Evidence map›Paper›PMID 26627552›Full record

ArticleArchives of disease in childhood. Fetal and neonatal edition2016

Growth and development in children born very low birthweight.

Rebecca J Scharf, Annemarie Stroustrup, Mark R Conaway, Mark D DeBoer

Open access · greenAbstract read
In one paragraph

Article in Archives of disease in childhood. Fetal and neonatal edition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 5 pooled it
6.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 5 syntheses or guidelines pooled it, 72 citations in OpenAlex.

  1. Pooled it
  2. Follow-Up of Offspring Born to Parents With a Solid Organ Transplantation: A Systematic Review.Transplant international : official journal of the European Society for Organ Transplantation · 2022
    Pooled it
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  6. Trial
  7. Article
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  10. Missed Early Intervention Opportunities for Children With Autism Spectrum Disorder.Autism research : official journal of the International Society for Autism Research · 2025
    Article
  11. Review
  12. Article
  13. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Rebecca J ScharfDivision of Developmental Pediatrics, Department of Pediatrics, University of Virginia, Charlottesville, Virginia, USA.
Annemarie StroustrupDivision of Newborn Medicine, Department of Pediatrics and Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Mark R ConawayDepartment of Public Health, University of Virginia, Charlottesville, Virginia, USA.
Mark D DeBoerDivision of Pediatric Endocrinology, Department of Pediatrics, University of Virginia, Charlottesville, Virginia, USA.
University of Virginia · USIcahn School of Medicine at Mount Sinai · US

Funding

Chemical Exposures and Infant Outcomes in the Neonatal Intensive Care UnitK23ES022268 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI STROUSTRUP, ANNEMARIE · 2013 to 2017
$731k
NIEHS NIH HHS K23 ES022268
6 · The paper itself

Abstract

objectiveTo examine the relationships between growth (birth to age 2 years) and developmental outcomes in children born with very low birthweight (VLBW).

designMotor and mental development in children born with VLBW were regressed on anthropometric measurements at birth, 9 months and 2 years using multivariable regression.

settingThe Early Childhood Longitudinal Study-Birth Cohort, a longitudinal cohort, community sample, designed to be representative of children born across the USA. PATIENTS: 950 children born with VLBW (<1500 g).

main outcome measuresMotor and cognitive scores on the Bayley Scales at 9 months and 24 months chronological age.

resultsA high proportion of children exhibited poor growth, with length-for-age z-scores <-2 (ie, stunting) in 21.3% of children at 9 months (adjusted for prematurity) and 34.2% of children at 2 years. Compared with children having z-scores >-2, children with growth shortfalls in head circumference, length and weight had a higher adjusted OR (aOR) of low Bayley motor scores at 9 months and 2 years (aOR ranging from 1.8 to 3.3, all p<0.05), while low Bayley cognitive scores were predicted by 9-month deficits in length and weight (aOR 2.0 and 2.4, respectively, both p<0.01) and 2-year deficits in length and head circumference (aOR 2.9 and 2.8, both p<0.05).

conclusionAnthropometric measures of growth were linked to current and future neurodevelopmental outcomes in children born with VLBW. While careful length measures may be a particularly useful marker, deficits in all anthropometric measures were risk factors for developmental delays.

Indexed as

Body HeightBody WeightCephalometryChild, PreschoolDevelopmental DisabilitiesFemaleGrowth DisordersHumansInfantInfant, NewbornInfant, Very Low Birth WeightLongitudinal StudiesMaleMicrocephalyThinnessUnited StatesGrowthNeurodevelopment

Identifiers

PMID26627552
PMCPMC5494252
OpenAlexW2185476401

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.