ArticleDrug and alcohol dependence2016
Prenatal cocaine exposure, illicit-substance use and stress and craving processes during adolescence.
Article in Drug and alcohol dependence, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Paternal methamphetamine exposure induces higher sensitivity to methamphetamine in male offspring through driving ADRB1 on CaMKII-positive neurons in mPFC.Translational psychiatry · 2023Article
- An intergenerational lifespan perspective on the neuroscience of prenatal substance exposure.Pharmacology, biochemistry, and behavior · 2022Article
- Affect-Related Brain Activity and Adolescent Substance Use: A Systematic Review.Current behavioral neuroscience reports · 2022Article
- Alexithymia, Emotion-Regulation Strategies, and Traumatic Experiences in Prenatally Cocaine-Exposed Young Adults.The American journal on addictions · 2020Article
- Food craving, cortisol and ghrelin responses in modeling highly palatable snack intake in the laboratory.Physiology & behavior · 2019Article
- Sex-Differentiated Associations among Negative Parenting, Emotion-Related Brain Function, and Adolescent Substance Use and Psychopathology Symptoms.Social development (Oxford, England) · 2019Article
- Prenatal drug exposure from infancy through emerging adulthood: Results from neuroimaging.Drug and alcohol dependence · 2019Review
- Neuroendocrine and immune pathways from pre- and perinatal stress to substance abuse.Neurobiology of stress · 2018Review
- Stress reactivity and the developmental psychopathology of adolescent substance use.Neurobiology of stress · 2018Review
- Application of Research Domain Criteria to childhood and adolescent impulsive and addictive disorders: Implications for treatment.Clinical psychology review · 2018Review
- Is Neural Processing of Negative Stimuli Altered in Addiction Independent of Drug Effects? Findings From Drug-Naïve Youth with Internet Gaming Disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Overweight adolescents' brain response to sweetened beverages mirrors addiction pathways.Brain imaging and behavior · 2017Article
- White-matter crossing-fiber microstructure in adolescents prenatally exposed to cocaine.Drug and alcohol dependence · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPrenatal cocaine exposure (PCE) is associated with increased rates of illicit-substance use during adolescence. In addition, both PCE and illicit-substance use are associated with alterations in cortico-striato-limbic neurocircuitry, development of which is ongoing throughout adolescence. However, the relationship between illicit-substance use, PCE and functional neural responses has not previously been assessed concurrently.
methodsSixty-eight adolescents were recruited from an ongoing longitudinal study of childhood and adolescent development. All participants had been followed since birth. Functional magnetic resonance imaging (fMRI) data were acquired during presentation of personalized stressful, favorite-food and neutral/relaxing imagery scripts and compared between 46 PCE and 22 non-prenatally-drug-exposed (NDE) adolescents with and without lifetime illicit-substance use initiation. Data were analyzed using multi-level ANOVAs (pFWE<.05).
resultsThere was a significant three-way interaction between illicit-substance use, PCE status and cue condition on neural responses within primarily cortical brain regions, including regions of the left and right insula. Among PCE versus NDE adolescents, illicit-substance use was associated with decreased subcortical and increased cortical activity during the favorite-food condition, whereas the opposite pattern of activation was observed during the neutral/relaxing condition. Among PCE versus NDE adolescents, illicit-substance use during stress processing was associated with decreased activity in cortical and subcortical regions including amygdala, hippocampus and prefrontal cortex. Neural activity within cortico-striato-limbic regions was significantly negatively associated with subjective ratings of anxiety and craving among illicit-substance users, but not among non-users.
conclusionsThese findings suggest different neural substrates of experimentation with illicit drugs between adolescents with and without in utero cocaine exposure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.