SynthesisBMC nephrology2015
Genetic predisposition to acute kidney injury--a systematic review.
Synthesis in BMC nephrology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Genetic association studies in critically ill patients: a systematic review.EBioMedicine · 2025Pooled it
- Ethnicity-Stratified Analysis of the Association between TNF-BioMed research international · 2020Pooled it
- Genetic association studies in critically ill patients: protocol for a systematic review.Systematic reviews · 2023Article
- Sepsis-associated acute kidney injury: consensus report of the 28th Acute Disease Quality Initiative workgroup.Nature reviews. Nephrology · 2023Review
- Epidemiology and outcome of an acute kidney injuries in the polytrauma victims admitted at the apex trauma center in Dubai.Acute and critical care · 2023Article
- Association between nitric oxide synthase 3 genetic variant and acute kidney injury following pediatric cardiac surgery.American heart journal · 2022Article
- Morphogenetic dispositions for variability in acute kidney injury after cardiac surgery: Pilot study.Frontiers in medicine · 2022Article
- Genetic Susceptibility to Acute Kidney Injury.Journal of clinical medicine · 2021Review
- Novel roles of the renal angiotensin-converting enzyme.Molecular and cellular endocrinology · 2021Review
- Common Inflammation-Related Candidate Gene Variants and Acute Kidney Injury in 2647 Critically Ill Finnish Patients.Journal of clinical medicine · 2019Article
- Association of genetic polymorphisms with acute kidney injury after cardiac surgery in a Southeast Asian population.PloS one · 2019Article
- Association between inflammatory-response gene polymorphisms and risk of acute kidney injury in children.Bioscience reports · 2018Article
- Cardiac and Vascular Surgery-Associated Acute Kidney Injury: The 20th International Consensus Conference of the ADQI (Acute Disease Quality Initiative) Group.Journal of the American Heart Association · 2018Review
- Between chromatin and SNPs: genetic variability and the susceptibility to acute kidney injury.Critical care (London, England) · 2017Article
- Genetic variants in SERPINA4 and SERPINA5, but not BCL2 and SIK3 are associated with acute kidney injury in critically ill patients with septic shock.Critical care (London, England) · 2017Article
- Surfactant protein-D (SP-D) gene polymorphisms and serum level as predictors of susceptibility and prognosis of acute kidney injury in the Chinese population.BMC nephrology · 2017Article
- Heme Oxygenase-1 Gene Polymorphisms-Toward Precision Medicine for AKI.Journal of the American Society of Nephrology : JASN · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe risk of an individual to develop an acute kidney injury (AKI), or its severity, cannot be reliably predicted by common clinical risk factors. Whether genetic risk factors have an explanatory role poses an interesting question, however. Thus, we conducted a systematic literature review regarding genetic predisposition to AKI or outcome of AKI patients.
methodsWe searched Ovid SP (MEDLINE) and EMBASE databases and found 4027 references to AKI. Based on titles and abstracts, we approved 37 articles for further analysis. Nine were published only as abstracts, leaving 28 original articles in the final analysis. We extracted the first author, year of publication, study design, clinical setting, number of studied patients, patients with AKI, ethnicity of patients, studied polymorphisms, endpoints, AKI definition, phenotype, significant findings, and data for quality scoring from each article. We summarized the findings and scored the quality of articles.
resultsThe articles were quite heterogeneous and of moderate quality (mean 6.4 of 10).
conclusionsDespite different gene polymorphisms with suggested associations with development or severity or outcome of AKI, definitive conclusions would require replication of associations in independent cohort studies and, preferably a hypothesis-free study design.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.