ArticleBiosensors & bioelectronics2017
Quantifying the effect of ionic screening with protein-decorated graphene transistors.
Article in Biosensors & bioelectronics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Engineering two-dimensional electronic biosensors.Nature reviews electrical engineering · 2026Article
- From Sensing Mechanisms to System Co-Design: Graphene-Based Sensors and Readout Circuits.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- The Application of Flexible Graphene Field-Effect Transistor Sensors in Multidimensional Biosensing and Precision Medicine.Materials (Basel, Switzerland) · 2026Review
- Intracellular sensing with transparent graphene-nanotube electrodes.2d materials · 2026Article
- Recent Advances in Graphene-Based Field-Effect Transistor Biosensors for Disease Biomarker Detection and Clinical Prospects.Biosensors · 2026Review
- An immobilized antibody-based affinity grid strategy for on-grid purification of target proteins enables high-resolution cryo-EM.Communications biology · 2024Article
- Graphene oxide-graphene Van der Waals heterostructure transistor biosensor for SARS-CoV-2 protein detection.Talanta · 2022Article
- Biomarkers and Detection Platforms for Human Health and Performance Monitoring: A Review.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Review
- Influence of the Electrolyte Salt Concentration on DNA Detection with Graphene Transistors.Biosensors · 2021Article
- Graphene-family materials in electrochemical aptasensors.Analytical and bioanalytical chemistry · 2021Review
- Molecular recognition with soft biomaterials.Soft matter · 2020Article
- Water Soluble G-protein Coupled Receptor Enabled Biosensors.Translational perioperative and pain medicine · 2019Article
- Detection of Sub-fM DNA with Target Recycling and Self-Assembly Amplification on Graphene Field-Effect Biosensors.Nano letters · 2018Article
- All-Electronic Quantification of Neuropeptide-Receptor Interaction Using a Bias-Free Functionalized Graphene Microelectrode.ACS nano · 2018Article
- pH Sensing Properties of Flexible, Bias-Free Graphene Microelectrodes in Complex Fluids: From Phosphate Buffer Solution to Human Serum.Small (Weinheim an der Bergstrasse, Germany) · 2017Article
- Scalable Production of High-Sensitivity, Label-Free DNA Biosensors Based on Back-Gated Graphene Field Effect Transistors.ACS nano · 2016Article
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Authors and funding
5 authors.
Funding
Abstract
Liquid-based applications of biomolecule-decorated field-effect transistors (FETs) range from biosensors to in vivo implants. A critical scientific challenge is to develop a quantitative understanding of the gating effect of charged biomolecules in ionic solution and how this influences the readout of the FETs. To address this issue, we fabricated protein-decorated graphene FETs and measured their electrical properties, specifically the shift in Dirac voltage, in solutions of varying ionic strength. We found excellent quantitative agreement with a model that accounts for both the graphene polarization charge and ionic screening of ions adsorbed on the graphene as well as charged amino acids associated with the immobilized protein. The technique and analysis presented here directly couple the charging status of bound biomolecules to readout of liquid-phase FETs fabricated with graphene or other two-dimensional materials.
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Registered trials
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