ArticlePloS one2015
Banking or Bankrupting: Strategies for Sustaining the Economic Future of Public Cord Blood Banks.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05836974 (Performance Evaluation of the ex Utero Cord Blood Collection Technique), which is not on this map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Performance Evaluation of the ex Utero Cord Blood Collection Technique: Procedure, Quality and Results
Who cites it
14 citing papers in PubMed.
- Quality and stability studies of red blood cell concentrates from umbilical cord blood compared to their adult counterparts.Blood transfusion = Trasfusione del sangue · 2025Article
- New player in CAR-T manufacture field: comparison of umbilical cord to peripheral blood strategies.Frontiers in immunology · 2025Review
- Multi-component cord blood banking: a proof-of-concept international exercise.Blood transfusion = Trasfusione del sangue · 2023Article
- A Portrait of Cord Blood Units Distributed for Transplantation from Canadian Blood Services' Cord Blood Bank: First Analysis.Current oncology (Toronto, Ont.) · 2022Article
- Functional copy number variation of CsSHINE1 is associated with fruit skin netting intensity in cucumber, Cucumis sativus.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Article
- Umbilical cord blood transplants facilitated by the French cord blood banks network. On behalf of the Agency of Biomedicine, Eurocord and the French society of bone marrow transplant and cell therapy (SFGM-TC).Bone marrow transplantation · 2021Article
- Article
- Recycling Apparent Waste Into Biologicals: The Case of Umbilical Cord Blood in Italy and Spain.Frontiers in cell and developmental biology · 2021Article
- Evaluation of Cord Blood Total Nucleated and CD34Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2020Article
- The Future State of Newborn Stem Cell Banking.Journal of clinical medicine · 2019Article
- Factors Influencing the Umbilical Cord Blood Stem Cell Industry: An Evolving Treatment Landscape.Stem cells translational medicine · 2018Review
- A cost analysis of public cord blood banks belonging to the Italian Cord Blood Network.Blood transfusion = Trasfusione del sangue · 2018Article
- Article
- Nucleated red blood cell: a feasible quality parameter of cord blood units.Hematology, transfusion and cell therapyArticle
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
backgroundCord blood is an important source of stem cells. However, nearly 90% of public cord blood banks have declared that they are struggling to maintain their financial sustainability and avoid bankruptcy. The objective of this study is to evaluate how characteristics of cord blood units influence their utilization, then use this information to model the economic viability and therapeutic value of different banking strategies.
methodsRetrospective analysis of cord blood data registered between January 1st, 2009 and December 31st, 2011 in Bone Marrow Donor Worldwide. Data were collected from four public banks in France, Germany and the USA. Samples were eligible for inclusion in the analysis if data on cord blood and maternal HLA typing and biological characteristics after processing were available (total nucleated and CD34+ cell counts). 9,396 banked cord blood units were analyzed, of which 5,815 were Caucasian in origin. A multivariate logistic regression model assessed the influence of three parameters on the CBU utilization rate: ethnic background, total nucleated and CD34+ cell counts. From this model, we elaborated a Utilization Score reflecting the probability of transplantation for each cord blood unit. We stratified three Utilization Score thresholds representing four different banking strategies, from the least selective (scenario A) to the most selective (scenario D). We measured the cost-effectiveness ratio for each strategy by comparing performance in terms of number of transplanted cord blood units and level of financial deficit.
resultsWhen comparing inputs and outputs over three years, Scenario A represented the most extreme case as it delivered the highest therapeutic value for patients (284 CBUs transplanted) along with the highest financial deficit (USD 5.89 million). We found that scenario C resulted in 219 CBUs transplanted with a limited deficit (USD 0.98 million) that charities and public health could realistically finance over the long term. We also found that using a pre-freezing level of 18 x 10(8) TNC would be the most cost-effective strategy for a public bank.
conclusionOur study shows that a swift transition from strategy A to C can play a vital role in preventing public cord blood banks worldwide from collapsing.
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