ArticleAnnals of general psychiatry2015
The neurocognitive functioning in bipolar disorder: a systematic review of data.
Article in Annals of general psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed.
- Effects of Bipolar Disorder on the Verbal Fluency Skills of Native Speakers.Brain sciences · 2026Article
- Cognitive Impairment and Non-Invasive Neuromodulation Interventions in Bipolar Disorder: A Narrative Review of Current Status and Future Directions.Alpha psychiatry · 2026Review
- Effects of Shared and Nonshared Schizophrenia and Bipolar Disorder Alleles on Cognition and Educational Attainment in the UK Biobank.Biological psychiatry global open science · 2025Article
- Differential relationships among homocysteine levels, cognitive deficits, and low-frequency fluctuation in brain activity in bipolar disorder with suicidal ideation.BMC psychiatry · 2025Article
- The Inaccuracy of the Mood Disorder Questionnaire for Bipolar Disorder in a Community Sample: From the "DYMERS" Construct Toward a New Instrument for Detecting Vulnerable Conditions.Journal of clinical medicine · 2025Article
- Painting psychosis: an empirical investigation of the self-portraits of Edvard Munch.Frontiers in psychiatry · 2025Article
- Memory Function in Euthymic Patients with Bipolar I Disorder: A Cross-Sectional Study of Clinical and Demographic Correlates.Medical journal of the Islamic Republic of Iran · 2025Article
- Challenges in the development of treatment guidelines for bipolar disorder.Frontiers in psychiatry · 2025Article
- A Magnetic Resonance Spectroscopy Study on Polarity Subphenotypes in Bipolar Disorder.Diagnostics (Basel, Switzerland) · 2024Article
- A systematic review of the biomarkers associated with cognition and mood state in bipolar disorder.International journal of bipolar disorders · 2024Article
- Subjective cognitive deficits and its correlates among patients with bipolar disorder: Findings from the bipolar disorder course and outcome study from India (BiD-CoIN study).Indian journal of psychiatry · 2023Article
- Herpes simplex virus 1 infection on grey matter and general intelligence in severe mental illness.Translational psychiatry · 2022Article
- Antioxidative Defense Genes and Brain Structure in Youth Bipolar Disorder.The international journal of neuropsychopharmacology · 2022Article
- Relationship between cognitive flexibility and subsequent course of mood symptoms and suicidal ideation in young adults with childhood-onset bipolar disorder.European child & adolescent psychiatry · 2022Article
- Cognitive Processes and Legal Capacity in Patients With Bipolar Disorder: A Brief Research Report.Frontiers in psychology · 2022Article
- Cognitive attentional syndrome and metacognitive beliefs as potential treatment targets for metacognitive therapy in bipolar disorder.World journal of psychiatry · 2021Review
- The functional impairment of different subtypes and occupational states in euthymic patients with bipolar disorder.BMC psychiatry · 2021Article
- Article
- Performance on the Wechsler Adult Intelligence Scale (WAIS) in Japanese patients with bipolar and major depressive disorders in euthymic and depressed states.Psychiatry and clinical neurosciences · 2021Article
- Effects of tamoxifen and glutamate and glutamine levels in brain regions in repeated sleep deprivation-induced mania model in mice.Naunyn-Schmiedeberg's archives of pharmacology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDuring the last decades, there have been many different opinions concerning the neurocognitive function in Bipolar disorder (BD). The aim of the current study was to perform a systematic review of the literature and to synthesize the data in a comprehensive picture of the neurocognitive dysfunction in BD.
methodsPapers were located with searches in PubMed/MEDLINE, through June 1st 2015. The review followed a modified version of the recommendations of the Preferred Items for Reporting of Systematic Reviews and Meta-Analyses statement.
resultsThe initial search returned 110,403 papers. After the deletion of duplicates, 11,771 papers remained for further evaluation. Eventually, 250 were included in the analysis.
conclusionThe current review supports the presence of a neurocognitive deficit in BD, in almost all neurocognitive domains. This deficit is qualitative similar to that observed in schizophrenia but it is less severe. There are no differences between BD subtypes. Its origin is unclear. It seems it is an enduring component and represents a core primary characteristic of the illness, rather than being secondary to the mood state or medication. This core deficit is confounded (either increased or attenuated) by the disease phase, specific personal characteristics of the patients (age, gender, education, etc.), current symptomatology and its treatment (especially psychotic features) and long-term course and long-term exposure to medication, psychiatric and somatic comorbidity and alcohol and/or substance abuse.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.