ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2016
Health-related quality of life in Parkinson's: impact of 'off' time and stated treatment preferences.
Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Systematic Review of the Effect of a One-Day Versus Seven-Day Recall Duration on Patient Reported Outcome Measures (PROMs).The patient · 2023Pooled it
- Discrete Choice Experiments in Health Economics: Past, Present and Future.PharmacoEconomics · 2019Pooled it
- Trial
- Article
- Exploring Preferences and Priorities in Advanced Parkinson's Disease: A Discrete Choice Experiment.Neurology and therapy · 2026Article
- Real-World Use of COMT Inhibitors in the Management of Patients with Parkinson's Disease in Spain Who Present Early Motor Fluctuations: Interim Results from the REONPARK Study.Brain sciences · 2025Article
- The Cost-Effectiveness of Opicapone Versus Entacapone as Adjuvant Therapy for Levodopa-Treated Individuals With Parkinson's Disease Experiencing End-of-Dose Motor Fluctuations.Parkinson's disease · 2025Article
- Acceptability of the routine use and collection of a generic patient reported outcome measure from the perspective of healthcare staff: a qualitative study.Journal of patient-reported outcomes · 2023Article
- Patients' Preferences for Adjunctive Parkinson's Disease Treatments: A Discrete-Choice Experiment.Patient preference and adherence · 2023Article
- Why do 'OFF' periods still occur during continuous drug delivery in Parkinson's disease?Translational neurodegeneration · 2022Review
- Opicapone for the Treatment of Parkinson's Disease "Off" Episodes: Pharmacology and Clinical Considerations.Clinical drug investigation · 2022Review
- Opicapone, a Novel Catechol-O-methyl Transferase Inhibitor, for Treatment of Parkinson's Disease "Off" Episodes.Health psychology research · 2022Article
- How to measure fluctuating impairments in people with MS: development of an ambulatory assessment version of the EQ-5D-5L in an exploratory study.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2021Article
- Impact of Off Periods on Persons With Parkinson Disease and Care Partners: A Qualitative Study.Neurology. Clinical practice · 2021Article
- The Experience of OFF Periods in Parkinson's Disease: Descriptions, Triggers, and Alleviating Factors.Journal of patient-centered research and reviews · 2021Article
- Patient Preferences for Treating "OFF" Episodes in Parkinson's Disease: A Discrete Choice Experiment.Patient preference and adherence · 2021Article
- Patient preferences in Italy: health state utilities associated with attributes of weekly injection devices for treatment of type 2 diabetes.Patient preference and adherence · 2018Article
- Understanding, Impact, and Communication of "Off" Periods in Parkinson's Disease: A Scoping Review.Movement disorders clinical practiceArticle
- Discrepancies in symptom concerns and burden from the perspectives of parkinson's disease patients, caregivers, and physicians.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeLong-term levodopa therapy and related fluctuating plasma concentrations are associated with between-dose periods of 'off time' resulting in substantial variation in symptoms and functioning throughout the day in people with Parkinson's (PwP).
methodsPwP across UK, France, Spain and Italy completed an online survey to explore: the impact of 'off time' on (1) health-related quality of life (HRQL) and (2) on functioning and ability to undertake usual activities; (3) the value of 'off time' relative to other factors associated with Parkinson's through a stated preference discrete choice experiment (SPDCE).
resultsIn total, 305 PwP completed the online survey. Overall mean HRQL (utility) score was significantly lower for 'off time' (0.37) than for 'on time' (0.60). All attributes within the SPDCE were significant predictors of treatment choice, although increased duration of 'on time' (per hour per day: odds ratio (OR) = 1.40) and predictability of 'off time' to within 30 min (OR = 1.42) were valued most highly.
conclusions'On time' and predictability of 'off time' are highly valued by PwP. Due to substantial diurnal variation of Parkinson's symptoms, standard patient-reported outcome (PRO) assessments may not adequately capture the impact of 'off time' on HRQL and participation in daily activities.
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