Evidence map›Paper›PMID 26626596›Full record

ReviewTrends in parasitology2016

Mosquito Defense Strategies against Viral Infection.

Gong Cheng, Yang Liu, Penghua Wang, Xiaoping Xiao

Abstract readReview
In one paragraph

Review in Trends in parasitology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 129 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
129citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

129 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Transovarial transmission of mosquito-borne viruses: a systematic review.Frontiers in cellular and infection microbiology · 2023
    Pooled it
  2. A gut commensalVirulence · 2026
    Article
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  17. West Nile virus unmasked: from gene variability to future challenges.Frontiers in cellular and infection microbiology · 2025
    Review
  18. Article
  19. Article
  20. Article

69 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Gong ChengCollaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, School of Medicine, Tsinghua University, Beijing 100084, PR China. Electronic address: gongcheng@mail.tsinghua.edu.cn.
Yang LiuCollaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, School of Medicine, Tsinghua University, Beijing 100084, PR China; School of Life Science, Tsinghua University, Beijing 100084, PR China.
Penghua WangDepartment of Microbiology and Immunology, School of Medicine, New York Medical College, Valhalla, NY 10595, USA.
Xiaoping XiaoCollaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, School of Medicine, Tsinghua University, Beijing 100084, PR China.

Funding

A critical role of NLRP6 in West Nile virus pathogenesis in miceR21AI103807 · NIAID · YALE UNIVERSITY · PI WANG, PENGHUA · 2014 to 2015
$438k
The role of interleukin 22 in West Nile virus pathogenesis in miceR03AI099625 · NIAID · YALE UNIVERSITY · PI WANG, PENGHUA · 2013 to 2014
$166k
NIAID NIH HHS AI099625NIAID NIH HHS AI103807NIAID NIH HHS R03 AI099625NIAID NIH HHS R21 AI103807
6 · The paper itself

Abstract

Mosquito-borne viral diseases are a major concern of global health and result in significant economic losses in many countries. As natural vectors, mosquitoes are very permissive to and allow systemic and persistent arbovirus infection. Intriguingly, persistent viral propagation in mosquito tissues neither results in dramatic pathological sequelae nor impairs the vectorial behavior or lifespan, indicating that mosquitoes have evolved mechanisms to tolerate persistent infection and developed efficient antiviral strategies to restrict viral replication to nonpathogenic levels. Here we provide an overview of recent progress in understanding mosquito antiviral immunity and advances in the strategies by which mosquitoes control viral infection in specific tissues.

Indexed as

AnimalsArbovirusesCulicidaeHemolymphNeuronsRNA InterferenceSalivary GlandsVirus Replicationantiviral immunityarbovirusmosquito

Identifiers

PMID26626596
PMCPMC4767563

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.