Evidence map›Paper›PMID 26625873›Full record

ReviewNeuroscience bulletin2015

Experimental animal models and inflammatory cellular changes in cerebral ischemic and hemorrhagic stroke.

Tao Yan, Michael Chopp, Jieli Chen

Open access · greenAbstract readReview
In one paragraph

Review in Neuroscience bulletin, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 59 citations in OpenAlex.

  1. Article
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  17. Review
  18. International journal of medical sciences · 2021
    Article
  19. Mitochondrial BKFrontiers in physiology · 2021
    Article
  20. The role of exosomes in stroke.Molecular biology reports · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Tao YanTianjin Neurological Institute, Department of Neurology, Tianjin Medical University General Hospital, Tianjin, 300052, China. jieli@neuro.hfh.edu.
Michael ChoppDepartment of Neurology, Henry Ford Hospital, Detroit, MI, 48202, USA.
Jieli ChenDepartment of Neurology, Henry Ford Hospital, Detroit, MI, 48202, USA. yantao78@hotmail.com.
Oakland University · US

Funding

Neurorestorative therapy of stroke with HUCBC in type two diabetic miceR01NS083078 · NINDS · HENRY FORD HEALTH SYSTEM · PI CHEN, JIELI · 2014 to 2018
$1.6M
miR-17-92 exosome treatment of strokeR01NS088656 · NINDS · HENRY FORD HEALTH SYSTEM · PI CHOPP, MICHAEL · 2015 to 2019
$1.6M
MSCs Induce Brain Plasticity via tPAR01AG037506 · NIA · HENRY FORD HEALTH SYSTEM · PI CHOPP, MICHAEL · 2011 to 2015
$1.5M
Neurorestorative therapy of stroke with agents that increase HDLR01AG031811 · NIA · HENRY FORD HEALTH SYSTEM · PI CHEN, JIELI · 2009 to 2013
$1.4M
Neurorestorative therapy of stroke with HUCBC in T2DM ratsR41NS080329 · NINDS · SANERON CCEL THERAPEUTICS, INC. · PI CHEN, JIELI · 2013 to 2014
$423k
NIA NIH HHS R01 AG031811NIA NIH HHS R01 AG037506NINDS NIH HHS R01 NS083078NINDS NIH HHS R01 NS083078-01A1NINDS NIH HHS R01 NS088656NINDS NIH HHS R41 NS080329NINDS NIH HHS R41 NS080329-01A1
6 · The paper itself

Abstract

Stroke, including cerebral ischemia, intracerebral hemorrhage, and subarachnoid hemorrhage, is the leading cause of long-term disability and death worldwide. Animal models have greatly contributed to our understanding of the risk factors and the pathophysiology of stroke, as well as the development of therapeutic strategies for its treatment. Further development and investigation of experimental models, however, are needed to elucidate the pathogenesis of stroke and to enhance and expand novel therapeutic targets. In this article, we provide an overview of the characteristics of commonly-used animal models of stroke and focus on the inflammatory responses to cerebral stroke, which may provide insights into a framework for developing effective therapies for stroke in humans.

Indexed as

Disease Models, AnimalAnimalsBrain IschemiaCerebral HemorrhageInflammationStrokeanimal modelhemorrhagic strokeinflammatory cellsischemic stroke

Identifiers

PMID26625873
PMCPMC4699577
OpenAlexW2220598573

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.