ArticlePLoS pathogens2015
Functional Characterization of a Novel Class of Morantel-Sensitive Acetylcholine Receptors in Nematodes.
Article in PLoS pathogens, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- Reconstitution of an N-AChR from Brugia malayi, an evolved change in acetylcholine receptor accessory protein requirements in filarial parasites.PLoS pathogens · 2022Article
- The equine ascarids: resuscitating historic model organisms for modern purposes.Parasitology research · 2022Review
- Pharmacological characterization of novel heteromeric GluCl subtypes from Caenorhabditis elegans and parasitic nematodes.British journal of pharmacology · 2022Article
- Functional Characterization of the Oxantel-Sensitive Acetylcholine Receptor fromPharmaceuticals (Basel, Switzerland) · 2021Article
- Action of Carvacrol onPharmaceuticals (Basel, Switzerland) · 2021Article
- The molecular targets of ivermectin and lotilaner in the human louse Pediculus humanus humanus: New prospects for the treatment of pediculosis.PLoS pathogens · 2021Article
- The narrow-spectrum anthelmintic oxantel is a potent agonist of a novel acetylcholine receptor subtype in whipworms.PLoS pathogens · 2021Article
- Interaction of agonists of a different subtype of the nAChR and carvacrol with GABA inJournal of nematology · 2021Article
- Caenorhabditis elegans in anthelmintic research - Old model, new perspectives.International journal for parasitology. Drugs and drug resistance · 2020Review
- Plant-Based Natural Products for the Discovery and Development of Novel Anthelmintics against Nematodes.Biomolecules · 2020Review
- A Functional Comparison of Homopentameric Nicotinic Acetylcholine Receptors (ACR-16) Receptors FromFrontiers in molecular neuroscience · 2020Article
- Comparative genomics of the major parasitic worms.Nature genetics · 2019Article
- Nicotine-sensitive acetylcholine receptors are relevant pharmacological targets for the control of multidrug resistant parasitic nematodes.International journal for parasitology. Drugs and drug resistance · 2018Article
- BRC4Env, a network of Biological Resource Centres for research in environmental and agricultural sciences.Environmental science and pollution research international · 2018Article
- Article
- Assessments of iodoindoles and abamectin as inducers of methuosis in pinewood nematode, Bursaphelenchus xylophilus.Scientific reports · 2017Article
- A BRIEF REVIEW ON THE MODE OF ACTION OF ANTINEMATODAL DRUGS.Acta veterinaria · 2017Article
- Functional genomics inProceedings of the National Academy of Sciences of the United States of America · 2017Article
- The cholinomimetic morantel as an open channel blocker of the Ascaris suum ACR-16 nAChR.Invertebrate neuroscience : IN · 2016Article
- The genome of Onchocerca volvulus, agent of river blindness.Nature microbiology · 2016Article
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 4 countries.
Funding
Abstract
Acetylcholine receptors are pentameric ligand-gated channels involved in excitatory neuro-transmission in both vertebrates and invertebrates. In nematodes, they represent major targets for cholinergic agonist or antagonist anthelmintic drugs. Despite the large diversity of acetylcholine-receptor subunit genes present in nematodes, only a few receptor subtypes have been characterized so far. Interestingly, parasitic nematodes affecting human or animal health possess two closely related members of this gene family, acr-26 and acr-27 that are essentially absent in free-living or plant parasitic species. Using the pathogenic parasitic nematode of ruminants, Haemonchus contortus, as a model, we found that Hco-ACR-26 and Hco-ACR-27 are co-expressed in body muscle cells. We demonstrated that co-expression of Hco-ACR-26 and Hco-ACR-27 in Xenopus laevis oocytes led to the functional expression of an acetylcholine-receptor highly sensitive to the anthelmintics morantel and pyrantel. Importantly we also reported that ACR-26 and ACR-27, from the distantly related parasitic nematode of horses, Parascaris equorum, also formed a functional acetylcholine-receptor highly sensitive to these two drugs. In Caenorhabditis elegans, a free-living model nematode, we demonstrated that heterologous expression of the H. contortus and P. equorum receptors drastically increased its sensitivity to morantel and pyrantel, mirroring the pharmacological properties observed in Xenopus oocytes. Our results are the first to describe significant molecular determinants of a novel class of nematode body wall muscle AChR.
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