ArticleParasites & vectors2015
Aedes aegypti has spatially structured and seasonally stable populations in Yogyakarta, Indonesia.
Article in Parasites & vectors, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 46 citations in OpenAlex.
- Fine-scale adaptive divergence and population genetic structure of Aedes aegypti in Metropolitan Manila, Philippines.Parasites & vectors · 2024Article
- Article
- Genetic differentiation among Aedes aegypti populations from different eco-geographical zones of India.PLoS neglected tropical diseases · 2023Article
- Population structure and invasion history ofEvolutionary applications · 2023Article
- Bridging landscape ecology and urban science to respond to the rising threat of mosquito-borne diseases.Nature ecology & evolution · 2022Review
- City puzzles: Does urban land scape affect genetic population structure in Aedes aegypti?PLoS neglected tropical diseases · 2022Article
- Novel and Broadly Applicable Microsatellite Markers in Identified Chromosomes of the Philippine Dengue Mosquitoes, Aedes aegypti (Diptera: Culicidae).Journal of medical entomology · 2022Article
- Population Genetic Analysis ofFrontiers in genetics · 2022Article
- The influence of roads on the fine-scale population genetic structure of the dengue vector Aedes aegypti (Linnaeus).PLoS neglected tropical diseases · 2021Article
- Homogeneity and Possible Replacement of Populations of the Dengue VectorsFrontiers in cellular and infection microbiology · 2021Article
- Gene Drive Dynamics in Natural Populations: The Importance of Density Dependence, Space, and Sex.Annual review of ecology, evolution, and systematics · 2020Article
- Genome-wide analysis of diamondback moth, Plutella xylostella L., from Brassica crops and wild host plants reveals no genetic structure in Australia.Scientific reports · 2020Article
- Fine-scale population genetic structure of dengue mosquito vector, Aedes aegypti, in Metropolitan Manila, Philippines.PLoS neglected tropical diseases · 2020Article
- Applying fuzzy logic to assess the biogeographical risk of dengue in South America.Parasites & vectors · 2019Article
- Quantifying the efficacy of genetic shifting in control of mosquito-borne diseases.Evolutionary applications · 2019Article
- Tracking genetic invasions: Genome-wide single nucleotide polymorphisms reveal the source of pyrethroid-resistantEvolutionary applications · 2019Article
- Baseline Characterization of Dengue Epidemiology in Yogyakarta City, Indonesia, before a Randomized Controlled Trial ofThe American journal of tropical medicine and hygiene · 2018Article
- Uncovering vector, parasite, blood meal and microbiome patterns from mixed-DNA specimens of the Chagas disease vector Triatoma dimidiata.PLoS neglected tropical diseases · 2018Article
- Population structure of a vector of human diseases:Ecology and evolution · 2018Article
- Aedes aegypti in the Black Sea: recent introduction or ancient remnant?Parasites & vectors · 2018Article
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDengue fever, the most prevalent global arboviral disease, represents an important public health problem in Indonesia. Control of dengue relies on the control of its main vector, the mosquito Aedes aegypti, yet nothing is known about the population history and genetic structure of this insect in Indonesia. Our aim was to assess the spatio-temporal population genetic structure of Ae. aegypti in Yogyakarta, a densely populated region on Java with common dengue outbreaks.
methodsWe used multiple marker systems (microsatellites, nuclear and mitochondrial genome-wide single nucleotide polymorphisms generated via Restriction-site Associated DNA sequencing) to analyze 979 Ae. aegypti individuals collected from the Yogyakarta city and the surrounding hamlets during the wet season in 2011 and the following dry season in 2012. We employed individual- and group-based approaches for inferring genetic structure.
resultsWe found that Ae. aegypti in Yogyakarta has spatially structured and seasonally stable populations. The spatial structuring was significant for the nuclear and mitochondrial markers, while the temporal structuring was non-significant. Nuclear markers identified three main genetic clusters, showing that hamlets have greater genetic isolation from each other and from the inner city sites. However, one hamlet experienced unrestricted mosquito interbreeding with the inner city, forming a single genetic cluster. Genetic distance was poorly correlated with the spatial distance among mosquito samples, suggesting stronger influence of human-assisted gene flow than active mosquito movement on spatial genetic structure. A star-shaped mitochondrial haplotype network and a significant R(2) test statistic (R(2) = 0.0187, P = 0.001) support the hypothesis that Ae. aegypti in Yogyakarta originated from a small or homogeneous source and has undergone a relatively recent demographic expansion.
conclusionWe report the first insights into the spatio-temporal genetic structure and the underlying processes in the dengue fever mosquito from Yogyakarta, Indonesia. Our results provide valuable information on the effectiveness of local control measures as well as guidelines for the implementation of novel biocontrol strategies such as release of Wolbachia-infected mosquitoes.
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