ArticleScientific reports2015
Defending against pathogens - immunological priming and its molecular basis in a sea anemone, cnidarian.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 64 citations in OpenAlex.
- Epigenetic and metabolic reprogramming of innate immune cells establishes immunological memory in the Schistosomiasis vector snail Biomphalaria glabrata.PLoS pathogens · 2026Article
- Absence of conserved immune signalling pathways and increased pathogen susceptibility associated to photosymbiosis in acoels.BMC biology · 2026Article
- Review
- Unlocking Antimicrobial Peptides from Marine Invertebrates: A Comprehensive Review of Antimicrobial Discovery.Antibiotics (Basel, Switzerland) · 2025Review
- Aquatic Invertebrate Antimicrobial Peptides in the Fight Against Aquaculture Pathogens.Microorganisms · 2025Review
- Prior heat stress increases pathogen susceptibility in the model cnidarian Exaiptasia diaphana.Communications biology · 2024Article
- The coral microbiome: towards an understanding of the molecular mechanisms of coral-microbiota interactions.FEMS microbiology reviews · 2023Article
- Antibiotics reduce bacterial load inAccess microbiology · 2022Article
- Mechanisms and potential immune tradeoffs of accelerated coral growth induced by microfragmentation.PeerJ · 2022Article
- Mesoglea Extracellular Matrix Reorganization during Regenerative Process inInternational journal of molecular sciences · 2021Article
- Microbiome characterization of defensive tissues in the model anemone Exaiptasia diaphana.BMC microbiology · 2021Article
- Proteases as Therapeutic Targets Against the Parasitic CnidarianFrontiers in cellular and infection microbiology · 2021Article
- Trained Immunity inFrontiers in microbiology · 2021Article
- Gene expression kinetics of Exaiptasia pallida innate immune response to Vibrio parahaemolyticus infection.BMC genomics · 2020Article
- The Rapid Regenerative Response of a Model Sea Anemone Species Exaiptasia pallida Is Characterised by Tissue Plasticity and Highly Coordinated Cell Communication.Marine biotechnology (New York, N.Y.) · 2020Article
- Recent advances in vertebrate and invertebrate transgenerational immunity in the light of ecology and evolution.Heredity · 2018Review
- Full allogeneic fusion of embryos in a holothuroid echinoderm.Proceedings. Biological sciences · 2018Article
- Sea anemone model has a single Toll-like receptor that can function in pathogen detection, NF-κB signal transduction, and development.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Long-lasting antiviral innate immune priming in the Lophotrochozoan Pacific oyster, Crassostrea gigas.Scientific reports · 2017Article
- The cellular stress response of the scleractinian coral Goniopora columna during the progression of the black band disease.Cell stress & chaperones · 2017Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cnidarians, in general, are long-lived organisms and hence may repeatedly encounter common pathogens during their lifespans. It remains unknown whether these early diverging animals possess some type of immunological reaction that strengthens the defense response upon repeated infections, such as that described in more evolutionary derived organisms. Here we show results that sea anemones that had previously encountered a pathogen under sub-lethal conditions had a higher survivorship during a subsequently lethal challenge than naïve anemones that encountered the pathogen for the first time. Anemones subjected to the lethal challenge two and four weeks after the sub-lethal exposure presented seven- and five-fold increases in survival, respectively, compared to the naïve anemones. However, anemones challenged six weeks after the sub-lethal exposure showed no increase in survivorship. We argue that this short-lasting priming of the defense response could be ecologically relevant if pathogen encounters are restricted to short seasons characterized by high stress. Furthermore, we discovered significant changes in proteomic profiles between naïve sea anemones and those primed after pathogen exposure suggesting a clear molecular signature associated with immunological priming in cnidarians. Our findings reveal that immunological priming may have evolved much earlier in the tree of life than previously thought.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.