ArticleInternational journal of clinical and experimental medicine2015
Role of serum polyunsaturated fatty acids in the development of colorectal cancer.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Pro-inflammatory fatty acid profile and colorectal cancer risk: A Mendelian randomisation analysis.European journal of cancer (Oxford, England : 1990) · 2017Pooled it
- The effect of FTO gene rs9939609 polymorphism on the association between colorectal cancer and different types of dietary fat intake: a case-control study.Journal of physiological anthropology · 2023Article
- Comprehensive Insight into Colorectal Cancer Metabolites and Lipids for Human Serum: A Proof-of-Concept Study.International journal of molecular sciences · 2023Article
- Reprogrammed Lipid Metabolism and the Lipid-Associated Hallmarks of Colorectal Cancer.Cancers · 2022Review
- Preferential uptake of polyunsaturated fatty acids by colorectal cancer cells.Scientific reports · 2020Article
- Fatty acids distribution and content in oral squamous cell carcinoma tissue and its adjacent microenvironment.PloS one · 2019Article
- Abnormal octadeca-carbon fatty acids distribution in erythrocyte membrane phospholipids of patients with gastrointestinal tumor.Medicine · 2017Observational
- Plasma Lipidomic Signature of Rectal Adenocarcinoma Reveals Potential Biomarkers.Frontiers in oncology · 2017Article
- Relationship of serum polyunsaturated fatty acids with cytokines in colorectal cancer.World journal of gastroenterology · 2016Article
- Polyunsaturated Fatty Acids and Their Derivatives: Therapeutic Value for Inflammatory, Functional Gastrointestinal Disorders, and Colorectal Cancer.Frontiers in pharmacology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We aimed to investigate the role of serum levels of polyunsaturated fatty acid (PUFA) in the development of colorectal cancer (CRC). Serum levels of n-3 and n-6 PUFA in 69 healthy control (Ctrl), 62 benign colorectal polys (CRP) and 100 CRC patients were detected by gas chromatograph. The adjusted odds ratio (OR) by quartiles of n-3 and n-6 PUFA were analyzed. During the process of Ctrl to CRP, total n-3 PUFA (OR=0.159, P<0.001), total n-6 PUFA (OR=0.190, P<0.001), C20:5 n-3 (OR=0.263, P=0.030), C22:6 n-3 (OR=0.125, P<0.001), and C18:2 n-6 (OR=0.299, P=0.025) were inversely associated with CRP risk. The ratio of total n-6 PUFA and total n-3 PUFA (OR=4.667, P=0.002), and the ratio of C20:4 n-6 and (C20:5 n-3+C22:6 n-3) (OR=6.000, P<0.001) were positively associated with CRP risk. During the process of CRP to CRC, total n-3 PUFA (OR=4.059, P=0.007), total n-6 PUFA (OR=8.146, P<0.001), C22:6 n-3 (OR=3.789, P=0.048), and C18:2 n-6 (OR=3.667, P=0.045) were positively associated with CRC risk. The ratio of C20:4 n-6 and (C20:5 n-3+C22:6 n-3) (OR=0.588, P=0.001) was inversely associated with CRC. In conclusion, our results found that the total n-3 PUFA, C22:6 n-3, the total n-6 PUFA, C18:2 n-6, and the ratio of C20:4 n-6 and (C20:5 n-3 +C22:6 n-3) played controversy role in the process of CRP and the process of CRC, and may provide nutritional intervention suggestions for the clinical practice.
Indexed as
Identifiers
26629093PMC4658982W2195568792What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.