Trial reportDiabetes care2016
Pregnancy Outcomes in Youth With Type 2 Diabetes: The TODAY Study Experience.
Trial report in Diabetes care, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT00081328. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Studies to Treat Or Prevent Pediatric Type 2 Diabetes (STOPP-T2D) Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) Clinical Trial
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- Preexisting Diabetes and Pregnancy: An Endocrine Society and European Society of Endocrinology Joint Clinical Practice Guideline.The Journal of clinical endocrinology and metabolism · 2025Guideline
- Early-Onset Type 2 Diabetes and Tirzepatide Treatment: A Post Hoc Analysis From the SURPASS Clinical Trial Program.Diabetes care · 2024Trial
- Effect of type 2 diabetes mellitus on placental expression and activity of nutrient transporters and their association with birth weight and neonatal adiposity.Molecular and cellular endocrinology · 2021Trial
- Extinguishing the Fire: Treating Pediatric Type 2 Diabetes by Targeting Obesity Treatment.Diabetes care · 2025Review
- Risk factors and adverse pregnancy outcomes associated with large for gestational age infants in pregnant women with type 2 diabetes mellitus.BMC pregnancy and childbirth · 2025Article
- Youth-Onset Type 2 Diabetes: What We've Learned From Key Youth-Onset Type 2 Diabetes Studies, What We Still Don't Know, and Why It Is Important.Diabetes care · 2025Review
- Predictors of Composite Maternal and Fetal Outcomes among Pregnant Women with Early-Onset Type 2 Diabetes: A Cross-Sectional Study.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2025Article
- Youth With Type 2 Diabetes Have Low Rates of Contraception and Preconception Counseling Documentation Compared With Adults With Diabetes.Clinical diabetes : a publication of the American Diabetes Association · 2025Article
- Age-related variations in HbA1c improvements: insights from a telehealth-supported community-based intervention.Innovation in aging · 2025Article
- Early onset type 2 diabetes mellitus: an update.Endocrine · 2024Review
- Youth-onset Type 2 Diabetes: An Overview of Pathophysiology, Prognosis, Prevention and Management.Current diabetes reports · 2024Review
- Family planning behaviours among women with diabetes mellitus: a scoping review.European journal of medical research · 2024Article
- Gestational weight gain and pregnancy outcomes in Chinese women with type 2 diabetes mellitus: evidence from a tertiary hospital in Beijing.Frontiers in endocrinology · 2024Article
- Prevalence and risk factors of gestational diabetes in the health region of Lleida: a retrospective observational cohort study.Journal of endocrinological investigation · 2023Observational
- ISPAD Clinical Practice Consensus Guidelines 2022: Diabetes in adolescence.Pediatric diabetes · 2022Review
- Contraception for Adolescents and Young Women with Type 2 Diabetes-Specific Considerations.Current diabetes reports · 2022Review
- Pregnancy Outcomes in Young Women With Youth-Onset Type 2 Diabetes Followed in the TODAY Study.Diabetes care · 2021Article
- Twenty years of pediatric diabetes surveillance: what do we know and why it matters.Annals of the New York Academy of Sciences · 2021Review
- Dysglycemia in Pregnancy and Maternal/Fetal Outcomes.Journal of women's health (2002) · 2021Article
- Pediatric Type 2 Diabetes: Not a Mini Version of Adult Type 2 Diabetes.Endocrinology and metabolism clinics of North America · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 6 institutions in 1 country.
Funding
Abstract
objectiveWe evaluated pregnancy outcomes, maternal and fetal/neonatal, during the Treatment Options for type 2 Diabetes in Adolescents and Youth (TODAY) study. RESEARCH DESIGN AND
methodsThe TODAY study was a randomized controlled trial comparing three treatment options for youth with type 2 diabetes. Informed consent included the requirement for contraception, including abstinence; this was reinforced at each visit. Following informed consent, self-reported data related to the mother's prenatal care and delivery and the infant's health were retrospectively collected. When permitted, maternal medical records and infant birth records were reviewed.
resultsOf the 452 enrolled female participants, 46 (10.2%) had 63 pregnancies. Despite continued emphasis on adequate contraception, only 4.8% of the pregnant participants reported using contraception prior to pregnancy. The mean age at first pregnancy was 18.4 years; the mean diabetes duration was 3.17 years. Seven pregnancies were electively terminated; three pregnancies had no data reported. Of the remaining 53 pregnancies, 5 (9.4%) resulted in early pregnancy loss, and 7 (13%) resulted in loss with inadequate pregnancy duration data. Two pregnancies ended in stillbirth, at 27 and 37 weeks, and 39 ended with a live-born infant. Of the live-born infants, six (15.4%) were preterm and eight (20.5%) had a major congenital anomaly.
conclusionsDespite diabetes-specific information recommending birth control and the avoidance of pregnancy, 10% of the study participants became pregnant. Pregnancies in youth with type 2 diabetes may be especially prone to result in congenital anomalies. Reasons for the high rate of congenital anomalies are uncertain, but may include poor metabolic control and extreme obesity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.