ArticleeLife2015
Mechanical stress contributes to the expression of the STM homeobox gene in Arabidopsis shoot meristems.
Article in eLife, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.
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Who cites it
74 citing papers in PubMed, 160 citations in OpenAlex.
- The evolutionary origins of streptophyte multicellularity.The New phytologist · 2026Review
- Characterization of BrSTM16 from Brassica rapa and functional analysis of its role in regulating cold tolerance.BMC plant biology · 2026Article
- Mapping the zygote-to-adult developmental cell phylogeny in Arabidopsis thaliana reveals a three-cell rule of branching.Nature plants · 2026Article
- Big data approaches to understanding gene regulatory networks in the shoot apical meristem andFrontiers in plant science · 2026Review
- CSLD5-mediated cell wall remodelling regulates tissue mechanics and shoot meristem growth.Nature communications · 2025Article
- miR394 and LCR cooperate with TPL to regulate AM initiation.Nature communications · 2024Article
- What Is a Plant Cell Type in the Age of Single-Cell Biology? It's Complicated.Annual review of cell and developmental biology · 2024Review
- Sugar signaling modulates SHOOT MERISTEMLESS expression and meristem function inProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Water fluxes pattern growth and identity in shoot meristems.Nature communications · 2024Article
- Spatiotemporally distinct responses to mechanical forces shape the developing seed of Arabidopsis.The EMBO journal · 2024Article
- When Size Matters: New Insights on How Seed Size Can Contribute to the Early Stages of Plant Development.Plants (Basel, Switzerland) · 2024Review
- A CUC1/auxin genetic module links cell polarity to patterned tissue growth and leaf shape diversity in crucifer plants.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- HISTONE DEACETYLASE19 Controls Ovule Number Determination and Transmitting Tract Differentiation.Plant physiology · 2024Article
- Hormone-regulated expansins: Expression, localization, and cell wall biomechanics in Arabidopsis root growth.Plant physiology · 2023Article
- Review
- Characterization of the Molecular Events Underlying the Establishment of Axillary Meristem Region in Pepper.International journal of molecular sciences · 2023Article
- Increased gene expression variability hinders the formation of regional mechanical conflicts leading to reduced organ shape robustness.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- The Secrets of Meristems Initiation: Axillary Meristem Initiation and Floral Meristem Initiation.Plants (Basel, Switzerland) · 2023Review
- Salinity-Triggered Responses in Plant Apical Meristems for Developmental Plasticity.International journal of molecular sciences · 2023Review
- Comparisons between Plant and Animal Stem Cells Regarding Regeneration Potential and Application.International journal of molecular sciences · 2023Review
14 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
Abstract
The role of mechanical signals in cell identity determination remains poorly explored in tissues. Furthermore, because mechanical stress is widespread, mechanical signals are difficult to uncouple from biochemical-based transduction pathways. Here we focus on the homeobox gene SHOOT MERISTEMLESS (STM), a master regulator and marker of meristematic identity in Arabidopsis. We found that STM expression is quantitatively correlated to curvature in the saddle-shaped boundary domain of the shoot apical meristem. As tissue folding reflects the presence of mechanical stress, we test and demonstrate that STM expression is induced after micromechanical perturbations. We also show that STM expression in the boundary domain is required for organ separation. While STM expression correlates with auxin depletion in this domain, auxin distribution and STM expression can also be uncoupled. STM expression and boundary identity are thus strengthened through a synergy between auxin depletion and an auxin-independent mechanotransduction pathway at the shoot apical meristem.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.