ArticleJournal of neuroinflammation2015
Thalamic inflammation after brain trauma is associated with thalamo-cortical white matter damage.
Article in Journal of neuroinflammation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.
- The second decade of DTI in TBI Part 2: a systematic review of moderate and severe TBI.Frontiers in neurologyPooled it
- Autologous adipose-derived mesenchymal stromal cells for chronic traumatic brain injury.Brain : a journal of neurology · 2026Article
- Pontine pathology mediates common symptoms of blast-induced chronic mild traumatic brain injury.Brain communications · 2026Article
- Inflammation of central nervous system fiber tracts is active in patients over six months post-intracerebral hemorrhage.Acta neuropathologica communications · 2025Article
- Inflammatory, White Matter, and Neurodegenerative Mechanisms in Fluid Ability Decrements in Chronic Mild-to-Moderate Traumatic Brain Injury.Journal of neurotrauma · 2025Article
- Cortical Morphometric Similarity Remodeling in Traumatic Brain Injury Links Cognitive Impairments with Transcriptional Changes and Type-Specific Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Computational Modelling of Protected and Unprotected Head Impacts in Rugby.Bioengineering (Basel, Switzerland) · 2025Article
- Traumatic Brain Injury Promotes Neurogenesis and Oligodendrogenesis in Subcortical Brain Regions of Mice.Cells · 2025Article
- Bundle-specific tractography approach for identifying white matter microstructural changes following traumatic brain injury in rats: An EpiBioS4Rx study.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Reactive Microglia and Astrocytes as Therapeutic Targets in Prion Diseases.Sub-cellular biochemistry · 2025Review
- Neuroinflammatory Response in the Traumatic Brain Injury: An Update.Neurochemical research · 2024Review
- Systemic inflammation following traumatic injury and its impact on neuroinflammatory gene expression in the rodent brain.Journal of neuroinflammation · 2024Article
- Translating Molecular Approaches to Oligodendrocyte-Mediated Neurological Circuit Modulation.Brain sciences · 2024Review
- Neuroimmune activation is associated with neurological outcome in anoxic and traumatic coma.Brain : a journal of neurology · 2024Article
- Neutralization of Interleukin 1-beta is associated with preservation of thalamic capillaries after experimental traumatic brain injury.Frontiers in neurology · 2024Article
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- Inflammaging, cellular senescence, and cognitive aging after traumatic brain injury.Neurobiology of disease · 2023Review
- Enhancing GAT-3 in thalamic astrocytes promotes resilience to brain injury in rodents.Science translational medicine · 2022Article
- Innate Immune Cell-Related Pathology in the Thalamus Signals a Risk for Disability Progression in Multiple Sclerosis.Neurology(R) neuroimmunology & neuroinflammation · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundTraumatic brain injury can trigger chronic neuroinflammation, which may predispose to neurodegeneration. Animal models and human pathological studies demonstrate persistent inflammation in the thalamus associated with axonal injury, but this relationship has never been shown in vivo.
findingsUsing [(11)C]-PK11195 positron emission tomography, a marker of microglial activation, we previously demonstrated thalamic inflammation up to 17 years after traumatic brain injury. Here, we use diffusion MRI to estimate axonal injury and show that thalamic inflammation is correlated with thalamo-cortical tract damage.
conclusionsThese findings support a link between axonal damage and persistent inflammation after brain injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.