ArticleParasites & vectors2015
Presence of the knockdown resistance mutation, Vgsc-1014F in Anopheles gambiae and An. arabiensis in western Kenya.
Article in Parasites & vectors, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34 citing papers in PubMed.
- Genomic Connectivity and Adaptive Gene Flow ofResearch square · 2026Article
- Structural features of outdoor latrines influence the abundance of Anopheles gambiae s.l. and Culex quinquefasciatus in a village in Kisumu County, western Kenya.Parasites & vectors · 2025Article
- Insecticide resistance intensity inCurrent research in parasitology & vector-borne diseases · 2025Article
- Assessing agricultural practices and insecticides resistance for effective malaria vector control in northwestern Iran.Tropical medicine and health · 2024Article
- Key gene modules and hub genes associated with pyrethroid and organophosphate resistance in Anopheles mosquitoes: a systems biology approach.BMC genomics · 2024Article
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- Species composition and insecticide resistance in malaria vectors in Ellibou, southern Côte d'Ivoire and first finding of Anopheles arabiensis in Côte d'Ivoire.Malaria journal · 2023Article
- Widespread occurrence of copy number variants and fixation of pyrethroid target site resistance inCurrent research in parasitology & vector-borne diseases · 2023Article
- Molecular Drivers of Multiple and Elevated Resistance to Insecticides in a Population of the Malaria VectorGenes · 2022Article
- Composition of mosquito fauna and insecticide resistance status of Anopheles gambiae sensu lato in Itang special district, Gambella, Southwestern Ethiopia.Malaria journal · 2022Article
- Resistance ofAfrican health sciences · 2022Article
- Genetic markers associated with insecticide resistance and resting behaviour in Anopheles gambiae mosquitoes in selected sites in Kenya.Malaria journal · 2021Article
- First report of the L1014F kdr mutation in wild populations of Anopheles arabiensis in Cabo Verde, West Africa.Parasites & vectors · 2021Article
- Insecticide resistance status of Anopheles arabiensis in irrigated and non-irrigated areas in western Kenya.Parasites & vectors · 2021Article
- Secondary malaria vectors in western Kenya include novel species with unexpectedly high densities and parasite infection rates.Parasites & vectors · 2021Article
- Western Kenyan Anopheles gambiae showing intense permethrin resistance harbour distinct microbiota.Malaria journal · 2021Article
- Insecticide resistance status of indoor and outdoor resting malaria vectors in a highland and lowland site in Western Kenya.PloS one · 2021Article
- Phenotypic, genotypic and biochemical changes during pyrethroid resistance selection in Anopheles gambiae mosquitoes.Scientific reports · 2020Article
- Article
- Impact of indoor residual spraying with pirimiphos-methyl (Actellic 300CS) on entomological indicators of transmission and malaria case burden in Migori County, western Kenya.Scientific reports · 2020Article
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12 authors.
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Abstract
introductionThe voltage gated sodium channel mutation Vgsc-1014S (kdr-east) was first reported in Kenya in 2000 and has since been observed to occur at high frequencies in the local Anopheles gambiae s.s. POPULATION: The mutation Vgsc-1014F has never been reported from An. gambiae Complex complex mosquitoes in Kenya.
findingsMolecularly confirmed An. gambiae s.s. (hereafter An. gambiae) and An. arabiensis collected from 4 different parts of western Kenya were genotyped for kdr from 2011 to 2013. Vgsc-1014F was observed to have emerged, apparently, simultaneously in both An. gambiae and An. arabiensis in 2012. A portion of the samples were submitted for sequencing in order to confirm the Vgsc-1014F genotyping results. The resulting sequence data were deposited in GenBank (Accession numbers: KR867642-KR867651, KT758295-KT758303). A single Vgsc-1014F haplotype was observed suggesting, a common origin in both species.
conclusionThis is the first report of Vgsc-1014F in Kenya. Based on our samples, the mutation is present in low frequencies in both An. gambiae and An. arabiensis. It is important that we start monitoring relative frequencies of the two kdr genes so that we can determine their relative importance in an area of high insecticide treated net ownership.
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