Evidence map›Paper›PMID 26627105›Full record

SynthesisJournal of acquired immune deficiency syndromes (1999)2016

Elevations in Serum Creatinine With Tenofovir-Based HIV Pre-Exposure Prophylaxis: A Meta-Analysis of Randomized Placebo-Controlled Trials.

Rabi Yacoub, Girish N Nadkarni, Damian Weikum, Ioannis Konstantinidis, Anna Boueilh, Robert M Grant, Kenneth K Mugwanya, Jared M Baeten, Christina M Wyatt

Abstract readLetterMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of acquired immune deficiency syndromes (1999), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Canadian guideline on HIV pre-exposure prophylaxis and nonoccupational postexposure prophylaxis.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2017
    Guideline
  3. Trial
  4. Trial
  5. Article
  6. Article
  7. Article
  8. Retrospective audit of a convenience cohort of individuals on HIV pre-exposure prophylaxis in Alberta, Canada.Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2022
    Article
  9. Pre-exposure prophylaxis for HIV: effective and underused.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2022
    Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Setting the stage for expanding HIV pre-exposure prophylaxis use in Canada.Canada communicable disease report = Releve des maladies transmissibles au Canada · 2017
    Article
  16. Kidney Disease in HIV: Moving beyond HIV-Associated Nephropathy.Journal of the American Society of Nephrology : JASN · 2017
    Review
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 3 countries.

Rabi Yacoub*Division of Nephrology, Department of Medicine, University at Buffalo, Buffalo, NY †Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY ‡Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT §Department of Nephrology-Transplantation-Dialysis, Bordeaux Hospital, Bordeaux, France ‖Gladstone Institutes, University of California, San Francisco and the San Francisco AIDS Foundation, San Francisco, CA ¶Department of Epidemiology, University of Washington, Seattle, WA #Departments of Global Health, Medicine, and Epidemiology, University of Washington, Seattle, WA.
Girish N Nadkarni
Damian Weikum
Ioannis Konstantinidis
Anna Boueilh
Robert M Grant
Kenneth K Mugwanya
Jared M Baeten
Christina M Wyatt
Apple (Israel) · IL

Funding

VIRAL PATHOGENESIS OF HIV ASSOCIATED NEPHROPATHYP01DK056492 · NIDDK · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI KLOTMAN, MARY E. · 1999 to 2021
$27.8M
Mount Sinai Nephrology Research Training GrantT32DK007757 · NIDDK · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI CAMPBELL, KIRK N, HE, JOHN CIJIANG · 1998 to 2022
$3.8M
Incidence and Implications of Subclinical Kidney Injury with Tenofovir based PrEPR01DK100272 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI WYATT, CHRISTINA M · 2014 to 2016
$1.8M
NIDDK NIH HHS P01 DK056492NIDDK NIH HHS P01DK056492NIDDK NIH HHS R01 DK100272NIDDK NIH HHS T32 DK007757NIDDK NIH HHS T32DK00775716
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Pre-Exposure ProphylaxisAnti-HIV AgentsCreatinineDrug Therapy, CombinationHIV InfectionsHumansRandomized Controlled Trials as TopicTenofovirAnti-HIV AgentsCreatinineTenofovir

Identifiers

PMID26627105
PMCPMC4767606
OpenAlexW2181898081

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.