Evidence map›Paper›PMID 26626624›Full record

SynthesisAmerican journal of human genetics2015

Genome-wide Association Analysis of Psoriatic Arthritis and Cutaneous Psoriasis Reveals Differences in Their Genetic Architecture.

Philip E Stuart, Rajan P Nair, Lam C Tsoi, Trilokraj Tejasvi, Sayantan Das, Hyun Min Kang, Eva Ellinghaus, Vinod Chandran, Kristina Callis-Duffin, Robert Ike and 30 more

Open access · bronzeAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in American journal of human genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 166 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
166citing papers in PubMed, 11 pooled it
12.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

166 citing papers in PubMed, 11 syntheses or guidelines pooled it, 317 citations in OpenAlex.

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  16. Medicina (Kaunas, Lithuania) · 2026
    Observational
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106 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

40 authors at 20 institutions in 6 countries.

Philip E StuartDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Rajan P NairDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Lam C TsoiDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.
Trilokraj TejasviDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Ann Arbor Veterans Affairs Hospital, Ann Arbor, MI 48105, USA.
Sayantan DasDepartment of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA.
Hyun Min KangDepartment of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA.
Eva EllinghausInstitute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, 24105 Kiel, Germany.
Vinod ChandranDepartment of Medicine, Division of Rheumatology, University of Toronto, Toronto, ON M5T 2S8, Canada; Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Research Institute, University of Toronto, Toronto, ON M5T 2S8, Canada.
Kristina Callis-DuffinDepartment of Dermatology, University of Utah, Salt Lake City, UT 84132, USA.
Robert IkeDepartment of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Yanming LiDepartment of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA.
Xiaoquan WenDepartment of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA.
Charlotta EnerbäckDepartment of Clinical and Experimental Medicine, Division of Cell Biology and Dermatology, Linköping University, 581 83 Linköping, Sweden.
Johann E GudjonssonDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Sulev KõksDepartment of Pathophysiology, Centre of Translational Medicine and Centre for Translational Genomics, University of Tartu, 50411 Tartu, Estonia; Department of Reproductive Biology, Estonian University of Life Sciences, 51014 Tartu, Estonia.
Külli KingoDermatology Clinic, Tartu University Hospital, Department of Dermatology and Venereology, University of Tartu, 50417 Tartu, Estonia.
Tõnu EskoEstonian Genome Center, University of Tartu, 51010 Tartu, Estonia.
Ulrich MrowietzDepartment of Dermatology, University Medical Center Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany.
Andre ReisInstitute of Human Genetics, University of Erlangen-Nuremberg, 91054 Erlangen, Germany.
H Erich WichmannInstitute of Epidemiology I, Helmholtz Zentrum Munich, German Research Center for Environmental Health, 85764 Neuherberg, Germany; Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-University, 81377 Munich, Germany; Institute of Medical Statistics and Epidemiology, Technical University Munich, 80333 Munich, Germany.
Christian GiegerResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Per HoffmannInstitute of Human Genetics, University of Bonn, 53127 Bonn, Germany; Department of Genomics, Life & Brain Center, University of Bonn, 53127 Bonn, Germany.
Markus M NöthenInstitute of Human Genetics, University of Bonn, 53127 Bonn, Germany; Department of Genomics, Life & Brain Center, University of Bonn, 53127 Bonn, Germany.
Juliane WinkelmannNeurologische Klinik and Poliklinik, Klinikum rechts der Isar, Technische Universität München, 80333 Munich, Germany; Institute of Neurogenomics, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Manfred KunzDepartment of Dermatology, Venereology and Allergology, University of Leipzig, 04103 Leipzig, Germany.
Elvia G MoretaSaint Paul Rheumatology, Eagan, MN 55121, USA.
Philip J MeaseSeattle Rheumatology Associates, 601 Broadway, Suite 600, Seattle, WA 98122, USA.
Christopher T RitchlinAllergy, Immunology, and Rheumatology Division, University of Rochester Medical Center, Rochester, NY 14623, USA.
Anne M BowcockNational Heart and Lung Institute, Imperial College, London SW7 2AZ, UK.
Gerald G KruegerDepartment of Dermatology, University of Utah, Salt Lake City, UT 84132, USA.
Henry W LimDepartment of Dermatology, Henry Ford Hospital, Detroit, MI 48202, USA.
Stephan WeidingerDepartment of Dermatology, University Medical Center Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany.
Michael WeichenthalDepartment of Dermatology, University Medical Center Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany.
John J VoorheesDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Proton RahmanMemorial University, St. John's, NL A1C 5B8, Canada.
Peter K GregersenThe Feinstein Institute for Medical Research, North Shore-Long Island Jewish Health System, Manhasset, NY 11030, USA.
Andre FrankeInstitute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, 24105 Kiel, Germany.
Dafna D GladmanDepartment of Medicine, Division of Rheumatology, University of Toronto, Toronto, ON M5T 2S8, Canada; Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Research Institute, University of Toronto, Toronto, ON M5T 2S8, Canada.
Gonçalo R AbecasisDepartment of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA.
James T ElderDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Ann Arbor Veterans Affairs Hospital, Ann Arbor, MI 48105, USA. Electronic address: jelder@umich.edu.
University of Michigan–Ann Arbor · USKiel University · DELife & Brain (Germany) · DERheumatology Consultants · USUniversity of Utah · USEstonian University of Life Sciences · EEFeinstein Institute for Medical Research · USFriedrich-Alexander-Universität Erlangen-Nürnberg · DEHelmholtz Zentrum München · DEHenry Ford Hospital · USImperial College London · GBKlinikum rechts der Isar · DELeipzig University · DELinköping University · SEMemorial University of Newfoundland · CATartu University Hospital · EEToronto Western Hospital · CAUniversity of Rochester Medical Center · USUniversity of Tartu · EEUniversity of Toronto · CA

