Evidence map›Paper›PMID 26628673›Full record

ArticleHypertension (Dallas, Tex. : 1979)2016

Circulating Adipokines and Vascular Function: Cross-Sectional Associations in a Community-Based Cohort.

Justin P Zachariah, Susan Hwang, Naomi M Hamburg, Emelia J Benjamin, Martin G Larson, Daniel Levy, Joseph A Vita, Lisa M Sullivan, Gary F Mitchell, Ramachandran S Vasan

Open access · bronzeAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.

  1. Relationship between circulating leptin levels and arterial stiffness: a systematic review and meta-analysis of observational studies.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2020
    Pooled it
  2. Article
  3. Article
  4. Overweight-Related Hypertension in Middle-Aged Men Is Linked to Elevated Leptin, TNF-α, IL-6, Cholesterol, and Reduced Testosterone.Pathophysiology : the official journal of the International Society for Pathophysiology · 2025
    Article
  5. Leptin bioavailability and markers of brain atrophy and vascular injury in the middle age.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  6. Article
  7. Article
  8. Observational
  9. Review
  10. Review
  11. Adipokines and Arterial Stiffness in Obesity.Medicina (Kaunas, Lithuania) · 2021
    Review
  12. Article
  13. Biological Pathways in Adolescent Aortic Stiffness.Journal of the American Heart Association · 2021
    Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. 70-year legacy of the Framingham Heart Study.Nature reviews. Cardiology · 2019
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Justin P ZachariahFrom the Department of Cardiology, Boston Children's Hospital and Department of Pediatrics Harvard Medical School, MA (J.P.Z.); Department of Biostatistics (S.H., L.M.S.) and Department of Epidemiology (E.J.B., R.S.V.), Boston University School of Public Health, MA; Section of Cardiovascular Medicine, Department of Medicine, Boston University School of Medicine, MA (N.M.H., E.J.B., J.A.V., R.S.V.); Boston University's and National Heart, Blood and Lung Institute's Framingham Heart Study, Framingham, MA (E.J.B., M.G.L., D.L., J.A.V., R.S.V.); Department of Mathematics, Boston University, MA (M.G.L.); and Cardiovascular Engineering, Inc, Norwood, MA (G.F.M.). justinzachariah@yahoo.com.
Susan HwangFrom the Department of Cardiology, Boston Children's Hospital and Department of Pediatrics Harvard Medical School, MA (J.P.Z.); Department of Biostatistics (S.H., L.M.S.) and Department of Epidemiology (E.J.B., R.S.V.), Boston University School of Public Health, MA; Section of Cardiovascular Medicine, Department of Medicine, Boston University School of Medicine, MA (N.M.H., E.J.B., J.A.V., R.S.V.); Boston University's and National Heart, Blood and Lung Institute's Framingham Heart Study, Framingham, MA (E.J.B., M.G.L., D.L., J.A.V., R.S.V.); Department of Mathematics, Boston University, MA (M.G.L.); and Cardiovascular Engineering, Inc, Norwood, MA (G.F.M.).
Naomi M HamburgFrom the Department of Cardiology, Boston Children's Hospital and Department of Pediatrics Harvard Medical School, MA (J.P.Z.); Department of Biostatistics (S.H., L.M.S.) and Department of Epidemiology (E.J.B., R.S.V.), Boston University School of Public Health, MA; Section of Cardiovascular Medicine, Department of Medicine, Boston University School of Medicine, MA (N.M.H., E.J.B., J.A.V., R.S.V.); Boston University's and National Heart, Blood and Lung Institute's Framingham Heart Study, Framingham, MA (E.J.B., M.G.L., D.L., J.A.V., R.S.V.); Department of Mathematics, Boston University, MA (M.G.L.); and Cardiovascular Engineering, Inc, Norwood, MA (G.F.M.).
Emelia J BenjaminFrom the Department of Cardiology, Boston Children's Hospital and Department of Pediatrics Harvard Medical School, MA (J.P.Z.); Department of Biostatistics (S.H., L.M.S.) and Department of Epidemiology (E.J.B., R.S.V.), Boston University School of Public Health, MA; Section of Cardiovascular Medicine, Department of Medicine, Boston University School of Medicine, MA (N.M.H., E.J.B., J.A.V., R.S.V.); Boston University's and National Heart, Blood and Lung Institute's Framingham Heart Study, Framingham, MA (E.J.B., M.G.L., D.L., J.A.V., R.S.V.); Department of Mathematics, Boston University, MA (M.G.L.); and Cardiovascular Engineering, Inc, Norwood, MA (G.F.M.).
