Evidence map›Paper›PMID 26624855›Full record

SynthesisBritish journal of clinical pharmacology2016

Statin therapy and plasma free fatty acids: a systematic review and meta-analysis of controlled clinical trials.

Amirhossein Sahebkar, Luis E Simental-Mendía, Claudio Pedone, Gianna Ferretti, Petr Nachtigal, Simona Bo, Giuseppe Derosa, Pamela Maffioli, Gerald F Watts

Open access · bronzeAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in British journal of clinical pharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 4 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 4 syntheses or guidelines pooled it, 45 citations in OpenAlex.

  1. Pooled it
  2. Effect of ezetimibe on plasma adipokines: a systematic review and meta-analysis.British journal of clinical pharmacology · 2017 · on this map
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Heterogeneous Causes of Acute Respiratory Distress Syndrome Correlate With Distinct Peripheral Polyunsaturated Fatty Acid Metabolites.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
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  14. Reproductive Functions of the Mitochondrial Progesterone Receptor (PR-M).Reproductive sciences (Thousand Oaks, Calif.) · 2023
    Review
  15. Review
  16. Strategies for Therapeutic Amelioration of Aberrant Plasma ZnInternational journal of molecular sciences · 2022
    Review
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 8 institutions in 6 countries.

Amirhossein SahebkarBiotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, 9177948564, Iran.
Luis E Simental-MendíaBiomedical Research Unit, Mexican Social Security Institute, Durango.
Claudio PedoneArea di Geriatria, Università Campus Biomedico di Roma, Via Alvaro del Portillo 21, 00128, Roma.
Gianna FerrettiDipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche (DISCO), Università Politecnica Delle Marche, Italy.
Petr NachtigalFaculty of Pharmacy in Hradec Kralove, Department of Biological and Medical Sciences, Charles University in Prague, Hradec Kralove, Czech Republic.
Simona BoDepartment of Medical Sciences, University of Turin, Turin.
Giuseppe DerosaCenter for the Study of Endocrine-Metabolic Pathophysiology and Clinical Research, University of Pavia, Pavia.
Pamela MaffioliDepartment of Internal Medicine and Therapeutics, University of Pavia and Fondazione IRCCS Policlinico S. Matteo, Pavia, Pavia, Italy.
Gerald F WattsLipid Disorders Clinic, Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia.
University of Pavia · ITBiotechnology Research Center · IRCharles University · CZMarche Polytechnic University · ITMexican Social Security Institute · MXRoyal Perth Hospital · AUUniversità Campus Bio-Medico · ITUniversity of Turin · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThe aim of this meta-analysis was to evaluate the effect of statin therapy on plasma FFA concentrations in a systematic review and meta-analysis of controlled clinical trials.

methodsPubMed-Medline, SCOPUS, Web of Science and Google Scholar databases were searched (from inception to February 16 2015) to identify controlled trials evaluating the impact of statins on plasma FFA concentrations. A systematic assessment of bias in the included studies was performed using the Cochrane criteria. A random effects model and generic inverse variance method were used for quantitative data synthesis. Sensitivity analysis was conducted using the leave-one-out method. Random effects meta-regression was performed using unrestricted maximum likelihood method to evaluate the impact of potential moderators.

resultsMeta-analysis of data from 14 treatment arms indicated a significant reduction in plasma FFA concentrations following treatment with statins (weighted mean difference (WMD) -19.42%, 95% CI -23.19, --15.64, P < 0.001). Subgroup analysis confirmed the significance of the effect with both atorvastatin (WMD -20.56%, 95% CI -24.51, -16.61, P < 0.01) and simvastatin (WMD -18.05%, 95% CI -28.12, -7.99, P < 0.001). Changes in plasma FFA concentrations were independent of treatment duration (slope -0.10, 95% CI -0.30, 0.11, P = 0.354) and magnitude of reduction in plasma low density lipoprotein cholesterol concentrations (slope 0.55, 95% CI -0.17, 1.27, P = 0.133) by statins.

conclusionsThe results of the present study suggest that statin therapy may lower plasma FFA concentrations. The cardiovascular and metabolic significance of this finding requires further investigation.

Indexed as

Cardiovascular DiseasesCholesterol, LDLFatty Acids, NonesterifiedHumansHydroxymethylglutaryl-CoA Reductase InhibitorsRandomized Controlled Trials as TopicCholesterol, LDLFatty Acids, NonesterifiedHydroxymethylglutaryl-CoA Reductase Inhibitorscholesteroldyslipidaemiafatty acidmeta-analysisstatins

Identifiers

PMID26624855
PMCPMC4834596
OpenAlexW2186581015

What OpenQuestion holds

Texttitle and abstract
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.