Evidence map›Paper›PMID 26628839›Full record

ArticleJournal of clinical and experimental hepatology2015

HBsAg Level as Predictor of Liver Fibrosis in HBeAg Positive Patients With Chronic Hepatitis B Virus Infection.

Sundeep K Goyal, Ashok K Jain, Vinod K Dixit, Suneet K Shukla, Mohan Kumar, Jayant Ghosh, Arttrika Ranjan, Neha Gupta, Manish Tripathi

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In one paragraph

Article in Journal of clinical and experimental hepatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Quantitative Anti-HBc in Liver Pathological States in Patients with Chronic Hepatitis B Virus Infection.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2019
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sundeep K GoyalDepartment of Gastroenterology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India.
Ashok K JainDepartment of Gastroenterology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India.
Vinod K DixitDepartment of Gastroenterology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India.
Suneet K ShuklaDepartment of Gastroenterology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India.
Mohan KumarDepartment of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India.
Jayant GhoshDepartment of Gastroenterology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India.
Arttrika RanjanDepartment of Gastroenterology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India.
Neha GuptaDepartment of Gastroenterology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India.
Manish TripathiDepartment of Gastroenterology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsPreliminary data suggests lower serum hepatitis B surface antigen level is associated with more severe liver fibrosis in HBeAg positive patients. We evaluated the association of HBsAg level with biochemical, virological, and histological features in asymptomatic patients with chronic HBV infection.

methodsHBsAg levels were measured at baseline in 481 asymptomatic, treatment naive patients with chronic HBV infection. Subjects were followed-up prospectively (median, 12; range, 8-36 months). Phases of HBV infection were defined after regular monitoring of HBV-DNA and transaminases. Liver histology was scored using the METAVIR system.

resultsHBeAg positive (n, 126) patients were significantly younger than HBeAg negative (n, 355), median age 26 vs 30 years; P < 0.01. HBV genotype could be determined in 350 patients, 240 (68.57%) had genotype D and 100 (28.57%) had genotype A. HBsAg level had modest correlation with serum HBV DNA(r = 0.6 vs 0.4 in eAg positive & negative respectively). HBeAg + ve patients with fibrosis score ≥ F2 showed significantly lower median serum HBsAg levels and serum HBV DNA levels compared with patients with F0-F1 score (median, range; 4.51, 2.99-6.10 vs 5.06, 4.13-5.89, P < 0.01) and (8.39, 3.85-10.60, P < 0.01) respectively. Significant inverse correlation of HBsAg level was found with liver fibrosis in eAg positive group (r = -0.76; P < 0.001). HBsAg level cut off value 4.7 log10 IU/ml predicted moderate to advance fibrosis (F ≥ 2) with 92% sensitivity, 85% specificity & 91% negative predictive value.

conclusionLower HBsAg level might reflect the status of advanced liver fibrosis in HBeAg positive chronic hepatitis B subjects.

Indexed as

ALT, alanine aminotransferasechronic HBV infectionchronic hepatitis BHBsAg quantificationHBV, hepatitis B virusHCC, hepatocellular carcinomahepatic fibrosisliver fibrosisROC, receiver operating characteristics

Identifiers

PMID26628839
PMCPMC4632094

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.