Martin G LarsonFrom the Department of Cardiology, Boston Children's Hospital and Department of Pediatrics Harvard Medical School, MA (J.P.Z.); Department of Biostatistics (S.H., L.M.S.) and Department of Epidemiology (E.J.B., R.S.V.), Boston University School of Public Health, MA; Section of Cardiovascular Medicine, Department of Medicine, Boston University School of Medicine, MA (N.M.H., E.J.B., J.A.V., R.S.V.); Boston University's and National Heart, Blood and Lung Institute's Framingham Heart Study, Framingham, MA (E.J.B., M.G.L., D.L., J.A.V., R.S.V.); Department of Mathematics, Boston University, MA (M.G.L.); and Cardiovascular Engineering, Inc, Norwood, MA (G.F.M.).
Daniel LevyFrom the Department of Cardiology, Boston Children's Hospital and Department of Pediatrics Harvard Medical School, MA (J.P.Z.); Department of Biostatistics (S.H., L.M.S.) and Department of Epidemiology (E.J.B., R.S.V.), Boston University School of Public Health, MA; Section of Cardiovascular Medicine, Department of Medicine, Boston University School of Medicine, MA (N.M.H., E.J.B., J.A.V., R.S.V.); Boston University's and National Heart, Blood and Lung Institute's Framingham Heart Study, Framingham, MA (E.J.B., M.G.L., D.L., J.A.V., R.S.V.); Department of Mathematics, Boston University, MA (M.G.L.); and Cardiovascular Engineering, Inc, Norwood, MA (G.F.M.).
Joseph A VitaFrom the Department of Cardiology, Boston Children's Hospital and Department of Pediatrics Harvard Medical School, MA (J.P.Z.); Department of Biostatistics (S.H., L.M.S.) and Department of Epidemiology (E.J.B., R.S.V.), Boston University School of Public Health, MA; Section of Cardiovascular Medicine, Department of Medicine, Boston University School of Medicine, MA (N.M.H., E.J.B., J.A.V., R.S.V.); Boston University's and National Heart, Blood and Lung Institute's Framingham Heart Study, Framingham, MA (E.J.B., M.G.L., D.L., J.A.V., R.S.V.); Department of Mathematics, Boston University, MA (M.G.L.); and Cardiovascular Engineering, Inc, Norwood, MA (G.F.M.).
Lisa M SullivanFrom the Department of Cardiology, Boston Children's Hospital and Department of Pediatrics Harvard Medical School, MA (J.P.Z.); Department of Biostatistics (S.H., L.M.S.) and Department of Epidemiology (E.J.B., R.S.V.), Boston University School of Public Health, MA; Section of Cardiovascular Medicine, Department of Medicine, Boston University School of Medicine, MA (N.M.H., E.J.B., J.A.V., R.S.V.); Boston University's and National Heart, Blood and Lung Institute's Framingham Heart Study, Framingham, MA (E.J.B., M.G.L., D.L., J.A.V., R.S.V.); Department of Mathematics, Boston University, MA (M.G.L.); and Cardiovascular Engineering, Inc, Norwood, MA (G.F.M.).
Gary F MitchellFrom the Department of Cardiology, Boston Children's Hospital and Department of Pediatrics Harvard Medical School, MA (J.P.Z.); Department of Biostatistics (S.H., L.M.S.) and Department of Epidemiology (E.J.B., R.S.V.), Boston University School of Public Health, MA; Section of Cardiovascular Medicine, Department of Medicine, Boston University School of Medicine, MA (N.M.H., E.J.B., J.A.V., R.S.V.); Boston University's and National Heart, Blood and Lung Institute's Framingham Heart Study, Framingham, MA (E.J.B., M.G.L., D.L., J.A.V., R.S.V.); Department of Mathematics, Boston University, MA (M.G.L.); and Cardiovascular Engineering, Inc, Norwood, MA (G.F.M.).
Ramachandran S VasanFrom the Department of Cardiology, Boston Children's Hospital and Department of Pediatrics Harvard Medical School, MA (J.P.Z.); Department of Biostatistics (S.H., L.M.S.) and Department of Epidemiology (E.J.B., R.S.V.), Boston University School of Public Health, MA; Section of Cardiovascular Medicine, Department of Medicine, Boston University School of Medicine, MA (N.M.H., E.J.B., J.A.V., R.S.V.); Boston University's and National Heart, Blood and Lung Institute's Framingham Heart Study, Framingham, MA (E.J.B., M.G.L., D.L., J.A.V., R.S.V.); Department of Mathematics, Boston University, MA (M.G.L.); and Cardiovascular Engineering, Inc, Norwood, MA (G.F.M.).
Boston University · USHarvard University · USNorwood Hospital · USBoston Children's Hospital · US

