ReviewCurrent obesity reports2015
Adaptive Thermogenesis in Resistance to Obesity Therapies: Issues in Quantifying Thrifty Energy Expenditure Phenotypes in Humans.
Review in Current obesity reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 45 citations in OpenAlex.
- A randomized parallel-designed study evaluating the effect of an app-based nutritional concept for weight reduction and further cardiovascular risk factors: Insights from the PreVA study.Frontiers in nutrition · 2026Trial
- Efficacy of providing energy expenditure information to guide weight loss interventions in people with obesity: A randomized controlled trial.Clinical obesity · 2025Trial
- Metabolic adaptation is an illusion, only present when participants are in negative energy balance.The American journal of clinical nutrition · 2020Trial
- Longitudinal Changes in Body Composition, Adaptive Thermogenesis, and Muscle Strength in Patients with Obesity Treated with Semaglutide.Obesity facts · 2026Article
- The effect of divergent selection on the basal metabolic rate on body temperature in males of laboratory mice with different levels of obesity.International journal of obesity (2005) · 2026Article
- Adaptive thermogenesis driving catch-up fat during weight regain: a role for skeletal muscle hypothyroidism and a risk for sarcopenic obesity.Reviews in endocrine & metabolic disorders · 2025Review
- Body Temperature, Metabolic, and Circulatory Changes After 8 Days of Water-Only Fasting in Healthy Middle-Aged Men.Journal of clinical medicine · 2025Article
- Comparative analysis of combined exercise programs in middle-aged obese males: impact on energy expenditure, body composition, and metabolic rate.Frontiers in sports and active living · 2025Article
- Adipose Tissue-Resident Sphingomonas Paucimobilis Suppresses Adaptive Thermogenesis by Reducing 15-HETE Production and Inhibiting AMPK Pathway.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Article
- What could be the reasons for not losing weight even after following a weight loss program?Journal of health, population, and nutrition · 2024Review
- Resting energy expenditure depends on energy intake during weight loss in people with obesity: a retrospective cohort study.Archives of endocrinology and metabolism · 2023Article
- Metabolic adaptation after combined resistance and aerobic exercise training in older women.Obesity (Silver Spring, Md.) · 2022Article
- Metabolic adaptation delays time to reach weight loss goals.Obesity (Silver Spring, Md.) · 2022Article
- Metabolic adaptation is associated with less weight and fat mass loss in response to low-energy diets.Nutrition & metabolism · 2021Article
- Describing the Weight-Reduced State: Physiology, Behavior, and Interventions.Obesity (Silver Spring, Md.) · 2021Article
- The Role of Leptin in the Development of Energy Homeostatic Systems and the Maintenance of Body Weight.Frontiers in physiology · 2021Review
- Revisiting the Compensatory Theory as an explanatory model for relapse in obesity management.The American journal of clinical nutrition · 2020Article
- Metabolic adaptation is not a major barrier to weight-loss maintenance.The American journal of clinical nutrition · 2020Article
- Metabolic Factors Determining the Susceptibility to Weight Gain: Current Evidence.Current obesity reports · 2020Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dieting and exercise are likely to remain the core approaches in the management of obesity in the foreseeable future despite their well-documented failures for achieving long-term weight loss. Explanations for such poor prognosis are centered on patient's self-regulatory failure and lack of compliance to the prescribed diet or exercise regimen. While a role for physiological adaptations leading to diminished rates of heat production has also been advocated, there are considerable uncertainties about the quantitative importance of such regulated heat production (i.e., adaptive thermogenesis) to the less-than-expected weight loss and ease for weight regain. This paper first reviews the most compelling evidence of what is often considered as weight loss-induced adaptive thermogenesis in various compartments of daily energy expenditure. It then discusses the major limitations and issues in quantifying such thrifty energy expenditure phenotypes and underscores the plausibility of diminished core temperature as a thrifty metabolic trait in resistance to weight loss. Although an accurate quantification of adaptive thermogenesis will have to await the applications of deep body composition phenotyping and better discrimination of physical activity energy expenditures, the magnitude of diminished energy expenditure in response to weight loss in certain individuals is large enough to support the concept that adaptive thermogenesis contribute importantly to their resistance to obesity therapies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.