ArticleToxicology and applied pharmacology2016
Inhibition of poly(ADP-ribose)polymerase-1 and DNA repair by uranium.
Article in Toxicology and applied pharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 62 citations in OpenAlex.
- Synergistic Adsorption and Fluorescence in Porous Aromatic Frameworks for Highly Sensitive Detection of Radioactive Uranium.Molecules (Basel, Switzerland) · 2025Article
- Zinc as a Mechanism-Based Strategy for Mitigation of Metals Toxicity.Current environmental health reports · 2025Review
- T'ah kóó hóniidló, we're still HERE! Mining legacies, Indigenous health and innovative solutions.Frontiers in public health · 2024Article
- Article
- Juxtaposition of intensive agriculture, vulnerable aquifers, and mixed chemical/microbial exposures in private-well tapwater in northeast Iowa.The Science of the total environment · 2023Article
- Bottled water contaminant exposures and potential human effects.Environment international · 2023Article
- Metal mixture exposures and multiplexed autoantibody screening in Navajo communities exposed to uranium mine wastes.Journal of translational autoimmunity · 2023Article
- Tapwater Exposures, Effects Potential, and Residential Risk Management in Northern Plains Nations.ACS ES&T water · 2022Article
- Radioactive releases from the nuclear power sector and implications for child health.BMJ paediatrics open · 2022Review
- Review of Knowledge of Uranium-Induced Kidney Toxicity for the Development of an Adverse Outcome Pathway to Renal Impairment.International journal of molecular sciences · 2022Review
- Spatial relationship between well water arsenic and uranium in Northern Plains native lands.Environmental pollution (Barking, Essex : 1987) · 2021Article
- Modulation of PARP activity by Monomethylarsonous (MMAToxicology and applied pharmacology · 2021Article
- Uranium directly interacts with the DNA repair protein poly (ADP-ribose) polymerase 1.Toxicology and applied pharmacology · 2021Article
- Differential response of human T-lymphocytes to arsenic and uranium.Toxicology letters · 2020Article
- Uranium in drinking water: a public health threat.Archives of toxicology · 2020Review
- Elevated autoimmunity in residents living near abandoned uranium mine sites on the Navajo Nation.Journal of autoimmunity · 2019Article
- Uranyl acetate induced DNA single strand breaks and AP sites in Chinese hamster ovary cells.Toxicology and applied pharmacology · 2018Article
- Inhibitory effect of uranyl nitrate on DNA double-strand break repair by depression of a set of proteins in the homologous recombination pathway.Toxicology research · 2017Article
- PARP-1 overexpression contributes to Cadmium-induced death in rat proximal tubular cells via parthanatos and the MAPK signalling pathway.Scientific reports · 2017Article
- Mining and Environmental Health Disparities in Native American Communities.Current environmental health reports · 2017Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Uranium has radiological and non-radiological effects within biological systems and there is increasing evidence for genotoxic and carcinogenic properties attributable to uranium through its heavy metal properties. In this study, we report that low concentrations of uranium (as uranyl acetate; <10 μM) is not cytotoxic to human embryonic kidney cells or normal human keratinocytes; however, uranium exacerbates DNA damage and cytotoxicity induced by hydrogen peroxide, suggesting that uranium may inhibit DNA repair processes. Concentrations of uranyl acetate in the low micromolar range inhibited the zinc finger DNA repair protein poly(ADP-ribose) polymerase (PARP)-1 and caused zinc loss from PARP-1 protein. Uranyl acetate exposure also led to zinc loss from the zinc finger DNA repair proteins Xeroderma Pigmentosum, Complementation Group A (XPA) and aprataxin (APTX). In keeping with the observed inhibition of zinc finger function of DNA repair proteins, exposure to uranyl acetate enhanced retention of induced DNA damage. Co-incubation of uranyl acetate with zinc largely overcame the impact of uranium on PARP-1 activity and DNA damage. These findings present evidence that low concentrations of uranium can inhibit DNA repair through disruption of zinc finger domains of specific target DNA repair proteins. This may provide a mechanistic basis to account for the published observations that uranium exposure is associated with DNA repair deficiency in exposed human populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.