Evidence map›Paper›PMID 26626214›Full record

ArticleThe Journal of urology2016

Intraoperative Optical Biopsy during Robotic Assisted Radical Prostatectomy Using Confocal Endomicroscopy.

Aristeo Lopez, Dimitar V Zlatev, Kathleen E Mach, Daniel Bui, Jen-Jane Liu, Robert V Rouse, Theodore Harris, John T Leppert, Joseph C Liao

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In one paragraph

Article in The Journal of urology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  18. Fluorescence Image-Guided Surgery - a Perspective on Contrast Agent Development.Proceedings of SPIE--the International Society for Optical Engineering · 2020
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Aristeo Lopez *Department of Urology, Stanford University School of Medicine, Stanford, CA 94305-5118.
Dimitar V Zlatev *Department of Urology, Stanford University School of Medicine, Stanford, CA 94305-5118.
Kathleen E MachDepartment of Urology, Stanford University School of Medicine, Stanford, CA 94305-5118.
Daniel BuiDepartment of Urology, Stanford University School of Medicine, Stanford, CA 94305-5118.
Jen-Jane LiuDepartment of Urology, Stanford University School of Medicine, Stanford, CA 94305-5118.
Robert V RouseVeterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304.
Theodore HarrisVeterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304.
John T LeppertDepartment of Urology, Stanford University School of Medicine, Stanford, CA 94305-5118.
Joseph C LiaoDepartment of Urology, Stanford University School of Medicine, Stanford, CA 94305-5118.

Funding

Optical Imaging of Bladder Cancer with Molecular Contrast AgentsR01CA160986 · NCI · STANFORD UNIVERSITY · PI LIAO, JOSEPH C · 2011 to 2014
$1.7M
NCI NIH HHS R01 CA160986
6 · The paper itself

Abstract

purposeIntraoperative optical biopsy technologies may aid in the identification of important anatomical landmarks and improve surgical outcomes of robotic assisted radical prostatectomy. We evaluate the feasibility of confocal laser endomicroscopy during robotic assisted radical prostatectomy. MATERIALS AND

methodsA total of 21 patients with biopsy proven prostate cancer scheduled for robotic assisted radical prostatectomy were recruited. After intravenous administration of fluorescein 15 patients underwent in vivo intraoperative confocal laser endomicroscopy of prostatic and periprostatic structures using a 2.6 or 0.85 mm imaging probe. Standard robotic instruments were used to grasp and maneuver the confocal laser endomicroscopy probes for image acquisition. Confocal laser endomicroscopy imaging was performed ex vivo on fresh prostate specimens from 20 patients. Confocal video sequences acquired in vivo and ex vivo were reviewed and analyzed, with additional image processing using a mosaicing algorithm. Processed confocal images were compared with standard hematoxylin and eosin analysis of imaged regions.

resultsConfocal laser endomicroscopy was successfully integrated with robotic surgery, including co-registration of confocal video sequences with white light and probe handling with standard robotic instrumentation. Intraoperative confocal laser endomicroscopy imaging of the neurovascular bundle before and after nerve sparing dissection revealed characteristic features including dynamic vascular flow and intact axon fibers. Ex vivo confocal imaging of the prostatic parenchyma demonstrated normal prostate glands, stroma and prostatic carcinoma.

conclusionsWe report the initial feasibility of optical biopsy of prostatic and periprostatic tissue during robotic assisted radical prostatectomy. Image guidance and tissue interrogation using confocal laser endomicroscopy offer a new intraoperative imaging method that has the potential to improve the functional and oncologic outcomes of prostate cancer surgery.

Indexed as

AgedBiopsyFeasibility StudiesHumansMaleMicroscopy, ConfocalMiddle AgedProstateProstatectomyProstatic NeoplasmsRobotic Surgical Procedureserectile dysfunctionmicroscopy, confocalprostatectomyprostatic neoplasmssurgery, computer-assisted

Identifiers

PMID26626214
PMCPMC4882279

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.