Evidence map›Paper›PMID 26627769›Full record

ArticleThe Journal of the Acoustical Society of America2015

An analysis of cochlear response harmonics: Contribution of neural excitation.

M E Chertoff, A M Kamerer, M Peppi, J T Lichtenhan

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of the Acoustical Society of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

M E ChertoffDepartment of Hearing and Speech, University of Kansas Medical Center, Kansas City, Kansas 66160, USA.
A M KamererDepartment of Hearing and Speech, University of Kansas Medical Center, Kansas City, Kansas 66160, USA.
M PeppiDepartment of Hearing and Speech, University of Kansas Medical Center, Kansas City, Kansas 66160, USA.
J T LichtenhanDepartment of Otolaryngology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
University of Kansas Medical Center · USWashington University in St. Louis · US

Funding

OBJECTIVE MEASURE OF LOW-FREQUENCY INNER EAR FUNCTIONR03DC012844 · NIDCD · WASHINGTON UNIVERSITY · PI LICHTENHAN, JEFFERY · 2012 to 2014
$448k
NIDCD NIH HHS R03 DC012844
6 · The paper itself

Abstract

In this report an analysis of cochlear response harmonics is developed to derive a mathematical function to estimate the gross mechanics involved in the in vivo transfer of acoustic sound into neural excitation (f(Tr)). In a simulation it is shown that the harmonic distortion from a nonlinear system can be used to estimate the nonlinearity, supporting the next phase of the experiment: Applying the harmonic analysis to physiologic measurements to derive estimates of the unknown, in vivo f(Tr). From gerbil ears, estimates of f(Tr) were derived from cochlear response measurements made with an electrode at the round window niche from 85 Hz tone bursts. Estimates of f(Tr) before and after inducing auditory neuropathy-loss of auditory nerve responses with preserved hair cell responses from neurotoxic treatment with ouabain-showed that the neural excitation from low-frequency tones contributes to the magnitude of f(Tr) but not the sigmoidal, saturating, nonlinear morphology.

Indexed as

AcousticsAction PotentialsAnimalsAuditory PathwaysCochleaCochlear NerveComputer SimulationFemaleGerbillinaeHair Cells, AuditoryMechanotransduction, CellularModels, NeurologicalNeurotoxinsNonlinear DynamicsOuabainNeurotoxinsOuabain

Identifiers

PMID26627769
PMCPMC4644149
OpenAlexW2137766921

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.