ArticleBMC research notes2015
Bloodstream infections in patients with malignancies: implications for antibiotic treatment in a Ghanaian tertiary setting.
Article in BMC research notes, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.
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Who cites it
38 citing papers in PubMed, 2 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Antimicrobial resistance in bloodstream infections in West Africa: a systematic review and meta-analysis.BMC infectious diseases · 2026Pooled it
- Prevalence, predictors, and mortality of bloodstream infections due to methicillin-resistant Staphylococcus aureus in patients with malignancy: systemic review and meta-analysis.BMC infectious diseases · 2021Pooled it
- Antibiotic susceptibility profile of bacterial isolates in paediatric cancer patients: a prospective cross-sectional study.BMC pediatrics · 2026Article
- A One-Health Perspective onEnvironmental health insights · 2026Review
- Severe outcomes and risk factors of non-neutropenic fever episodes in hospitalized children with cancer in Kenya.Frontiers in oncology · 2025Article
- Bacterial agents and antibiotic resistance in febrile neutropaenia in Africa: A systematic review and meta-analysis.African journal of laboratory medicine · 2025Review
- Etiology, Risk Factors, and Outcomes of Bacteremia in Patients With Hematologic Malignancies and Febrile Neutropenia in Uganda.Open forum infectious diseases · 2024Article
- Aetiology, susceptibility and outcomes of fever in patients receiving chemotherapy in Malawi: a prospective study.JAC-antimicrobial resistance · 2024Article
- Bloodstream infections in cancer patients in central India: pathogens and trends of antimicrobial resistance over a 5-year period.Access microbiology · 2024Article
- Article
- Prevalence of blood stream infections and associated factors among febrile neutropenic cancer patients on chemotherapy at Ocean Road Cancer Institute, Tanzania.Infectious agents and cancer · 2023Article
- Development of a local antibiogram for a teaching hospital in Ghana.JAC-antimicrobial resistance · 2023Article
- Article
- Multicenter Surveillance of Antimicrobial Resistance among Gram-Negative Bacteria Isolated from Bloodstream Infections in Ghana.Antibiotics (Basel, Switzerland) · 2023Article
- Prevalence and antimicrobial resistance profile of bacterial foodborne pathogens in Nile tilapia fish (Frontiers in antibiotics · 2023Article
- Multidrug-Resistant Gram-Negative Bacteria Contaminating Raw Meat Sold in Accra, Ghana.Pathogens (Basel, Switzerland) · 2022Article
- Bloodstream infection in cancer patients; susceptibility profiles of the isolated pathogens, at Khartoum Oncology Hospital, Sudan.African health sciences · 2022Article
- Bacteriological Profile and Antimicrobial Susceptibility Patterns of Gram-Negative Bloodstream Infection and Risk Factors Associated with Mortality and Drug Resistance: A Retrospective Study from Shanxi, China.Infection and drug resistance · 2022Article
- Article
- Multidrug-Resistant Bacteria in Hospital Wastewater of the Korle Bu Teaching Hospital in Accra, Ghana.Environmental health insights · 2022Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBloodstream infections (BSI) remain a major cause of mortality in patients with malignancies. We present the first report on the microbiological profile of bacteraemia and fungaemia among cancer patients in Ghana.
methodsFrom January 2010 through December 2013, we retrospectively analyzed the spectrum of bloodstream pathogens in cancer patients from Korle-Bu Teaching Hospital, Ghana--focusing on multidrug resistant isolates (MDRs).
resultsOverall BSI were confirmed in 22% (n = 93/453) of total blood cultures. Our data highlights a co-dominance of Gram-negative (n = 49/93, 52.6%) and Gram-positive (n = 40/93, 43.0%) bacteria with the former less likely to infect children than adults [odds ratio (OR), 0.56; 95% confidence interval (CI) 0.14-0.91; p value = 0.027]. Staphylococcus epidermidis was the most isolated bacteria (30.1%; n = 28/93). About 61% (n = 25/41) of Enterobacteriaceae isolates were resistant to cefotaxime; a majority (n = 24/25, 96%) of which were MDRs and mostly susceptible to amikacin and levofloxacin. Four (80 %) penicillin resistant streptococci were found; 2 of which were MDRs and sensitive to erythromycin and cefuroxime. Methicillin resistant Staphylococcus aureus and vancomycin resistant enterococci were not identified. In multivariate analysis, the Enterobacteriaceae compared to other organisms were significantly associated with multidrug resistance (adjusted OR, 33.6; 95% CI 6.41-88.73; p value 0.001).
conclusionMDRs, especially cefotaxime resistant Enterobacteriaceae, are common among patients with cancer in our institution but vary among different patient populations. The results show that empiric antibiotic treatment for cancer patients cannot be done effectively without regard for selective antimicrobial use based on local epidemiologic data.
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