of clinical and experimental medicine2015
Berberine alleviates preeclampsia possibly by regulating the expression of interleukin-2/interleukin-10 and Bcl-2/Bax.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 18 citations in OpenAlex.
- Article
- Autophagy-related biomarkers in preeclampsia: the underlying mechanism, correlation to the immune microenvironment and drug screening.BMC pregnancy and childbirth · 2024Article
- Involvement of WNT2 in trophoblast cell behavior in preeclampsia development.Cell cycle (Georgetown, Tex.) · 2020Article
- Association between the IL-6, IL-10, and TNFα gene polymorphisms and preterm-birth in Korean women.Genes & genomics · 2020Article
- GNG7 silencing promotes the proliferation and differentiation of placental cytotrophoblasts in preeclampsia rats through activation of the mTOR signaling pathway.International journal of molecular medicine · 2019Article
- The Role of Interleukin-10 in the Pathophysiology of Preeclampsia.Current hypertension reports · 2018Review
- Systems Pharmacology-Based Approach of Connecting Disease Genes in Genome-Wide Association Studies with Traditional Chinese Medicine.International journal of genomics · 2018Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study is to investigate the effect of berberine on the expression of inflammatory factors interleukin (IL)-2 and IL-10, and the expression of apoptosis proteins Bcl-2 and Bax. A total of 70 SD rats were randomly divided into 7 equal groups, including normal non-pregnant group, normal pregnant group, preeclampsia group, preeclampsia + berberine (50, 100, and 200 mg/kg/day) groups, and preeclampsia + nifedipine (20 mg/kg/day) group. Blood pressure was measured before pregnancy, and on day 15 and 21 of pregnancy. Urines before pregnancy and on day 15 and 21 of pregnancy were collected for the determination of urine protein levels. Peripheral blood was collected from all rats on day 21 of pregnancy to measure the levels of blood urea nitrogen and creatinine. On day 21 of pregnancy, the weight of fetuses and placentas, and the number of normal fetuses were determined. Enzyme-linked immunosorbent assay was performed to determine the levels of IL-2 and IL-10 in plasma. Western blotting was used to measure the expression of Bcl-2 and Bax proteins in placenta of rats with preeclampsia. Treatment with berberine for seven days reduced blood pressure, urine proteins levels, and kidney function in rats with preeclampsia. Berberine improved the number of normal fetuses and the weight of fetuses and placentas from rats with preeclampsia. Berberine up-regulated IL-10 and down-regulated IL-2 in the peripheral blood of SD rats with preeclampsia. Berberine up-regulated Bcl-2 and down-regulated Bax in the placenta of SD rats with preeclampsia. Berberine increases the number and weight of normal fetuses in rats with preeclampsia, possibly by regulating the balance of IL-2 and IL-10, and inhibiting apoptosis.
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Identifiers
26629148PMC4659036W2183382522What OpenQuestion holds
Registered trials
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