ArticleLipids2016
Reduced Maternal Erythrocyte Long Chain Polyunsaturated Fatty Acids Exist in Early Pregnancy in Preeclampsia.
Article in Lipids, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- Multidimensional Plasma Lipids Affect Preeclampsia/Eclampsia: A Mendelian Randomization Study.Journal of clinical hypertension (Greenwich, Conn.) · 2025Article
- Identification of causal candidates for pregnancy-induced hypertension through Bayesian model averaging-based Mendelian randomization.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- BMA-based Mendelian randomization identifies blood metabolites as causal candidates in pregnancy-induced hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- The causal role of intestinal microbiome in development of pre-eclampsia.Functional & integrative genomics · 2023Article
- Comprehensive fatty acid fractionation profilling in preeclampsia: a case control study with multivariable analysis.BMC pregnancy and childbirth · 2022Article
- Gestational weight gain in the REVAMP pregnancy cohort in Western India: Comparison with international and national references.Frontiers in medicine · 2022Article
- The association between dietary fatty acid intake and the risk of developing preeclampsia: a matched case-control study.Scientific reports · 2021Article
- Association of preeclampsia with anthropometric measures and blood pressure in Indian children.PloS one · 2020Article
- The REVAMP study: research exploring various aspects and mechanisms in preeclampsia: study protocol.BMC pregnancy and childbirth · 2019Article
- Lasting Effects of Intrauterine Exposure to Preeclampsia on Offspring and the Underlying Mechanism.AJP reports · 2019Review
- Low omega-3 index values and monounsaturated fatty acid levels in early pregnancy: an analysis of maternal erythrocytes fatty acids.Lipids in health and disease · 2018Article
- Is phosphatidylglycerol essential for terrestrial life?Journal of chemical biology · 2017Review
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present prospective study examines proportions of maternal erythrocyte fatty acids across gestation and their association with cord erythrocyte fatty acids in normotensive control (NC) and preeclamptic pregnancies. We hypothesize that maternal fatty acid status in early pregnancy influences fetal fatty acid stores in preeclampsia. 137 NC women and 58 women with preeclampsia were included in this study. Maternal blood was collected at 3 time points during pregnancy (16-20th weeks, 26-30th weeks and at delivery). Cord blood was collected at delivery. Fatty acids were analyzed using gas chromatography. The proportions of maternal erythrocyte α-linolenic acid, docosahexaenoic acid, nervonic acid, and monounsaturated fatty acids (MUFA) (p < 0.05 for all) were lower while total n-6 fatty acids were higher (p < 0.05) at 16-20th weeks of gestation in preeclampsia as compared with NC. Cord 18:3n-3, 22:6n-3, 24:1n-9, MUFA, and total n-3 fatty acids (p < 0.05 for all) were also lower in preeclampsia as compared with NC. A positive association was observed between maternal erythrocyte 22:6n-3 and 24:1n-9 at 16-20th weeks with the same fatty acids in cord erythrocytes (p < 0.05 for both) in preeclampsia. Our study for the first time indicates alteration in maternal erythrocyte fatty acids at 16th weeks of gestation which is further reflected in cord erythrocytes at delivery in preeclampsia.
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