Evidence map›Paper›PMID 26629134›Full record

ArticleInternational journal of clinical and experimental medicine2015

Genetic polymorphisms of Trim5a are associated with disease progression in acutely and chronically HIV-infected patients.

Xin Sun, Wei Li, Wenzhen Liu, Rui Wang, Qunhui Li, Hao Wu

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Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
–field-weighted citation impact, top 93% of its field
1 · What the graph read from it

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2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Xin SunMinimally Invasive Therapy Center of Liver Cancer, Beijing You'an Hospital, Capital Medical University 8 Xitoutiao Youwai St, Fengtai District, Beijing 100069, P. R. China.
Wei LiMinimally Invasive Therapy Center of Liver Cancer, Beijing You'an Hospital, Capital Medical University 8 Xitoutiao Youwai St, Fengtai District, Beijing 100069, P. R. China.
Wenzhen LiuDepartment of Comprehensive Medicine, Baoding Hospital for Infectious Diseases Baoding, Hebei Province, China.
Rui WangMinimally Invasive Therapy Center of Liver Cancer, Beijing You'an Hospital, Capital Medical University 8 Xitoutiao Youwai St, Fengtai District, Beijing 100069, P. R. China.
Qunhui LiMinimally Invasive Therapy Center of Liver Cancer, Beijing You'an Hospital, Capital Medical University 8 Xitoutiao Youwai St, Fengtai District, Beijing 100069, P. R. China.
Hao WuMinimally Invasive Therapy Center of Liver Cancer, Beijing You'an Hospital, Capital Medical University 8 Xitoutiao Youwai St, Fengtai District, Beijing 100069, P. R. China.
Beijing YouAn Hospital · CNBaoding People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe tripartite interaction motif 5a (Trim5a) plays critical roles in restricting various kinds of retroviruses in different species. It has been shown that Trim5a could inhibit HIV-1 inhibition in vitro.

methodsIn this study, 16 SNPs of Trim5a gene were screened in 236 acutely HIV-infected patients (169 common type (CT) patients and 67 patients with rapid disease progression). In addition, they were screened in 162 chronically HIV-infected patients (147 common type patients and 15 long-term non-progressors (LTNP)). The potential effects of polymorphisms at Trim5a genes on HIV-infection disease progression were analyzed.

resultsAmong all tested SNP sites, 3 SNPs (rs3824949, rs2291841 and rs11038628) were identified to be associated with rapid disease progression in acutely HIV-infected patients. Carriage of rs3824949 allele G, rs2291841 allele C or rs11038628 allele T associated with rapid disease progression. In chronically HIV-infected patients, Patients carrying rs3802981 allele C or rs3802980 allele A had increased opportunity to be LTNP. We also found that greater age was associated with disease deterioration.

conclusionsDifferent genetic polymorphisms of Trim5a may have an impact on the clinical course of both acute and chronic stages of HIV-infection.

Indexed as

disease progressiongenetic polymorphismsHIV-1Trim5a

Identifiers

PMID26629134
PMCPMC4659023
OpenAlexW2185593138

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.