Evidence map›Paper›PMID 26629052›Full record

ArticleInternational journal of clinical and experimental medicine2015

Significance of MMP11 and P14(ARF) expressions in clinical outcomes of patients with laryngeal cancer.

Zufei Li, Shuo Ding, Qi Zhong, Guojun Li, Yang Zhang, Xiaohong ChenZhigang Huang

Abstract read

In one paragraph

Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it

0cells of the map it votes in

11citing papers in PubMed

1.2field-weighted citation impact, top 23% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

MMP11 promotes the proliferation and progression of breast cancer through stabilizing Smad2 protein.Oncology reports · 2021
Article
Matrix Metalloproteinase 11 Is a Potential Therapeutic Target in Lung Adenocarcinoma.Molecular therapy oncolytics · 2019
Article
The association between XRCC1 polymorphism and laryngeal cancer susceptibility in different ethnic groups in Xinjiang, China.International journal of clinical and experimental pathology · 2018
Article
Osteoactivin regulates head and neck squamous cell carcinoma invasion by modulating matrix metalloproteases.Journal of cellular physiology · 2018
Article
Clinicopathological significance of p14OncoTargets and therapy · 2017
Article
Biochemical and Biological Attributes of Matrix Metalloproteinases.Progress in molecular biology and translational science · 2017
Review
Identification of Biomarkers Correlated with the TNM Staging and Overall Survival of Patients with Bladder Cancer.Frontiers in physiology · 2017
Article
p14 expression differences in ovarian benign, borderline and malignant epithelial tumors.Journal of ovarian research · 2016
Article
SSTR2 promoter hypermethylation is associated with the risk and progression of laryngeal squamous cell carcinoma in males.Diagnostic pathology · 2016
Article
Association of SNPs in CDKN2A (P14ARF) Tumour Suppressor Gene With Endometrial Cancer in Postmenopausal Women.In vivo (Athens, Greece)
Article
A Novel Inflammation- and Nutrition-Based Prognostic System for Patients with Laryngeal Squamous Cell Carcinoma: Combination of Red Blood Cell Distribution Width and Body Mass Index (COR-BMI).PloS one
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Zufei LiDepartment of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery (Capital Medical University), Ministry of Education Beijing 100730, China ; Department of Otolaryngology Head and Neck Surgery, Aerospace Center Hospital Beijing 100039, China.

Shuo DingDepartment of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery (Capital Medical University), Ministry of Education Beijing 100730, China.

Qi ZhongDepartment of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery (Capital Medical University), Ministry of Education Beijing 100730, China.

Guojun LiDepartment of Head and Neck Surgery and Epidemiology, The University of Texas MD Anderson Cancer Center Houston, TX, USA.

Yang ZhangDepartment of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery (Capital Medical University), Ministry of Education Beijing 100730, China.

Xiaohong ChenZhigang HuangDepartment of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery (Capital Medical University), Ministry of Education Beijing 100730, China.

Capital Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo evaluate the association of MMP11 and P14(ARF) expression in laryngeal squamous cell carcinoma (LSCC) with clinical pathological characteristics and survival.

methodsThe mRNA and protein levels for both genes were determined in 65 LSCC patients. A log-rank test and Cox models were used to compare survival among different groups.

resultsThe mRNA expressions of MMP11 and P14(ARF) were significantly different between LSCC and their corresponding adjacent tissues (All P < 0.001). The expressions of MMP11 and P14(ARF) were correlated with several clinical characteristics (All P < 0.05). Patients with low MMP11 and high P14(ARF) expression had significantly better survival compared with those with high MMP11 and low P14(ARF) expression, respectively (All P < 0.05). The patients with surgery only had significantly better survival than those with chemoradiotherapy (log rank: P = 0.016), particularly in patients with low MMP11 and high P14(ARF) expression (log rank: P = 0.006). Furthermore, multivariable analysis showed that patients with low MMP11 and high P14(ARF) expression alone had a significantly reduced risk of death compared with those with high MMP11 and low P14(ARF) expression. The reduced risk for overall death was pronounced for patients with low and high expression of both genes (HR, 0.2; 95% CI, 0.1-0.5) compared with any other co-expression status of both genes, particularly for patients with surgery only (HR, 0.1; 95% CI, 0.0-0.9).

conclusionThese results suggest that altered expression of MMP11 and P14(ARF) in tumors may individually, or in combination, predict poor prognosis of LSCC, particularly for patients with surgery only.

Indexed as

biomarkerLSCCMMP11P14ARFsurvival

Identifiers

PMID26629052

PMCPMC4658941

OpenAlexW2195739325

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.