Evidence map›Paper›PMID 26627175›Full record

ArticleBMC bioinformatics2015

Scalable analysis of Big pathology image data cohorts using efficient methods and high-performance computing strategies.

Tahsin Kurc, Xin Qi, Daihou Wang, Fusheng Wang, George Teodoro, Lee Cooper, Michael Nalisnik, Lin Yang, Joel Saltz, David J Foran

Abstract read
In one paragraph

Article in BMC bioinformatics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. AI in Medical Imaging Informatics: Current Challenges and Future Directions.IEEE journal of biomedical and health informatics · 2020
    Article
  5. Article
  6. Parallel and Efficient Sensitivity Analysis of Microscopy Image Segmentation Workflows in Hybrid Systems.Proceedings. IEEE International Conference on Cluster Computing · 2017
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tahsin KurcDepartment of Biomedical Informatics, Stony Brook University, Stony Brook, USA. tahsin.kurc@stonybrook.edu.
Xin QiDepartment of Pathology & Laboratory Medicine, Rutgers -- Robert Wood Johnson Medical School, New Brunswick, USA. qixi@rutgers.edu.
Daihou WangDepartment of Electrical and Computer Engineering, Rutgers University, New Brunswick, USA. daihou.wang@rutgers.edu.
Fusheng WangDepartment of Biomedical Informatics, Stony Brook University, Stony Brook, USA. fusheng.wang@stonybrook.edu.
George TeodoroDepartment of Biomedical Informatics, Stony Brook University, Stony Brook, USA. teodoro@unb.br.
Lee CooperDepartment of Biomedical Informatics, Emory University, Atlanta, USA. lee.cooper@emory.edu.
Michael NalisnikDepartment of Biomedical Informatics, Emory University, Atlanta, USA. mnalisn@emory.edu.
Lin YangDepartment of Biomedical Engineering, University of Florida, Gainesville, USA. lin.yang@bme.ufl.edu.
Joel SaltzDepartment of Biomedical Informatics, Stony Brook University, Stony Brook, USA. joel.saltz@stonybrookmedicine.edu.
David J ForanDepartment of Pathology & Laboratory Medicine, Rutgers -- Robert Wood Johnson Medical School, New Brunswick, USA. foran@cinj.rutgers.edu.

Funding

TRANSCRIPTIONAL PROFILINGP30CA072720 · NCI · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI Tracie Saunders · 1997 to 2026
$94.5M
Image Mining for Comparative Analysis of Expression Patterns in Tissue MicroarrayR01LM009239 · NLM · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI FORAN, DAVID J, SALTZ, JOEL H. · 2007 to 2016
$4.5M
Advanced Development of an Open-source Platform for Web-based Integrative Digital Image Analysis in CancerU24CA194362 · NCI · EMORY UNIVERSITY · PI COOPER, LEE, GUTMAN, DAVID ANDREW · 2015 to 2019
$3.6M
Tools to Analyze Morphology and Spatially Mapped Molecular DataU24CA180924 · NCI · STATE UNIVERSITY NEW YORK STONY BROOK · PI SALTZ, JOEL H. · 2014 to 2019
$3.6M
Informatics for Integrative Brain Tumor Whole Slide AnalysisR01LM011119 · NLM · STATE UNIVERSITY NEW YORK STONY BROOK · PI FORAN, DAVID J, SALTZ, JOEL H. · 2011 to 2014
$1.8M
Development and Dissemination of MuscleMiner: An Imaging Informatics Tool for MusR01AR065479 · NIAMS · UNIVERSITY OF FLORIDA · PI DING, MINGZHOU · 2014 to 2018
$1.8M
Collaborative Systems for Analyzing Tissue MicroarraysR01CA156386 · NCI · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI FORAN, DAVID J · 2010 to 2014
$1.7M
Mechano-Visual Phenotyping of Cancer: From Onset Through Disease ProgressionR01CA161375 · NCI · UNIV OF MARYLAND, COLLEGE PARK · PI DESAI, JAYDEV P., FORAN, DAVID J · 2012 to 2016
$1.6M
CCR NIH HHS HHSN261200800001CNCI NIH HHS 1U24CA180924-01A1NCI NIH HHS HHSN261200800001ENCI NIH HHS P30 CA072720NCI NIH HHS R01 CA156386NCI NIH HHS R01 CA161375NCI NIH HHS U24 CA180924NCI NIH HHS U24 CA194362NIAMS NIH HHS R01 AR065479NLM NIH HHS 5R01LM009239-07NLM NIH HHS 5R01LM011119-05NLM NIH HHS R01 LM009239NLM NIH HHS R01 LM011119
6 · The paper itself

Abstract

backgroundWe describe a suite of tools and methods that form a core set of capabilities for researchers and clinical investigators to evaluate multiple analytical pipelines and quantify sensitivity and variability of the results while conducting large-scale studies in investigative pathology and oncology. The overarching objective of the current investigation is to address the challenges of large data sizes and high computational demands.

resultsThe proposed tools and methods take advantage of state-of-the-art parallel machines and efficient content-based image searching strategies. The content based image retrieval (CBIR) algorithms can quickly detect and retrieve image patches similar to a query patch using a hierarchical analysis approach. The analysis component based on high performance computing can carry out consensus clustering on 500,000 data points using a large shared memory system.

conclusionsOur work demonstrates efficient CBIR algorithms and high performance computing can be leveraged for efficient analysis of large microscopy images to meet the challenges of clinically salient applications in pathology. These technologies enable researchers and clinical investigators to make more effective use of the rich informational content contained within digitized microscopy specimens.

Indexed as

AlgorithmsInformation Storage and RetrievalPattern Recognition, AutomatedCluster AnalysisDiagnostic ImagingHumansImage Interpretation, Computer-AssistedMaleNeoplasm GradingProstatic NeoplasmsTissue Array Analysis

Identifiers

PMID26627175
PMCPMC4667532

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.