Evidence map›Paper›PMID 26628841›Full record

ReviewJournal of clinical and experimental hepatology2015

Animal Models Correlating Immune Cells for the Development of NAFLD/NASH.

Srikanth Iyer, Pramod Kumar Upadhyay, Subeer S Majumdar, Perumal Nagarajan

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of clinical and experimental hepatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. [LRG1 inhibits hepatic macrophage activation by enhancing TGF-β1 signaling to alleviate MAFLD in mice].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2023
    Article
  5. Elucidation of Natural Components ofMolecules (Basel, Switzerland) · 2023
    Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. From NASH to HCC: current concepts and future challenges.Nature reviews. Gastroenterology & hepatology · 2019
    Review
  11. [Interleukin-17-mediated inflammation promotes nonalcoholic fatty liver disease in mice with regulation of M1-type macrophage polarization].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2018
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Srikanth IyerNational Institute of Immunology, New Delhi 110067, India.
Pramod Kumar UpadhyayNational Institute of Immunology, New Delhi 110067, India.
Subeer S MajumdarNational Institute of Immunology, New Delhi 110067, India.
Perumal NagarajanNational Institute of Immunology, New Delhi 110067, India.
National Institute of Immunology · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This review mainly elaborates on the animal models available for understanding the pathogenesis of the second hit of non-alcoholic fatty liver disease (NAFLD) involving immune system. This is known to be a step forward from simple steatosis caused during the first hit, which leads to the stage of inflammation followed by more serious liver conditions like non-alcoholic steatohepatitis (NASH) and cirrhosis. Immune-deficient animal models serve as an important tool for understanding the role of a specific cell type or a cytokine in the progression of NAFLD. These animal models can be used in combination with the already available animal models of NAFLD, including dietary models, as well as genetically modified mouse models. Advancements in molecular biological techniques enabled researchers to produce several new animal models for the study of NAFLD, including knockin, generalized knockout, and tissue-specific knockout mice. Development of NASH/NAFLD in various animal models having compromised immune system is discussed in this review.

Indexed as

APPs, acute-phase proteinsBAFF, B cell activating factorBtk, Bruton's tyrosine kinase geneDAMPs, damage-associated molecular patternsHCC, hepatocellular carcinomaimmune cellsIRFs, Interferon regulatory factorsJNK, c-Jun N-terminal kinaseMCD, methionine choline-deficientmouse modelsNAFLDNAFLD, non-alcoholic fatty liver diseaseNASH, non-alcoholic steatohepatitisNLRs, Nod-like receptorsPAMPs, pathogen-associated molecular patterns

Identifiers

PMID26628841
PMCPMC4632099
OpenAlexW2173613973

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.