ArticleBMC pregnancy and childbirth2015
The Norwegian preeclampsia family cohort study: a new resource for investigating genetic aspects and heritability of preeclampsia and related phenotypes.
Article in BMC pregnancy and childbirth, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Development of a Triage Tool for Stratification and Referral of Women at Risk of Preeclampsia in Low-Resource Antenatal Settings: A Prospective Cohort Study.Health science reports · 2026Article
- No association of a Vascular endothelial growth factor A (VEGFA) gene polymorphism with pre-eclampsia among pregnant women in Uganda.BMC genomics · 2023Article
- Evaluation of epigenetic age calculators between preeclampsia and normotensive pregnancies in an Australian cohort.Scientific reports · 2022Observational
- Susceptibility to preeclampsia is associated with a 50-bp insertion/deletion polymorphism at the promoter region of theJournal of the Turkish German Gynecological Association · 2021Article
- A risk factor-based predictive model for new-onset hypertension during pregnancy in Chinese Han women.BMC cardiovascular disorders · 2020Article
- A Dormant Microbial Component in the Development of Preeclampsia.Frontiers in medicine · 2016Review
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Authors and funding
14 authors.
Funding
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Abstract
backgroundPreeclampsia is a major pregnancy complication without curative treatment available. A Norwegian Preeclampsia Family Cohort was established to provide a new resource for genetic and molecular studies aiming to improve the understanding of the complex pathophysiology of preeclampsia.
methodsParticipants were recruited from five Norwegian hospitals after diagnoses of preeclampsia registered in the Medical birth registry of Norway were verified according to the study's inclusion criteria. Detailed obstetric information and information on personal and family disease history focusing on cardiovascular health was collected. At attendance anthropometric measurements were registered and blood samples were drawn. The software package SPSS 19.0 for Windows was used to compute descriptive statistics such as mean and SD. P-values were computed based on t-test statistics for normally distributed variables. Nonparametrical methods (chi square) were used for categorical variables.
resultsA cohort consisting of 496 participants (355 females and 141 males) representing 137 families with increased occurrence of preeclampsia has been established, and blood samples are available for 477 participants. Descriptive analyses showed that about 60% of the index women's pregnancies with birth data registered were preeclamptic according to modern diagnosis criteria. We also found that about 41% of the index women experienced more than one preeclamptic pregnancy. In addition, the descriptive analyses confirmed that preeclamptic pregnancies are more often accompanied with delivery complications.
conclusionThe data and biological samples collected in this Norwegian Preeclampsia Family Cohort will provide an important basis for future research. Identification of preeclampsia susceptibility genes and new biomarkers may contribute to more efficient strategies to identify mothers "at risk" and contribute to development of novel preventative therapies.
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