Evidence map›Paper›PMID 26628746›Full record

ArticlePlant physiology2016

Nitro-Fatty Acids in Plant Signaling: Nitro-Linolenic Acid Induces the Molecular Chaperone Network in Arabidopsis.

Capilla Mata-Pérez, Beatriz Sánchez-Calvo, María N Padilla, Juan C Begara-Morales, Francisco Luque, Manuel Melguizo, Jaime Jiménez-Ruiz, Jesús Fierro-Risco, Antonio Peñas-Sanjuán, Raquel Valderrama and 2 more

Open access · bronzeAbstract read
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In one paragraph

Article in Plant physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
18.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 124 citations in OpenAlex.

  1. Integration of NO and HPlant communications · 2026
    Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. NO and HInternational journal of molecular sciences · 2024
    Review
  9. Roles of Reactive Carbonyl Species (RCS) in Plant Response to Abiotic Stress.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  10. Article
  11. Small Heat Shock Protein (Plants (Basel, Switzerland) · 2023
    Article
  12. Review
  13. Review
  14. Functions of NO and HMethods in molecular biology (Clifton, N.J.) · 2023
    Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Capilla Mata-PérezGroup of Biochemistry and Cell Signaling in Nitric Oxide, Department of Experimental Biology, Center for Advanced Studies in Olive Grove and Olive Oils (C.M.-P., B.S.-C., M.N.P, J.C.B.-M., F.L., J.J.-R., J.F.-R., R.V., J.B.B.) and Department of Inorganic and Organic Chemistry (M.M., A.P.-S.), Faculty of Experimental Sciences, Campus Universitario "Las Lagunillas" s/n, University of Jaén, E-23071, Jaén, Spain; andGroup of Antioxidants, Free Radicals, and Nitric Oxide in Biotechnology, Food, and Agriculture, Department of Biochemistry, Cellular and Molecular Biology of Plants, Estación Experimental del Zaidín, Consejo Superior de Investigaciones Científicas, Granada, Spain (F.J.C.).ORCID http://orcid.org/0000-0002-6609-7242
Beatriz Sánchez-CalvoGroup of Biochemistry and Cell Signaling in Nitric Oxide, Department of Experimental Biology, Center for Advanced Studies in Olive Grove and Olive Oils (C.M.-P., B.S.-C., M.N.P, J.C.B.-M., F.L., J.J.-R., J.F.-R., R.V., J.B.B.) and Department of Inorganic and Organic Chemistry (M.M., A.P.-S.), Faculty of Experimental Sciences, Campus Universitario "Las Lagunillas" s/n, University of Jaén, E-23071, Jaén, Spain; andGroup of Antioxidants, Free Radicals, and Nitric Oxide in Biotechnology, Food, and Agriculture, Department of Biochemistry, Cellular and Molecular Biology of Plants, Estación Experimental del Zaidín, Consejo Superior de Investigaciones Científicas, Granada, Spain (F.J.C.).ORCID http://orcid.org/0000-0002-2210-9547
María N PadillaGroup of Biochemistry and Cell Signaling in Nitric Oxide, Department of Experimental Biology, Center for Advanced Studies in Olive Grove and Olive Oils (C.M.-P., B.S.-C., M.N.P, J.C.B.-M., F.L., J.J.-R., J.F.-R., R.V., J.B.B.) and Department of Inorganic and Organic Chemistry (M.M., A.P.-S.), Faculty of Experimental Sciences, Campus Universitario "Las Lagunillas" s/n, University of Jaén, E-23071, Jaén, Spain; andGroup of Antioxidants, Free Radicals, and Nitric Oxide in Biotechnology, Food, and Agriculture, Department of Biochemistry, Cellular and Molecular Biology of Plants, Estación Experimental del Zaidín, Consejo Superior de Investigaciones Científicas, Granada, Spain (F.J.C.).
Juan C Begara-MoralesGroup of Biochemistry and Cell Signaling in Nitric Oxide, Department of Experimental Biology, Center for Advanced Studies in Olive Grove and Olive Oils (C.M.-P., B.S.-C., M.N.P, J.C.B.-M., F.L., J.J.-R., J.F.-R., R.V., J.B.B.) and Department of Inorganic and Organic Chemistry (M.M., A.P.-S.), Faculty of Experimental Sciences, Campus Universitario "Las Lagunillas" s/n, University of Jaén, E-23071, Jaén, Spain; andGroup of Antioxidants, Free Radicals, and Nitric Oxide in Biotechnology, Food, and Agriculture, Department of Biochemistry, Cellular and Molecular Biology of Plants, Estación Experimental del Zaidín, Consejo Superior de Investigaciones Científicas, Granada, Spain (F.J.C.).
