SynthesisIntensive care medicine2016
Health-related quality-of-life among survivors of acute kidney injury in the intensive care unit: a systematic review.
Synthesis in Intensive care medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 3 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- European Society of Intensive Care Medicine Clinical Practice Guideline on fluid therapy in adult critically ill patients: Part 3-fluid removal at de-escalation phase.Intensive care medicine · 2025Guideline
- Health-Related Quality of Life of Adult Sepsis Survivors Following Critical Illness: A Systematic Review.Critical care explorations · 2025Pooled it
- Acute kidney injury in trauma patients admitted to the ICU: a systematic review and meta-analysis.Intensive care medicine · 2019Pooled it
- Social Determinants of Health and ESKD among Survivors of Critical Illness and Acute Kidney Injury.Clinical journal of the American Society of Nephrology : CJASN · 2026Observational
- Proenkephalin A for assessing kidney integrity and guiding KRT liberation decisions in critically ill patients.Annals of intensive care · 2026Article
- Economic burden of acute kidney injury in children and adults: a protocol for a systematic review and meta-analysis.BMJ open · 2024Article
- Tumour lysis syndrome.Nature reviews. Disease primers · 2024Review
- Long-Term Mortality and Health-Related Quality of Life After Continuous Versus Intermittent Renal Replacement Therapy in ICU Survivors: A Secondary Analysis of the Quality of Life After ICU Study.Journal of intensive care medicine · 2024Article
- Is comorbidity alone responsible for changes in health-related quality of life among critical care survivors? A purpose-specific review.Critical care (London, England) · 2024Review
- Sepsis-associated acute kidney injury: recent advances in enrichment strategies, sub-phenotyping and clinical trials.Critical care (London, England) · 2024Review
- Accurate and interpretable prediction of ICU-acquired AKI.Journal of critical care · 2023Article
- Survive or thrive after ICU: what's the score?Annals of intensive care · 2023Article
- Endocrinological disorders in acute kidney injury: an often overlooked field of clinical research.Journal of nephrology · 2023Review
- Long-term outcomes after severe acute kidney injury in critically ill patients: the SALTO study.Annals of intensive care · 2023Article
- Suppression of NRF2 Activity by HIF-1α Promotes Fibrosis after Ischemic Acute Kidney Injury.Antioxidants (Basel, Switzerland) · 2022Article
- Article
- Development and Feasibility of a Multidisciplinary Approach to AKI Survivorship in Care Transitions: Research Letter.Canadian journal of kidney health and disease · 2022Article
- Relationship between uric acid and kidney function in adults at risk for tumor lysis syndrome.Leukemia & lymphoma · 2021Article
- Acute kidney injury.Nature reviews. Disease primers · 2021Review
- Differences in Health-Related Quality of Life Among Adults with a Potential Dihydropyridine Calcium Channel Blocker-Loop Diuretic Prescribing Cascade.Drugs & aging · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo summarize evidence on long-term health-related quality-of-life (HRQL) among survivors of acute kidney injury (AKI) in the intensive care unit (ICU).
methodsWe performed a comprehensive search of the literature for studies reporting original data describing HRQL utilizing validated instruments. Search, study selection and data abstraction were performed in duplicate. Study quality was appraised. Due to study heterogeneity, data are primarily summarized qualitatively.
resultsOur search yielded 2193 articles of which 18 were selected for detailed analysis. The quality of these 18 studies was generally good. Numerous HRQL instruments were utilized, and assessment occurred at variable follow-up duration (range 2 months to 14.5 years). HRQL among AKI survivors was reduced when compared to age/sex-matched populations. HRQL among survivors with and without AKI was generally described as similar beyond 6 months. Physical component domains were consistently more impaired than mental component domains. Survivors had considerable limitations in activities of daily living, implying newly acquired disability, with few returning to work. Despite diminished HRQL, patients' HRQL was generally perceived as satisfactory, and the majority would receive similar treatment again, including renal replacement therapy in the ICU, if necessary.
conclusionsAmong survivors of critical illness complicated by AKI, HRQL was impaired when referenced to population norms, but it was not significantly different from that of survivors without AKI. Physical limitations and disabilities were more commonly exhibited by AKI patients. Importantly, the impaired HRQL was generally perceived as acceptable to patients, most of whom expressed willingness to undergo similar treatment in the future.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.