ArticleBMC nephrology2015
The chronic kidney disease epidemiology collaboration equation combining creatinine and cystatin C accurately assesses renal function in patients with cirrhosis.
Article in BMC nephrology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- Glomerular filtration rate estimation in nephrotic patients: creatinine and/or cystatin-C-based equations, or none of them?Clinical kidney journal · 2026Article
- Evaluation of Kidney Function in Cirrhosis: Methods and Pitfalls.Diagnostics (Basel, Switzerland) · 2026Review
- Impact of hepatitis C therapy on urinary outcomes and renal function: a prospective real-world cohort study of early kidney changes.BMC nephrology · 2026Article
- SPAP: Soluble Human Plasma Proteoform Analysis via Acetonitrile Precipitation and Top-Down Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2026Article
- Comparative Evaluation of Kidney Function Using Cystatin C and Serum Creatinine in Cirrhosis Patients: A Prospective Cross-Sectional Study.Health science reports · 2025Article
- Frailty and the Risk of Acute Kidney Injury Among Patients With Cirrhosis.Hepatology communications · 2022Article
- Chronic renal dysfunction in cirrhosis: A new frontier in hepatology.World journal of gastroenterology · 2021Article
- Cystatin C as a biomarker of chronic kidney disease: latest developments.Expert review of molecular diagnostics · 2020Review
- Estimation versus measurement of the glomerular filtration rate for kidney function assessment in patients with cancer undergoing cisplatin-based chemotherapy.Scientific reports · 2020Observational
- Chronic Kidney Disease in Liver Transplant Candidates: A Rising Burden Impacting Post-Liver Transplant Outcomes.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2020Article
- Cystatin C: A Primer for Pharmacists.Pharmacy (Basel, Switzerland) · 2020Review
- Effect of terlipressin on renal function in cirrhotic patients with acute upper gastrointestinal bleeding.Annals of translational medicine · 2020Article
- Association Between Renal Function Pattern and Mortality in Patients With Cirrhosis.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2019Article
- Changes in Simultaneous Liver-kidney Transplant Allocation Policy May Impact Postliver Transplant Outcomes.Transplantation · 2019Article
- Methods of Estimating Kidney Function for Drug Dosing in Special Populations.Clinical pharmacokinetics · 2018Review
- Diagnostic and prognostic value of galectin-3, serum creatinine, and cystatin C in chronic kidney diseases.Journal of clinical laboratory analysis · 2017Article
- Renal dysfunction in cirrhosis: acute kidney injury and the hepatorenal syndrome.Gastroenterology report · 2017Article
- Comparison of Performance of Improved Serum Estimators of Glomerular Filtration Rate (GFR) toJournal of nuclear medicine technology · 2017Article
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Authors and funding
15 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAccurate measurement of renal function in cirrhotic patients is still challenging. To find the best test for the determination of the true glomerular filtration rate (GFR) in cirrhotic patients this study prospectively compared measured (m)GFR, the gold standard, with estimated (e)GFR using equations based on serum levels of creatinine and cystatin C.
methodsGFR was measured by sinistrin clearance using the bolus method in 50 patients with cirrhosis (Child Turcotte Pugh score A, B and C) and 24 age-matched healthy subjects as controls. Measured (m)GFR was compared to eGFR using bias, accuracy 10 % and 30 %, as well as correlation coefficients.
resultsCreatinine-based equations generally overestimated GFR in patients with cirrhosis and showed a bias (average difference between mGFR and eGFR) of -40 (CG), -12 (MDRD) and -9 (CKD-EPI-Cr) ml/min/1.73 m(2). Cystatin C-based equations underestimated GFR, especially in patients with Child Turcotte Pugh score C (bias 17 ml/min/1.73 m(2)for CKD-EPI-CysC). Of these equations, the CKD-EPI equation that combines creatinine and cystatin C (CKD-EPI-Cr-CysC) showed a bias of 0.12 ml/min/1.73 m(2) as compared to measured GFR.
conclusionsThe CKD-EPI equation that combines serum creatinine and cystatin C measurements shows the best performance for accurate estimation of GFR in cirrhosis, especially at advanced stages.
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