ArticleBrazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica2016
Effect of (+)-dehydrofukinone on GABAA receptors and stress response in fish model.
Article in Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Chemical Diversity and Biological Activities of Essential Oils fromBiomolecules · 2020Pooled it
- Nano-encapsulatedRSC advances · 2026Article
- Growth, blood biochemistry, intestinal histomorphometry, and disease resistance in Oreochromis niloticus fed diets containing Nectandra grandiflora essential oil.Veterinary research communications · 2025Article
- Essential Oils Distilled from Colombian Aromatic Plants and Their Constituents as Penetration Enhancers for Transdermal Drug Delivery.Molecules (Basel, Switzerland) · 2023Article
- Integrated Network Pharmacology and GC-MS-Based Metabolomics to Investigate the Effect of Xiang-Su Volatile Oil Against Menopausal Depression.Frontiers in pharmacology · 2021Article
- Involvement of GABABioMed research international · 2021Article
- Essential Oils as Stress-Reducing Agents for Fish Aquaculture: A Review.Frontiers in physiology · 2019Review
- Essential Oils and Their Constituents Targeting the GABAergic System and Sodium Channels as Treatment of Neurological Diseases.Molecules (Basel, Switzerland) · 2018Review
- Agarwood Essential Oil Displays Sedative-Hypnotic Effects through the GABAergic System.Molecules (Basel, Switzerland) · 2017Article
- Monoterpenoids (thymol, carvacrol and S-(+)-linalool) with anesthetic activity in silver catfish (Rhamdia quelen): evaluation of acetylcholinesterase and GABAergic activity.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2017Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
(+)-Dehydrofukinone (DHF) is a major component of the essential oil of Nectandra grandiflora (Lauraceae), and exerts a depressant effect on the central nervous system of fish. However, the neuronal mechanism underlying DHF action remains unknown. This study aimed to investigate the action of DHF on GABAA receptors using a silver catfish (Rhamdia quelen) model. Additionally, we investigated the effect of DHF exposure on stress-induced cortisol modulation. Chemical identification was performed using gas chromatography-mass spectrometry and purity was evaluated using gas chromatography with a flame ionization detector. To an aquarium, we applied between 2.5 and 50 mg/L DHF diluted in ethanol, in combination with 42.7 mg/L diazepam. DHF within the range of 10-20 mg/L acted collaboratively in combination with diazepam, but the sedative action of DHF was reversed by 3 mg/L flumazenil. Additionally, fish exposed for 24 h to 2.5-20 mg/L DHF showed no side effects and there was sustained sedation during the first 12 h of drug exposure with 10-20 mg/L DHF. DHF pretreatment did not increase plasma cortisol levels in fish subjected to a stress protocol. Moreover, the stress-induced cortisol peak was absent following pretreatment with 20 mg/L DHF. DHF proved to be a relatively safe sedative or anesthetic, which interacts with GABAergic and cortisol pathways in fish.
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