ArticleBMC psychiatry2015
Neurometabolic characteristics in the anterior cingulate gyrus of Alzheimer's disease patients with depression: a (1)H magnetic resonance spectroscopy study.
Article in BMC psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 24 citations in OpenAlex.
- Regional and aging-specific cellular architecture of non-human primate brains.Genome medicine · 2025Article
- Cortical signature of depressive symptoms in frontotemporal dementia: A surface-based analysis.Annals of clinical and translational neurology · 2023Article
- Characterization of Depressive Symptoms in Dementia and Examination of Possible Risk Factors.Journal of Alzheimer's disease reports · 2023Article
- Uncovering the System Vulnerability and Criticality of Human Brain Under Dynamical Neuropathological Events in Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2023Article
- Persistent depressive symptoms are associated with frontal regional atrophy in patients with Alzheimer's disease.International journal of geriatric psychiatry · 2023Article
- Synthesis, Characterization and Biological Evaluation of Benzothiazole-Isoquinoline Derivative.Molecules (Basel, Switzerland) · 2022Article
- Chronic Anxiety- and Depression-Like Behaviors Are Associated With Glial-Driven Pathology Following Repeated Blast Induced Neurotrauma.Frontiers in behavioral neuroscience · 2021Article
- Article
- Quantitation of in vivo brain glutathione conformers in cingulate cortex among age-matched control, MCI, and AD patients using MEGA-PRESS.Human brain mapping · 2020Article
- Abnormal changes in functional connectivity between the amygdala and frontal regions are associated with depression in Alzheimer's disease.Neuroradiology · 2018Article
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDepression is a common comorbid psychiatric symptom in patients with Alzheimer's disease (AD), and the prevalence of depression is higher among people with AD compared with healthy older adults. Comorbid depression in AD may increase the risk of cognitive decline, impair patients' function, and reduce their quality of life. However, the mechanisms of depression in AD remain unclear. Here, our aim was to identify neurometabolic characteristics in the brain that are associated with depression in patients with mild AD.
methodsThirty-seven patients were evaluated using the Neuropsychiatric Inventory (NPI) and Hamilton Depression Rating Scale (HAMD-17), and divided into two groups: 17 AD patients with depression (D-AD) and 20 non-depressed AD patients (nD-AD). Using proton magnetic resonance spectroscopy, we characterized neurometabolites in the anterior cingulate gyrus (ACG) of D-AD and nD-AD patients.
resultsCompared with nD-AD patients, D-AD patients showed lower N-acetylaspartate/creatine (NAA/Cr) and higher myo-inositol/creatine (mI/Cr) in the left ACG. NPI score correlated with NAA/Cr and mI/Cr in the left ACG, while HAMD correlated with NAA/Cr.
conclusionsOur findings show neurometabolic alterations in D-AD patients. Thus, D-AD pathogenesis may be attributed to abnormal activity of neurons and glial cells in the left ACG.
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