ArticleInternational journal of clinical and experimental medicine2015
Curcumin protects against cerebral ischemia-reperfusion injury by activating JAK2/STAT3 signaling pathway in rats.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 56 citations in OpenAlex.
- Targeting JAK/STAT signaling pathway by curcumin: implications for spinal cord injury neuroprotection.Inflammopharmacology · 2025Review
- Targeting PI3K/Akt in Cerebral Ischemia Reperfusion Injury Alleviation: From Signaling Networks to Targeted Therapy.Molecular neurobiology · 2024Review
- Effect of scutellarin on BV-2 microglial-mediated apoptosis in PC12 cells via JAK2/STAT3 signalling pathway.Scientific reports · 2024Article
- Mechanisms of mitophagy and oxidative stress in cerebral ischemia-reperfusion, vascular dementia, and Alzheimer's disease.Frontiers in molecular neuroscience · 2024Review
- Network pharmacology to explore the mechanism of scutellarin in the treatment of brain ischaemia and experimental verification of JAK2/STAT3 signalling pathway.Scientific reports · 2023Article
- Curcumin's mechanism of action against ischemic stroke: A network pharmacology and molecular dynamics study.PloS one · 2023Article
- Role of Endothelial STAT3 in Cerebrovascular Function and Protection from Ischemic Brain Injury.International journal of molecular sciences · 2022Article
- To discuss the mechanism of colchicine in the treatment of acute cerebral infarction based on network pharmacology.Medicine · 2022Article
- Mechanisms Underlying Curcumin-Induced Neuroprotection in Cerebral Ischemia.Frontiers in pharmacology · 2022Review
- Protective Effect of Curcumin on CA1 Region of Hippocampus in Rat Model of Ischemia/ Reperfusion Injury:.Galen medical journal · 2022Article
- COVID-19, cytokines, inflammation, and spices: How are they related?Life sciences · 2021Review
- Icariin enhance mild hypothermia-induced neuroprotection via inhibiting the activation of NF-κB in experimental ischemic stroke.Metabolic brain disease · 2021Article
- Paeoniflorin protects PC12 cells from oxygen-glucose deprivation/reoxygenation-induced injury via activating JAK2/STAT3 signaling.Experimental and therapeutic medicine · 2021Article
- Effects of Medicinal Plants and Flavonoids on Parkinson's Disease: A Review on Basic and Clinical Evidences.Advanced pharmaceutical bulletin · 2021Review
- Neuroprotective Effect for Cerebral Ischemia by Natural Products: A Review.Frontiers in pharmacology · 2021Review
- Curcumin Efficacy in a Serum/Glucose Deprivation-Induced Neuronal PC12 Injury Model.Current molecular pharmacology · 2021Article
- Hexahydrocurcumin alleviated blood-brain barrier dysfunction in cerebral ischemia/reperfusion rats.Pharmacological reports : PR · 2020Article
- The JAK2/STAT3 pathway is involved in dexmedetomidine-induced myocardial protection in rats undergoing cardiopulmonary bypass.Annals of translational medicine · 2020Article
- Chronic Hypoxia-Induced Microvessel Proliferation and Basal Membrane Degradation in the Bone Marrow of Rats Regulated through the IL-6/JAK2/STAT3/MMP-9 Pathway.BioMed research international · 2020Article
- Neuroprotective potency of some spice herbs, a literature review.Journal of traditional and complementary medicine · 2019Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Curcumin (Cur) is the active component in Curcuma longa, and it has been reported to exhibit a variety of biological effects such as anti-inflammation and anti-oxidation. This study aims to investigate the effect of Cur on cerebral ischemia-reperfusion injury and whether the Janus kinase 2 and signal transducer and activator 3 of transcription (JAK2/STAT3) signaling pathway is involved in the neuroprotective effects of Cur. Rats were subjected to 2 h transient middle cerebral artery occlusion (MCAO), followed by 24 h reperfusion. Rats were randomly assigned into sham group, MCAO group, MCAO + Cur group. AG490, a JAK2 inhibitor, was utilized to throw light upon the underlying mechanism. The results suggested that compared to MCAO, Cur attenuated neurological deficits, reduced cerebral infarction area and lowered brain water content. In addition, Cur reduced the activity of IL-1β and IL-8. The results of western blot indicated that Cur enhanced the expression of p-JAK2 and p-STAT3, which was abolished by AG490 administration. Our results suggested that Cur protects effects against cerebral I/R injury through the activation of JAK2/STAT3 signaling pathway.
Indexed as
Identifiers
26628981PMC4658870W2192188554What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.