Evidence map›Paper›PMID 26628508›Full record

Trial reportGut2016

Structural robustness of the gut mucosal microbiota is associated with Crohn's disease remission after surgery.

S Mondot, P Lepage, P Seksik, M Allez, X Tréton, Y Bouhnik, J F Colombel, M Leclerc, P Pochart, J Doré and 2 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Gut, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

92 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Trial
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  9. Effect ofWorld journal of gastroenterology · 2017
    Trial
  10. Review
  11. Article
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  18. Gut microbes · 2025
    Article
  19. Article
  20. Review

32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

S MondotINRA, Micalis UMR1319, Jouy-en-Josas, France AgroParisTech, Micalis UMR1319, Jouy-en-Josas, France Institut Curie, U932, Paris, France.
P LepageINRA, Micalis UMR1319, Jouy-en-Josas, France AgroParisTech, Micalis UMR1319, Jouy-en-Josas, France.
P SeksikSorbonne Universités-UPMC Univ Paris 06, INSERM ERL 1157, AP-HP, Hôpital Saint Antoine, CNRS UMR 7203 LBM, CHU Saint-Antoine, Paris, France.
M AllezGastroenterology Department, Hôpital Saint Louis, APHP, INSERM U1160, Université Paris 7, GETAID, Paris, France.
X TrétonGastroenterology Department, Hôpital Beaujon, Clichy, Université Paris 7, GETAID, Paris, France.
Y BouhnikGastroenterology Department, Hôpital Beaujon, Clichy, Université Paris 7, GETAID, Paris, France.
J F ColombelDepartment of Gastroenterology, Icahn School of Medicine, New York, New York, USA.
M LeclercINRA, Micalis UMR1319, Jouy-en-Josas, France AgroParisTech, Micalis UMR1319, Jouy-en-Josas, France.
P PochartEA Laboratoire de Biologie, Conservatoire national des arts et métiers, Paris, France EA4065 Université Paris V, Paris, France.
J DoréINRA, Micalis UMR1319, Jouy-en-Josas, France AgroParisTech, Micalis UMR1319, Jouy-en-Josas, France.
P MarteauGastroenterology Department, Hôpital Lariboisière & Université Denis Diderot-Paris 7, Sorbonne Paris Cité & GETAID, Paris, France.
GETAID

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesPreventing postoperative recurrence after ileocolonic resection (ICR) for Crohn's disease (CD) is challenging. Defining the disturbances of the microbial composition and community structure after ICR and their link with early disease recurrence is crucial.

designMicrobiota composition (fingerprinting and 16S rDNA sequencing) and community structure (correlation networks of bacterial species) were assessed from ileal mucosa sampled in 20 patients undergoing ICR and 6 months later during endoscopy from above (neoterminal ileum) and below (subanastomotic colon) the surgical anastomosis.

resultsICR had a dramatic effect on gut microbial ecosystem. At surgery, CD mucosa harboured a dysbiotic microbiota with high proportions of α/β Proteobacteria and Bacilli. Six months later, half of the patients had recurrent lesions at ileocolonoscopy and presented higher numbers of Lachnospiraceae. Recurrence of endoscopic lesions was associated with enrichment in Enterococcus durans while patients in remission had increased proportions of Dorea longicatena and Bacteroides plebeius. Structural differences were striking between recurrence and remission microbiota; while the microbiota of patients with CD recurrence exhibited a loose community structure, the microbiota of patients in remission displayed communities that were robustly correlated to each other. Microbiota colonising the neoterminal ileum and subanastomotic colon 6 months after ICR only differed in patients with recurrence.

conclusionsICR modifies the gut microbiome. Remission after 6 months was associated with homogenous bacterial distribution around the anastomosis. Community structure and bacterial networks highlight target species, including Faecalibacterium prausnitzii and Ruminococcus gnavus, which may allow precise modulations of the overall microbial ecosystem towards remission pattern.

Indexed as

Gastrointestinal MicrobiomeBiopsyColonCrohn DiseaseDouble-Blind MethodDysbiosisFollow-Up StudiesHumansIleumIntestinal MucosaLactobacillus johnsoniiRecurrenceRemission InductionBACTERIAL INTERACTIONSINFLAMMATORY BOWEL DISEASEINTESTINAL MICROBIOLOGYMOLECULAR BIOLOGYSURGICAL RESECTION

Identifiers

PMID26628508
PMCPMC4893116

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.