Francisco LuqueGroup of Biochemistry and Cell Signaling in Nitric Oxide, Department of Experimental Biology, Center for Advanced Studies in Olive Grove and Olive Oils (C.M.-P., B.S.-C., M.N.P, J.C.B.-M., F.L., J.J.-R., J.F.-R., R.V., J.B.B.) and Department of Inorganic and Organic Chemistry (M.M., A.P.-S.), Faculty of Experimental Sciences, Campus Universitario "Las Lagunillas" s/n, University of Jaén, E-23071, Jaén, Spain; andGroup of Antioxidants, Free Radicals, and Nitric Oxide in Biotechnology, Food, and Agriculture, Department of Biochemistry, Cellular and Molecular Biology of Plants, Estación Experimental del Zaidín, Consejo Superior de Investigaciones Científicas, Granada, Spain (F.J.C.).
Manuel MelguizoGroup of Biochemistry and Cell Signaling in Nitric Oxide, Department of Experimental Biology, Center for Advanced Studies in Olive Grove and Olive Oils (C.M.-P., B.S.-C., M.N.P, J.C.B.-M., F.L., J.J.-R., J.F.-R., R.V., J.B.B.) and Department of Inorganic and Organic Chemistry (M.M., A.P.-S.), Faculty of Experimental Sciences, Campus Universitario "Las Lagunillas" s/n, University of Jaén, E-23071, Jaén, Spain; andGroup of Antioxidants, Free Radicals, and Nitric Oxide in Biotechnology, Food, and Agriculture, Department of Biochemistry, Cellular and Molecular Biology of Plants, Estación Experimental del Zaidín, Consejo Superior de Investigaciones Científicas, Granada, Spain (F.J.C.).
Jaime Jiménez-RuizGroup of Biochemistry and Cell Signaling in Nitric Oxide, Department of Experimental Biology, Center for Advanced Studies in Olive Grove and Olive Oils (C.M.-P., B.S.-C., M.N.P, J.C.B.-M., F.L., J.J.-R., J.F.-R., R.V., J.B.B.) and Department of Inorganic and Organic Chemistry (M.M., A.P.-S.), Faculty of Experimental Sciences, Campus Universitario "Las Lagunillas" s/n, University of Jaén, E-23071, Jaén, Spain; andGroup of Antioxidants, Free Radicals, and Nitric Oxide in Biotechnology, Food, and Agriculture, Department of Biochemistry, Cellular and Molecular Biology of Plants, Estación Experimental del Zaidín, Consejo Superior de Investigaciones Científicas, Granada, Spain (F.J.C.).ORCID http://orcid.org/0000-0001-5284-8837
Jesús Fierro-RiscoGroup of Biochemistry and Cell Signaling in Nitric Oxide, Department of Experimental Biology, Center for Advanced Studies in Olive Grove and Olive Oils (C.M.-P., B.S.-C., M.N.P, J.C.B.-M., F.L., J.J.-R., J.F.-R., R.V., J.B.B.) and Department of Inorganic and Organic Chemistry (M.M., A.P.-S.), Faculty of Experimental Sciences, Campus Universitario "Las Lagunillas" s/n, University of Jaén, E-23071, Jaén, Spain; andGroup of Antioxidants, Free Radicals, and Nitric Oxide in Biotechnology, Food, and Agriculture, Department of Biochemistry, Cellular and Molecular Biology of Plants, Estación Experimental del Zaidín, Consejo Superior de Investigaciones Científicas, Granada, Spain (F.J.C.).
Antonio Peñas-SanjuánGroup of Biochemistry and Cell Signaling in Nitric Oxide, Department of Experimental Biology, Center for Advanced Studies in Olive Grove and Olive Oils (C.M.-P., B.S.-C., M.N.P, J.C.B.-M., F.L., J.J.-R., J.F.-R., R.V., J.B.B.) and Department of Inorganic and Organic Chemistry (M.M., A.P.-S.), Faculty of Experimental Sciences, Campus Universitario "Las Lagunillas" s/n, University of Jaén, E-23071, Jaén, Spain; andGroup of Antioxidants, Free Radicals, and Nitric Oxide in Biotechnology, Food, and Agriculture, Department of Biochemistry, Cellular and Molecular Biology of Plants, Estación Experimental del Zaidín, Consejo Superior de Investigaciones Científicas, Granada, Spain (F.J.C.).
Raquel ValderramaGroup of Biochemistry and Cell Signaling in Nitric Oxide, Department of Experimental Biology, Center for Advanced Studies in Olive Grove and Olive Oils (C.M.-P., B.S.-C., M.N.P, J.C.B.-M., F.L., J.J.-R., J.F.-R., R.V., J.B.B.) and Department of Inorganic and Organic Chemistry (M.M., A.P.-S.), Faculty of Experimental Sciences, Campus Universitario "Las Lagunillas" s/n, University of Jaén, E-23071, Jaén, Spain; andGroup of Antioxidants, Free Radicals, and Nitric Oxide in Biotechnology, Food, and Agriculture, Department of Biochemistry, Cellular and Molecular Biology of Plants, Estación Experimental del Zaidín, Consejo Superior de Investigaciones Científicas, Granada, Spain (F.J.C.).
