ReviewCurrent opinion in nephrology and hypertension2016
Cutaneous control of blood pressure.
Review in Current opinion in nephrology and hypertension, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 42 citations in OpenAlex.
- Novel Mechanism for Buffering Dietary Salt in Humans: Effects of Salt Loading on Skin Sodium, Vascular Endothelial Growth Factor C, and Blood Pressure.Hypertension (Dallas, Tex. : 1979) · 2017Trial
- The Influence of Sunscreen Use on Skin Pigmentation Disorders: Melasma, Post-Inflammatory Hyperpigmentation, and Vitiligo.Current issues in molecular biology · 2026Review
- Renin-Angiotensin-Aldosterone System in Preeclampsia: Pathophysiological Insights and Links to Vascular Dementia.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- Antagonizing IL-17A Reduces Vascular Inflammation and Attenuates Oxidative Stress Formation but Does Not Significantly Improve Vascular Dysfunction Induced by One Week of Angiotensin II Treatment.Antioxidants (Basel, Switzerland) · 2026Article
- Raman Investigation of Cardiac Tissues with Sodium-Induced High Stiffness.Molecules (Basel, Switzerland) · 2026Article
- Review
- Early reduction of skin potassium without sodium accumulation in the pathogenesis of salt sensitivity in primary aldosteronism.Frontiers in pharmacology · 2025Article
- Targeting Sodium in Heart Failure.Journal of personalized medicine · 2024Review
- Role of Lymphangiogenesis in Cardiac Repair and Regeneration.Methodist DeBakey cardiovascular journal · 2023Review
- Enhancement of Nitric Oxide Bioavailability by Modulation of Cutaneous Nitric Oxide Stores.Biomedicines · 2022Review
- Skin Sodium and Blood Pressure Regulation.Electrolyte & blood pressure : E & BP · 2022Review
- The first observation of osmotically neutral sodium accumulation in the myocardial interstitium.Scientific reports · 2021Article
- Adaptive physiological water conservation explains hypertension and muscle catabolism in experimental chronic renal failure.Acta physiologica (Oxford, England) · 2021Article
- The Effect of Whole-Body Cryostimulation in Healthy Adults : Whole-Body Cryostimulation According to Gender and Smoking Status.Advances in experimental medicine and biology · 2021Article
- Global warming, heat-related illnesses, and the dermatologist.International journal of women's dermatology · 2021Review
- Article
- New Insights on the Role of Sodium in the Physiological Regulation of Blood Pressure and Development of Hypertension.Frontiers in cardiovascular medicine · 2019Article
- Homeostasis in Topical Photoprotection: Getting the Spectral Balance Right.American journal of clinical dermatology · 2018Review
- Skin Sodium and Hypertension: a Paradigm Shift?Current hypertension reports · 2018Review
- Clocking skin sodium.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
Abstract
purpose of reviewTextbook theory holds that blood pressure (BP) is regulated by the brain, by blood vessels, or by the kidney. Recent evidence suggests that BP could be regulated in the skin. RECENT
findingsThe skin holds a complex capillary counter current system, which controls body temperature, skin perfusion, and apparently systemic BP. Epidemiological data suggest that sunlight exposure plays a role in controlling BP. Ultraviolet A radiation produces vasodilation and a fall in BP. Keratinocytes and immune cells control blood flow in the extensive countercurrent loop system of the skin by producing nitric oxide, a key regulator of vascular tone. The balance between hypoxia-inducible factor-1α and hypoxia-inducible factor-2α activity in keratinocytes controls skin perfusion, systemic thermoregulation, and systemic BP by nitric oxide-dependent mechanisms. Furthermore, the skin accumulates Na which generates a barrier to promote immunological host defense. Immune cells control skin Na metabolism and the clearance of Na via the lymphatic system. Reduced lymphatic clearance increases BP. SUMMARY: Apart from the well-known role of the brain, blood vessels, and the kidney, the skin is important for systemic BP control in humans and in experimental animals.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.