ReviewCritical reviews in biochemistry and molecular biology2016
Towards a compendium of essential genes - From model organisms to synthetic lethality in cancer cells.
Review in Critical reviews in biochemistry and molecular biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 59 citations in OpenAlex.
- Genetic Background and Gene Essentiality.Genes · 2025Article
- Integration of graph neural networks and genome-scale metabolic models for predicting gene essentiality.NPJ systems biology and applications · 2024Article
- Recent advances in the characterization of essential genes and development of a database of essential genes.iMeta · 2024Review
- A Machine Learning Approach for Predicting Essentiality of Metabolic Genes.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Untangling the Context-Specificity of Essential Genes by Means of Machine Learning: A Constructive Experience.Biomolecules · 2023Article
- Article
- Ancestry analysis indicates two different sets of essential genes in eukaryotic model species.Functional & integrative genomics · 2021Article
- Cross-Predicting Essential Genes between Two Model Eukaryotic Species Using Machine Learning.International journal of molecular sciences · 2021Article
- Genome-scale CRISPR screening at high sensitivity with an empirically designed sgRNA library.BMC biology · 2020Article
- RNA-Binding Proteins as Regulators of Migration, Invasion and Metastasis in Oral Squamous Cell Carcinoma.International journal of molecular sciences · 2020Review
- Combined use of feature engineering and machine-learning to predict essential genes inNAR genomics and bioinformatics · 2020Article
- Mutation severity spectrum of rare alleles in the human genome is predictive of disease type.PLoS computational biology · 2020Article
- Predicting gene essentiality inComputational and structural biotechnology journal · 2020Article
- Genome-Wide Interrogation of Human Cancers Identifies EGLN1 Dependency in Clear Cell Ovarian Cancers.Cancer research · 2019Article
- Systematic analysis reveals the prevalence and principles of bypassable gene essentiality.Nature communications · 2019Article
- An Evaluation of Machine Learning Approaches for the Prediction of Essential Genes in Eukaryotes Using Protein Sequence-Derived Features.Computational and structural biotechnology journal · 2019Article
- Variable Dose Analysis: A Novel High-throughput RNAi Screening Method forBio-protocol · 2018Article
- Genomic identification and functional analysis of essential genes in Caenorhabditis elegans.BMC genomics · 2018Article
- Toward an integrated map of genetic interactions in cancer cells.Molecular systems biology · 2018Article
- Emerging and evolving concepts in gene essentiality.Nature reviews. Genetics · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Essential genes are defined by their requirement to sustain life in cells or whole organisms. The systematic identification of essential gene sets not only allows insights into the fundamental building blocks of life, but may also provide novel therapeutic targets in oncology. The discovery of essential genes has been tightly linked to the development and deployment of various screening technologies. Here, we describe how gene essentiality was addressed in different eukaryotic model organisms, covering a range of organisms from yeast to mouse. We describe how increasing knowledge of evolutionarily divergent genomes facilitate identification of gene essentiality across species. Finally, the impact of gene essentiality and synthetic lethality on cancer research and the clinical translation of screening results are highlighted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.