Funding

ZINC GLUCONATE GLYCINE LOZENGES &VITAMIN C EFFECTS ON COMMON COLDM01RR000042 · NCRR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELSTROM, REBECCA L · 1985 to 2007
$40.8M
Linkage analysis of familial psoriasis(Supplement)R01AR042742 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELDER, JAMES TILFORD · 1994 to 2021
$10.1M
Genetic and Genomic Dissection of Psoriatic ArthritisR01AR063611 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELDER, JAMES TILFORD, GLADMAN, DAFNA D · 2012 to 2023
$6.2M
Genome-Wide SNP Association in PsoriasisR01AR050266 · NIAMS · WASHINGTON UNIVERSITY · PI BOWCOCK, ANNE MARY · 2007 to 2016
$5.7M
Identification of Psoriatic Arthritis Genes in the MHCR01AR050511 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELDER, JAMES TILFORD · 2004 to 2013
$4.2M
Combined Analysis of Gene Expression and DNA Variation in PsoriasisR01AR054966 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELDER, JAMES TILFORD · 2007 to 2011
$3.2M
Functional Genomics of PsoriasisR01AR065183 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELDER, JAMES TILFORD · 2013 to 2016
$1.7M
Role of the Psoriasis Associated IL23R Risk Variants on Th17 Biology and FunctionK08AR060802 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GUDJONSSON, JOHANN ELI · 2011 to 2015
$636k
NCRR NIH HHS M01 RR000042NIAMS NIH HHS K08 AR060802NIAMS NIH HHS R01 AR042742NIAMS NIH HHS R01AR042742NIAMS NIH HHS R01 AR050266NIAMS NIH HHS R01AR050266NIAMS NIH HHS R01 AR050511NIAMS NIH HHS R01AR050511NIAMS NIH HHS R01 AR054966NIAMS NIH HHS R01AR054966NIAMS NIH HHS R01 AR063611NIAMS NIH HHS R01AR063611NIAMS NIH HHS R01 AR065183NIAMS NIH HHS R01AR065183
6 · The paper itself

Abstract

Psoriasis vulgaris (PsV) is a common inflammatory and hyperproliferative skin disease. Up to 30% of people with PsV eventually develop psoriatic arthritis (PsA), an inflammatory musculoskeletal condition. To discern differences in genetic risk factors for PsA and cutaneous-only psoriasis (PsC), we carried out a genome-wide association study (GWAS) of 1,430 PsA case subjects and 1,417 unaffected control subjects. Meta-analysis of this study with three other GWASs and two targeted genotyping studies, encompassing a total of 9,293 PsV case subjects, 3,061 PsA case subjects, 3,110 PsC case subjects, and 13,670 unaffected control subjects of European descent, detected 10 regions associated with PsA and 11 with PsC at genome-wide (GW) significance. Several of these association signals (IFNLR1, IFIH1, NFKBIA for PsA; TNFRSF9, LCE3C/B, TRAF3IP2, IL23A, NFKBIA for PsC) have not previously achieved GW significance. After replication, we also identified a PsV-associated SNP near CDKAL1 (rs4712528, odds ratio [OR] = 1.16, p = 8.4 × 10(-11)). Among identified psoriasis risk variants, three were more strongly associated with PsC than PsA (rs12189871 near HLA-C, p = 5.0 × 10(-19); rs4908742 near TNFRSF9, p = 0.00020; rs10888503 near LCE3A, p = 0.0014), and two were more strongly associated with PsA than PsC (rs12044149 near IL23R, p = 0.00018; rs9321623 near TNFAIP3, p = 0.00022). The PsA-specific variants were independent of previously identified psoriasis variants near IL23R and TNFAIP3. We also found multiple independent susceptibility variants in the IL12B, NOS2, and IFIH1 regions. These results provide insights into the pathogenetic similarities and differences between PsC and PsA.

Indexed as

Genetic LociGenetic Predisposition to DiseasePolymorphism, Single NucleotideAdolescentAdultArthritis, PsoriaticBayes TheoremCase-Control StudiesCornified Envelope Proline-Rich ProteinsDNA-Binding ProteinsFemaleGenome-Wide Association StudyHLA-C AntigensHumansIntracellular Signaling Peptides and ProteinsLinkage DisequilibriumCornified Envelope Proline-Rich ProteinsDNA-Binding ProteinsHLA-C AntigensIL23R protein, humanIntracellular Signaling Peptides and ProteinsNuclear ProteinsReceptors, InterleukinTNFAIP3 protein, humanTNFRSF9 protein, humanTumor Necrosis Factor alpha-Induced Protein 3Tumor Necrosis Factor Receptor Superfamily, Member 9genome-wide association studyjoint diseasespsoriasispsoriatic arthritisskin diseases

Identifiers

PMID26626624
PMCPMC4678416
OpenAlexW2176753380

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.