Francisco J CorpasGroup of Biochemistry and Cell Signaling in Nitric Oxide, Department of Experimental Biology, Center for Advanced Studies in Olive Grove and Olive Oils (C.M.-P., B.S.-C., M.N.P, J.C.B.-M., F.L., J.J.-R., J.F.-R., R.V., J.B.B.) and Department of Inorganic and Organic Chemistry (M.M., A.P.-S.), Faculty of Experimental Sciences, Campus Universitario "Las Lagunillas" s/n, University of Jaén, E-23071, Jaén, Spain; andGroup of Antioxidants, Free Radicals, and Nitric Oxide in Biotechnology, Food, and Agriculture, Department of Biochemistry, Cellular and Molecular Biology of Plants, Estación Experimental del Zaidín, Consejo Superior de Investigaciones Científicas, Granada, Spain (F.J.C.).ORCID http://orcid.org/0000-0002-1814-9212
Juan B BarrosoGroup of Biochemistry and Cell Signaling in Nitric Oxide, Department of Experimental Biology, Center for Advanced Studies in Olive Grove and Olive Oils (C.M.-P., B.S.-C., M.N.P, J.C.B.-M., F.L., J.J.-R., J.F.-R., R.V., J.B.B.) and Department of Inorganic and Organic Chemistry (M.M., A.P.-S.), Faculty of Experimental Sciences, Campus Universitario "Las Lagunillas" s/n, University of Jaén, E-23071, Jaén, Spain; andGroup of Antioxidants, Free Radicals, and Nitric Oxide in Biotechnology, Food, and Agriculture, Department of Biochemistry, Cellular and Molecular Biology of Plants, Estación Experimental del Zaidín, Consejo Superior de Investigaciones Científicas, Granada, Spain (F.J.C.) jbarroso@ujaen.es.ORCID http://orcid.org/0000-0002-9477-9195
Universidad de Jaén · ESConsejo Superior de Investigaciones Científicas · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nitro-fatty acids (NO2-FAs) are the product of the reaction between reactive nitrogen species derived of nitric oxide (NO) and unsaturated fatty acids. In animal systems, NO2-FAs are considered novel signaling mediators of cell function based on a proven antiinflammatory response. Nevertheless, the interaction of NO with fatty acids in plant systems has scarcely been studied. Here, we examine the endogenous occurrence of nitro-linolenic acid (NO2-Ln) in Arabidopsis and the modulation of NO2-Ln levels throughout this plant's development by mass spectrometry. The observed levels of this NO2-FA at picomolar concentrations suggested its role as a signaling effector of cell function. In fact, a transcriptomic analysis by RNA-seq technology established a clear signaling role for this molecule, demonstrating that NO2-Ln was involved in plant defense response against different abiotic-stress conditions, mainly by inducing heat shock proteins and supporting a conserved mechanism of action in both animal and plant defense processes. Bioinformatics analysis revealed that NO2-Ln was also involved in the response to oxidative stress conditions, mainly depicted by H2O2, reactive oxygen species, and oxygen-containing compound responses, with a high induction of ascorbate peroxidase expression. Closely related to these results, NO2-Ln levels significantly rose under several abiotic-stress conditions such as wounding or exposure to salinity, cadmium, and low temperature, thus validating the outcomes found by RNA-seq technology. Jointly, to our knowledge, these are the first results showing the endogenous presence of NO2-Ln in Arabidopsis (Arabidopsis thaliana) and supporting the strong signaling role of these molecules in the defense mechanism against different abiotic-stress situations.

Indexed as

Signal Transductionalpha-Linolenic AcidArabidopsisArabidopsis ProteinsAscorbate PeroxidasesFatty AcidsFatty Acids, UnsaturatedHeat-Shock ProteinsHydrogen PeroxideMolecular ChaperonesNitric OxideOxidation-ReductionReactive Oxygen SpeciesStress, Physiologicalalpha-Linolenic AcidArabidopsis ProteinsAscorbate PeroxidasesFatty AcidsFatty Acids, UnsaturatedHeat-Shock ProteinsHydrogen PeroxideMolecular ChaperonesNitric OxideReactive Oxygen Species

Identifiers

PMID26628746
PMCPMC4734579
OpenAlexW2183834710

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.