Evidence map›Paper›PMID 26624019›Full record

ArticlePloS one2015

orthoFind Facilitates the Discovery of Homologous and Orthologous Proteins.

Pablo Mier, Miguel A Andrade-Navarro, Antonio J Pérez-Pulido

Abstract read
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Pablo MierCentro Andaluz de Biología del Desarrollo (CABD), CSIC-UPO-JA. Facultad de Ciencias Experimentales (Área de Genética), Universidad Pablo de Olavide, ES-41013, Sevilla, Spain.
Miguel A Andrade-NavarroFaculty of Biology, Johannes Gutenberg University Mainz, Mainz, Germany.
Antonio J Pérez-PulidoCentro Andaluz de Biología del Desarrollo (CABD), CSIC-UPO-JA. Facultad de Ciencias Experimentales (Área de Genética), Universidad Pablo de Olavide, ES-41013, Sevilla, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Finding homologous and orthologous protein sequences is often the first step in evolutionary studies, annotation projects, and experiments of functional complementation. Despite all currently available computational tools, there is a requirement for easy-to-use tools that provide functional information. Here, a new web application called orthoFind is presented, which allows a quick search for homologous and orthologous proteins given one or more query sequences, allowing a recurrent and exhaustive search against reference proteomes, and being able to include user databases. It addresses the protein multidomain problem, searching for homologs with the same domain architecture, and gives a simple functional analysis of the results to help in the annotation process. orthoFind is easy to use and has been proven to provide accurate results with different datasets. Availability: http://www.bioinfocabd.upo.es/orthofind/.

Indexed as

Sequence Homology, Amino AcidAmino Acid SequenceAnimalsDatabases, GeneticHumansInternetProteinsSequence AlignmentSoftwareProteins

Identifiers

PMID26624019
PMCPMC4666658

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.