Evidence map›Paper›PMID 26628906›Full record

ArticleScoliosis2015

Fasting total ghrelin levels are increased in patients with adolescent idiopathic scoliosis.

Jérôme Sales de Gauzy, Isabelle Gennero, Olivier Delrous, Jean-Pierre Salles, Benoit Lepage, Franck Accadbled

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scoliosis, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02829476 (Ghrelin Cellular Resistance Study in Adolescents With Idiopathic Scoliosis), which is not on this map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02829476 nacompletednot on this map

Ghrelin Cellular Resistance Study in Adolescents With Idiopathic Scoliosis

TypeinterventionalSponsorUniversity Hospital, ToulouseRan2010 to 2012Enrolled45ConditionsScoliosisArmsOsteoblast sample
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Genetics and pathogenesis of scoliosis.North American Spine Society journal · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Jérôme Sales de GauzyPediatric Orthopaedics Unit, Children Hospital, CHU de Toulouse, France ; Biomechanics Laboratory, Paul-Sabatier University, Toulouse, France.
Isabelle GenneroINSERM Unit 1043, Physiopathology Center of Toulouse Purpan (CTPT), Paul-Sabatier University, Toulouse, France ; Biochemistry Laboratory, Institut Fédératif de Biologie, University Hospital Center, CHU de Toulouse, France.
Olivier DelrousBiochemistry Laboratory, Institut Fédératif de Biologie, University Hospital Center, CHU de Toulouse, France.
Jean-Pierre SallesINSERM Unit 1043, Physiopathology Center of Toulouse Purpan (CTPT), Paul-Sabatier University, Toulouse, France ; Endocrine and Bone Diseases Unit, Children Hospital, University Hospital Center, CHU de Toulouse, France ; Pediatric Clinical Investigation Center, Children Hospital, University Hospital Center, CHU de Toulouse, France.
Benoit LepageDepartment of Epidemiology, University Hospital Center, Paul-Sabatier University, CHU de Toulouse, France.
Franck AccadbledPediatric Orthopaedics Unit, Children Hospital, CHU de Toulouse, France ; Biomechanics Laboratory, Paul-Sabatier University, Toulouse, France.
Université Toulouse III - Paul Sabatier · FRCentre Hospitalier Universitaire de Toulouse · FRInserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA control study was designed to investigate circulating Ghrelin levels in adolescent girls with adolescent idiopathic scoliosis (AIS) and controls. Eating behavioral disorders, endocrine disorders, abnormal growth pattern and osteopenia have been well documented in AIS. Ghrelin is an orexigenic hormone produced by the stomach which reflects body weight changes and stimulates growth hormone secretion. Recently, it has been shown to be associated with bone metabolism and eating behavior. However, the circulating levels of ghrelin have never been evaluated in AIS patients.

methodsForty nine AIS girls and 15 controls were included. Anthropometric parameters and fasting circulating total ghrelin were measured. Curve severity was evaluated in AIS girls. The relationships between ghrelin and age, body weight, height, body mass index (BMI), BMI Z-score and corrected anthropometric parameters were analyzed in AIS girls and controls.

resultsThere was no significant difference in body weight, height, BMI or BMI Z-score between AIS and controls. Serum ghrelin level was 1.8 fold higher in AIS girls than in controls. Elevation of ghrelin levels remained significant when corrected BMI or corrected BMI Z-score were considered. Unlike in controls, positive correlations were found between ghrelin and age in AIS girls with a gradual increase of circulating ghrelin with age.

conclusionsWe have observed significantly higher circulating ghrelin levels in AIS than in controls with a positive correlation with age. This pilot-study suggests that ghrelin signaling might play a role in the initiation or development of AIS. Further studies are needed to validate theses results.

Indexed as

Adolescent idiopathic scoliosis (AIS)GhrelinGirlHormoneSpine

Identifiers

PMID26628906
PMCPMC4666062
OpenAlexW153107782

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.