Evidence map›Paper›PMID 26628616›Full record

Trial reportEuropean heart journal. Cardiovascular Imaging2016

Diastolic function improvement is associated with favourable outcomes in patients with acute non-ischaemic cardiomyopathy: insights from the multicentre IMAC-2 trial.

João L Cavalcante, Josef Marek, Richard Sheppard, Randall C Starling, Paul J Mather, Jeffrey D Alexis, Jagat Narula, Dennis M McNamara, John Gorcsan

Open access · bronzeAbstract readClinical TrialComparative StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European heart journal. Cardiovascular Imaging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Observational
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 8 institutions in 2 countries.

João L CavalcanteHeart & Vascular Institute-UPMC, UPMC/University of Pittsburgh, 200 Lothrop Street, Scaife Hall, S-558, Pittsburgh, PA, USA cavalcantejl@upmc.edu.
Josef MarekHeart & Vascular Institute-UPMC, UPMC/University of Pittsburgh, 200 Lothrop Street, Scaife Hall, S-558, Pittsburgh, PA, USA.
Richard SheppardJewish General Hospital/McGill University, Montreal, Canada.
Randall C StarlingCleveland Clinic Foundation, Cleveland, OH, USA.
Paul J MatherJefferson Medical College of Thomas Jefferson University, Philadelphia, PA, USA.
Jeffrey D AlexisUniversity of Rochester Medical Center, Rochester, NY, USA.
Jagat NarulaMount Sinai Hospital, New York, NY, USA.
Dennis M McNamaraHeart & Vascular Institute-UPMC, UPMC/University of Pittsburgh, 200 Lothrop Street, Scaife Hall, S-558, Pittsburgh, PA, USA.
John GorcsanHeart & Vascular Institute-UPMC, UPMC/University of Pittsburgh, 200 Lothrop Street, Scaife Hall, S-558, Pittsburgh, PA, USA.
UPMC Health System · USCleveland Clinic · USMcGill University · CAMount Sinai Hospital · USThomas Jefferson University · USUniversity of Pittsburgh · USUniversity of Pittsburgh Medical Center · USUniversity of Rochester Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsPatients with recent onset non-ischaemic cardiomyopathy have a variable clinical course with respect to recovery of left ventricular ejection fraction (LVEF). The aim of this study was to understand whether temporal changes in diastolic function (DF) are associated with clinical outcomes independent of LVEF recovery. METHODS AND

resultsThe Intervention in Myocarditis and Acute Cardiomyopathy (IMAC)-2 study was a prospective, multicentre trial investigating myocardial recovery in subjects with symptoms onset of <6 months and LVEF ≤40% of non-ischaemic dilated cardiomyopathy related to idiopathic cardiomyopathy or myocarditis. LVEF and DF were measured at presentation and at 6-month follow-up. Of 147 patients (mean age 46 ± 14 years, 40% female), baseline LVEF was 23 ± 8%. At 6 months, LVEF improved to 41 ± 12%, with 71% increasing by at least 10% ejection fraction units. DF improved in 58%, was unchanged in 28%, and worsened in 14%. Over a mean follow-up of 1.8 ± 1.2 years, there were 18 events: 11 heart failure (HF) hospitalizations, 3 deaths, and 4 heart transplants. LVEF (HR = 0.94, 95% CI 0.91-0.98, P = 0.002) and DF improvements at 6 months (HR = 0.32, 95% CI 0.11-0.92, P = 0.03) were independently associated with lower likelihood for the combined end point of death, transplantation, and HF hospitalization. Diastolic functional improvement at 6-month follow-up was as prognostically important as LVEF recovery for these patients, and provided incremental prognostic value to the risk stratification (X(2) increased from 12.6 to 18, P = 0.02).

conclusionIn patients with recent onset non-ischaemic cardiomyopathy, DF recovery was associated with favourable outcomes independent of LVEF improvement, adding incremental prognostic value to these patients.

Indexed as

EchocardiographyAcute DiseaseAdultCardiomyopathy, DilatedDiastoleFemaleHumansMaleMiddle AgedPrognosisProportional Hazards ModelsProspective StudiesStroke VolumeTime FactorsVentricular Remodelingdiastolic function changesoutcomes assessmentrecent non-ischaemic cardiomyopathy

Identifiers

PMID26628616
PMCPMC5066337
OpenAlexW2186661629

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.