ArticleProceedings of the National Academy of Sciences of the United States of America2015
Responsiveness of G protein-coupled odorant receptors is partially attributed to the activation mechanism.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Elucidating odorant synergy in red wine: through olfactory receptor-based profiling.NPJ science of food · 2026Article
- Pyrfume: A window to the world's olfactory data.Scientific data · 2024Article
- An efficient behavioral screening platform classifies natural products and other chemical cues according to their chemosensory valence inbioRxiv : the preprint server for biology · 2024Article
- Two odorant receptors regulate 1-octen-3-ol induced oviposition behavior in the oriental fruit fly.Communications biology · 2023Article
- Article
- Interactions among key residues regulate mammalian odorant receptor trafficking.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022Article
- Large-Scale G Protein-Coupled Olfactory Receptor-Ligand Pairing.ACS central science · 2022Article
- A 3D transcriptomics atlas of the mouse nose sheds light on the anatomical logic of smell.Cell reports · 2022Article
- Functional analysis of human olfactory receptors with a high basal activity using LNCaP cell line.PloS one · 2022Article
- Functional Architecture of Deleterious Genetic Variants in the Genome of a Wrangel Island Mammoth.Genome biology and evolution · 2020Article
- A two-stage computational approach to predict novel ligands for a chemosensory receptor.Current research in structural biology · 2020Article
- Primacy coding facilitates effective odor discrimination when receptor sensitivities are tuned.PLoS computational biology · 2019Article
- Characterizing novel olfactory receptors expressed in the murine renal cortex.American journal of physiology. Renal physiology · 2019Article
- Zebrafish olfactory receptors ORAs differentially detect bile acids and bile salts.The Journal of biological chemistry · 2019Article
- Real-time In Vitro Monitoring of Odorant Receptor Activation by an Odorant in the Vapor Phase.Journal of visualized experiments : JoVE · 2019Article
- Mammalian class I odorant receptors exhibit a conserved vestibular-binding pocket.Cellular and molecular life sciences : CMLS · 2019Article
- Spheroid Culture of Mammalian Olfactory Receptor Neurons: Potential Applications for a Bioelectronic Nose.Experimental neurobiology · 2018Article
- Vapor detection and discrimination with a panel of odorant receptors.Nature communications · 2018Article
- Odorant Receptor 7D4 Activation Dynamics.Angewandte Chemie (International ed. in English) · 2018Article
- Structure-Function Relationships of Olfactory and Taste Receptors.Chemical senses · 2018Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Mammals detect and discriminate numerous odors via a large family of G protein-coupled odorant receptors (ORs). However, little is known about the molecular and structural basis underlying OR response properties. Using site-directed mutagenesis and computational modeling, we studied ORs sharing high sequence homology but with different response properties. When tested in heterologous cells by diverse odorants, MOR256-3 responded broadly to many odorants, whereas MOR256-8 responded weakly to a few odorants. Out of 36 mutant MOR256-3 ORs, the majority altered the responses to different odorants in a similar manner and the overall response of an OR was positively correlated with its basal activity, an indication of ligand-independent receptor activation. Strikingly, a single mutation in MOR256-8 was sufficient to confer both high basal activity and broad responsiveness to this receptor. These results suggest that broad responsiveness of an OR is at least partially attributed to its activation likelihood.
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