Funding

Framingham Project/LevyZIAHL006001 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEVY, DANIEL · 2009 to 2025
$51.1M
Clinical and Genetic Correlates of Vascular Function in African Americans: JHSR01HL104184 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI FOX, ERVIN R · 2011 to 2017
$4.5M
Vascular Stiffness as a Precursor of Hypertension in a Middle-aged CohortR01HL126136 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MITCHELL, GARY FRANK, RAMACHANDRAN, VASAN S · 2015 to 2018
$2.6M
Aortic Dysfunction, Pulsatile Stress and Target Organ Damage in FraminghamR01HL107385 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MITCHELL, GARY FRANK, RAMACHANDRAN, VASAN S · 2011 to 2014
$2.6M
AORTA, BRAIN AND KIDNEY STRUCTURE AND FUNCTION IN THE AGES-REYKJAVIK STUDYR01HL094898 · NHLBI · CARDIOVASCULAR ENGINEERING, INC. · PI MITCHELL, GARY FRANK · 2009 to 2012
$2.5M
Kidney Function, Aortic Stiffness and AgingR01DK082447 · NIDDK · TUFTS MEDICAL CENTER · PI LEVEY, ANDREW S · 2010 to 2014
$2.4M
Vascular Function in the Framingham Third GenerationR01HL070100 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BENJAMIN, EMELIA J. · 2002 to 2005
$2.4M
Biomarkers of Metabolic and Vascular Risk in ObesityR01DK080739 · NIDDK · BOSTON UNIVERSITY MEDICAL CAMPUS · PI RAMACHANDRAN, VASAN S · 2008 to 2011
$2.1M
Vascular Remodeling in Overweight and Obese AdolescentsK23HL111335 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI ZACHARIAH, JUSTIN P.V. · 2012 to 2017
$708k
THE FRAMINGHAM HEART STUDY-N01HC25195-268025195-268025195N01HC025195 · HC · TRUSTEES OF BOSTON UNIVERSITY · PI WOLF, PHILIP A · 2002 to 2006
–
NHLBI NIH HHS 1R01-HL-70100NHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS HHSN268201500001INHLBI NIH HHS HL111335NHLBI NIH HHS K23 HL111335NHLBI NIH HHS N01 HC025195NHLBI NIH HHS N01-HC-25195NHLBI NIH HHS R01 HL070100NHLBI NIH HHS R01 HL094898NHLBI NIH HHS R01 HL104184NHLBI NIH HHS R01 HL107385NHLBI NIH HHS R01-HL-107385NHLBI NIH HHS R01 HL126136NHLBI NIH HHS R01-HL-126136NIDDK NIH HHS R01 DK080739NIDDK NIH HHS R01-DK-080739NIDDK NIH HHS R01 DK082447
6 · The paper itself

Abstract

Adipokines may be potential mediators of the association between excess adiposity and vascular dysfunction. We assessed the cross-sectional associations of circulating adipokines with vascular stiffness in a community-based cohort of younger adults. We related circulating concentrations of leptin and leptin receptor, adiponectin, retinol-binding protein 4, and fatty acid-binding protein 4 to vascular stiffness measured by arterial tonometry in 3505 Framingham Third Generation cohort participants free of cardiovascular disease (mean age 40 years, 53% women). Separate regression models estimated the relations of each adipokine to mean arterial pressure and aortic stiffness, as carotid femoral pulse wave velocity, adjusting for age, sex, smoking, heart rate, height, antihypertensive treatment, total and high-density lipoprotein cholesterol, diabetes mellitus, alcohol consumption, estimated glomerular filtration rate, glucose, and C-reactive protein. Models evaluating aortic stiffness also were adjusted for mean arterial pressure. Mean arterial pressure was positively associated with blood retinol-binding protein 4, fatty acid-binding protein 4, and leptin concentrations (all P<0.001) and inversely with adiponectin (P=0.002). In fully adjusted models, mean arterial pressure was positively associated with retinol-binding protein 4 and leptin receptor levels (P<0.002 both). In fully adjusted models, aortic stiffness was positively associated with fatty acid-binding protein 4 concentrations (P=0.02), but inversely with leptin and leptin receptor levels (P≤0.03 both). In our large community-based sample, circulating concentrations of select adipokines were associated with vascular stiffness measures, consistent with the hypothesis that adipokines may influence vascular function and may contribute to the relation between obesity and hypertension.

Indexed as

AdipokinesAdultAgedBlood PressureCross-Sectional StudiesFemaleFollow-Up StudiesHumansHypertensionIncidenceMaleMiddle AgedPulse Wave AnalysisRetrospective StudiesRisk FactorsUnited StatesAdipokinesadipokinesbiomarkersepidemiologyobesityvascular function

Identifiers

PMID26628673
PMCPMC4845672
OpenAlexW2183733460

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.