ReviewAutonomic neuroscience : basic & clinical2016
Sympathetic regulation during thermal stress in human aging and disease.
Review in Autonomic neuroscience : basic & clinical, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it, 106 citations in OpenAlex.
- Air Pollution and Temperature: a Systematic Review of Ubiquitous Environmental Exposures and Sudden Cardiac Death.Current environmental health reports · 2023Pooled it
- Influence of Ambient Temperature on Resting Energy Expenditure in Metabolically Healthy Males and Females.The Journal of nutrition · 2025Trial
- Short-term cocoa bioflavanol supplementation does not improve cold-induced vasodilation in young healthy adults.European journal of applied physiology · 2024Trial
- Deep transcranial magnetic stimulation in combination with skin thermography in obesity: a window on sympathetic nervous system.Acta diabetologica · 2022Trial
- Cardiovascular disease mortality attributable to monthly non-optimal temperature in the united states: a county-level analysis.American journal of preventive cardiology · 2026Article
- Magnitude and variability of blood pressure and renal vascular conductance responses to postural changes, exercise, and cold in black adults: A pilot study.Physiological reports · 2026Article
- Heat stress alters metabolic pathways and nitric oxide signaling in keratinocytes under hyperglycemia.Journal of diabetes investigation · 2026Article
- Cross-Talk Between Signaling and Transcriptional Networks Regulating Thermogenesis-Insights into Canonical and Non-Canonical Regulatory Pathways.International journal of molecular sciences · 2026Review
- Traditional Health Practices May Promote Nrf2 Activation Similar to Exercise.International journal of molecular sciences · 2025Review
- A few degrees, a lot more stress: Associations between room temperature and reactivity to psychosocial stress.Comprehensive psychoneuroendocrinology · 2025Article
- The effect of climate extremes on disability, depression, and cognitive decline in middle-aged and older Chinese adults under different healthy lifestyle.Journal of global health · 2025Observational
- Global excess deaths associated with heatwaves in 2023 and the contribution of human-induced climate change.Innovation (Cambridge (Mass.)) · 2025Article
- Imperatives and co-benefits of research into climate change and neurological disease.Nature reviews. Neurology · 2025Review
- Mechanisms and Efficacy of Contrast Therapy for Musculoskeletal Painful Disease: A Scoping Review.Journal of clinical medicine · 2025Review
- Contribution of physiological dynamics in predicting major depressive disorder severity.Psychophysiology · 2025Article
- Blunted cardiovascular responses in individuals with type 2 diabetes and hypertension during cold and heat exposure.Frontiers in physiology · 2025Article
- Coherence analysis of peripheral blood flow signals is a potential method for evaluating autonomic nervous system function.Frontiers in physiology · 2025Article
- Association between outdoor temperature and bath-related drowning deaths in Japan (1995-2020): modifying factors and the role of prefectural characteristics.Environmental health and preventive medicine · 2025Article
- New York State Climate Impacts Assessment Chapter 07: Human Health and Safety.Annals of the New York Academy of Sciences · 2024Review
- Lower maximal skin wettedness in both warm-humid and hot-dry environments with advanced age (PSU HEAT project).Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Humans control their core temperature within a narrow range via precise adjustments of the autonomic nervous system. In response to changing core and/or skin temperature, several critical thermoregulatory reflex effector responses are initiated and include shivering, sweating, and changes in cutaneous blood flow. Cutaneous vasomotor adjustments, mediated by modulations in sympathetic nerve activity (SNA), aid in the maintenance of thermal homeostasis during cold and heat stress since (1) they serve as the first line of defense of body temperature and are initiated before other thermoregulatory effectors, and (2) they are on the efferent arm of non-thermoregulatory reflex systems, aiding in the maintenance of blood pressure and organ perfusion. This review article highlights the sympathetic responses of humans to thermal stress, with a specific focus on primary aging as well as impairments that occur in both heart disease and type 2 diabetes mellitus. Age- and pathology-related changes in efferent muscle and skin SNA during cold and heat stress, measured directly in humans using microneurography, are discussed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.