ArticleProceedings of the National Academy of Sciences of the United States of America2015
Genomic insights into the evolutionary origin of Myxozoa within Cnidaria.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers.
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104 citing papers in PubMed.
- The Dayhoff Exchange Score: A New Metric to Quantify Entropic Site Saturation in Amino Acid Data Sets Prior to Phylogenetic Analysis.Systematic biology · 2026Article
- The shortest animal introns: insights from parasitic cnidarians.Molecular biology and evolution · 2026Article
- Single-cell analyses of tissue regeneration in two true jellyfish.Molecular biology and evolution · 2026Article
- The first chromosome-level cubozoan genome differentiates unique and common features in different cnidarian lineages.BMC biology · 2026Article
- Smolstatin1, a unique cystatin-like stefin ofCurrent research in microbial sciences · 2026Article
- Myxozoan parasite genomes assembled from contaminated host data reveal extensive gene order conservation and rapid sequence evolution.G3 (Bethesda, Md.) · 2025Article
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- Cnidarian toxins: omics approaches and recombinant proteins.The journal of venomous animals and toxins including tropical diseases · 2025Article
- Life Cycle Transitions in the Freshwater JellyfishBiology · 2024Article
- Saltational Episodes of Reticulate Evolution in the Drosophila saltans Species Group.Molecular biology and evolution · 2024Article
- Disentangling cobionts and contamination in long-read genomic data using sequence composition.G3 (Bethesda, Md.) · 2024Article
- Description, life cycle, and development of the myxozoanInternational journal for parasitology. Parasites and wildlife · 2024Article
- Evolution of myxozoan mitochondrial genomes: insights from myxobolids.BMC genomics · 2024Article
- Fluorescence In Situ Hybridization as a Tool for Studying the Specification and Differentiation of Cell Types in Nematostella vectensis.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Myxobolus dumerilii sp. n. (Myxozoa: Myxobolidae) infecting the brain of Chinese longsnout catfish Tachysurus dumerili (Bleeker) in China.Systematic parasitology · 2023Article
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- The Molecular Mechanisms Employed by the ParasiteInternational journal of molecular sciences · 2023Article
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- Coevolution of the Tlx homeobox gene with medusa development (Cnidaria: Medusozoa).Communications biology · 2023Article
- GenomeFLTR: filtering reads made easy.Nucleic acids research · 2023Article
44 more citing papers are in PubMed but not listed here.
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7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The Myxozoa comprise over 2,000 species of microscopic obligate parasites that use both invertebrate and vertebrate hosts as part of their life cycle. Although the evolutionary origin of myxozoans has been elusive, a close relationship with cnidarians, a group that includes corals, sea anemones, jellyfish, and hydroids, is supported by some phylogenetic studies and the observation that the distinctive myxozoan structure, the polar capsule, is remarkably similar to the stinging structures (nematocysts) in cnidarians. To gain insight into the extreme evolutionary transition from a free-living cnidarian to a microscopic endoparasite, we analyzed genomic and transcriptomic assemblies from two distantly related myxozoan species, Kudoa iwatai and Myxobolus cerebralis, and compared these to the transcriptome and genome of the less reduced cnidarian parasite, Polypodium hydriforme. A phylogenomic analysis, using for the first time to our knowledge, a taxonomic sampling that represents the breadth of myxozoan diversity, including four newly generated myxozoan assemblies, confirms that myxozoans are cnidarians and are a sister taxon to P. hydriforme. Estimations of genome size reveal that myxozoans have one of the smallest reported animal genomes. Gene enrichment analyses show depletion of expressed genes in categories related to development, cell differentiation, and cell-cell communication. In addition, a search for candidate genes indicates that myxozoans lack key elements of signaling pathways and transcriptional factors important for multicellular development. Our results suggest that the degeneration of the myxozoan body plan from a free-living cnidarian to a microscopic parasitic cnidarian was accompanied by extreme reduction in genome size and gene content.
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